Effect of bite-raised condition on the hippocampal cholinergic system of aged SAMP8 mice

Katayama, Tasuku; Mori, Daisuke; Miyake, Hidekazu; Fujiwara, Shuu; Ono, Yumie; Takahashi, Toru; Onozuka, Minoru; Kubo, Kin‐ya

doi:10.1016/j.neulet.2012.05.035

Cited by 20 publications

(16 citation statements)

References 35 publications

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“…Targeting the cholinergic system with cholinesterase inhibitors, which leads to cognitive improvement in patients afflicted with age-related dementia, could possibly exert its therapeutic action through stimulation of hippocampal neurogenesis 51, 52. In the molarless or bite-raised aged mice, hippocampal acetylcholine release, acetyltransferase and choline acetyltransferase activity were significantly decreased 13, 53. The number of choline acetyltransferase-immunopositive neurons in the medial septal nucleus was also reduced.…”

Section: Hippocampal Functional Morphological Changes Caused the Mastmentioning

confidence: 99%

Chewing Maintains Hippocampus-Dependent Cognitive Function

Chen¹,

Iinuma²,

Onozuka³

et al. 2015

Int. J. Med. Sci.

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105

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Mastication (chewing) is important not only for food intake, but also for preserving and promoting the general health. Recent studies have showed that mastication helps to maintain cognitive functions in the hippocampus, a central nervous system region vital for spatial memory and learning. The purpose of this paper is to review the recent progress of the association between mastication and the hippocampus-dependent cognitive function. There are multiple neural circuits connecting the masticatory organs and the hippocampus. Both animal and human studies indicated that cognitive functioning is influenced by mastication. Masticatory dysfunction is associated with the hippocampal morphological impairments and the hippocampus-dependent spatial memory deficits, especially in elderly. Mastication is an effective behavior for maintaining the hippocampus-dependent cognitive performance, which deteriorates with aging. Therefore, chewing may represent a useful approach in preserving and promoting the hippocampus-dependent cognitive function in older people. We also discussed several possible mechanisms involved in the interaction between mastication and the hippocampal neurogenesis and the future directions for this unique fascinating research.

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Section: Hippocampal Functional Morphological Changes Caused the Mastmentioning

confidence: 99%

Chewing Maintains Hippocampus-Dependent Cognitive Function

Chen¹,

Iinuma²,

Onozuka³

et al. 2015

Int. J. Med. Sci.

Self Cite

100

105

View full text Add to dashboard Cite

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“…Exposure to chronic stress affects the survival, proliferation and differentiation rate of young cells. Stress is associated with elevated glucocorticoid levels leading to apoptosis [17]. The presence of glucocorticoids in elevated concentrations decrease the antioxidant defense capacity in neurons.…”

Section: Resultsmentioning

confidence: 99%

Consequences of Dental Occlusion Enhancement by Means of Metal Crowns on the Animal Model

Ispas¹,

Craciun²,

Lascu³

et al. 2019

Rev. Chim.

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The purpose of this study was to determine whether there is a correlation between induced occlusal trauma and the occurrence of oxidative stress in the hippocampus. Twenty Wistar rats were randomized into three experimental groups and one control group. Animals in the experimental group were cemented modified crowns on molars to induce occlusal trauma in 7, 14 and 30 days. To evaluate the oxidative stress, blood was drawn from the hippocampus at 7, 14 and 30 day intervals. Oxidative stress was evaluated using the following specific tests: determination of plasma malondialdehyde and serum glutathione values. The results of the study demonstrate that malocclusion experienced by raising the vertical dimension in rats resulted in significant reductions in antioxidants and increase level of free radicals.

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“…Previous studies have shown that occlusal disharmony induces chronic stress, which results in learning deficits in association with the morphologic changes in the hippocampus, for example, neuronal degeneration and increased hypertrophied GFAP–positive cells . Moreover, the aged bite‐raised mice showed decreased acetylcholine release in the hippocampus and a reduced number of choline acetyltransferase‐immunopositive neurons in the medial septal nucleus compared to age‐matched control mice . These findings suggested that the bite‐raised condition in aged SAMP8 mice enhanced the age‐related decline in the septohippocampal cholinergic system, leading to impaired learning.…”

Section: Resultsmentioning

confidence: 99%

The biological effects of occlusal trauma on the stomatognathic system – a focus on animal studies

Liu

Jiang

Wang

2012

J of Oral Rehabilitation

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The aim of this review of the literature was to assess the biological effects of occlusal trauma on the stomatognathic system focusing on animal studies. However, there are no conclusive explanations on the association between occlusal trauma and disease of the stomatognathic system. A literature survey was performed using the Medline database, covering the period from 1967 to 2012. Over 300 abstracts were reviewed, and 70 manuscripts were selected. Additional references from citations within the articles were obtained, and current textbooks were also used. This review does not include the effects of occlusal trauma on dental implants or dental prostheses/appliances. A total of 70 full articles were included for the final analysis. The selected 70 articles were classified into the following five categories, including the effects of occlusal trauma on the pulp tissues, periodontal tissues, masticatory muscle, temporomandibular joint (TMJ) and central nervous system (CNS). It was demonstrated that occlusal trauma caused a variety of harmful biological effects on stomatognathic system. Additionally, occlusal trauma could lead to some pain substance changes in the pulp, periodontal tissues, masticatory muscle, TMJ and CNS, which was possibly related to the peripheral and the central neuronal sensitisation. However, these findings demonstrate that there are remaining disagreements by various authors. More randomised trials are needed to validate these effects.

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Effect of bite-raised condition on the hippocampal cholinergic system of aged SAMP8 mice

Cited by 20 publications

References 35 publications

Chewing Maintains Hippocampus-Dependent Cognitive Function

Chewing Maintains Hippocampus-Dependent Cognitive Function

Consequences of Dental Occlusion Enhancement by Means of Metal Crowns on the Animal Model

The biological effects of occlusal trauma on the stomatognathic system – a focus on animal studies

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