The biological effects of occlusal trauma on the stomatognathic system – a focus on animal studies

Liu, H.; Jiang, Hua; Wang, Y.

doi:10.1111/joor.12017

Cited by 12 publications

(11 citation statements)

References 55 publications

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“…Previous studies of occlusal trauma have mainly included clinical observations, data analysis, animal models, and finite element analysis of periodontal tissues. Several studies on the translation of mechanical stimuli into biochemical signals and the underlying mechanism have focused on promoting osteoclast formation.…”

Section: Introductionmentioning

confidence: 99%

Occlusal trauma inhibits osteoblast differentiation and bone formation through IKK‐NF‐κB signaling

Lü

Yue

et al. 2019

Journal of Periodontology

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Background:Occlusal trauma is an important factor promoting bone loss caused by periodontal diseases. Although there are reports of traumatic force promoting bone resorption in periodontal diseases, no studies examining the inhibition of bone formation by traumatic force and the underlying mechanism have been reported. The aim of this study was to investigate the mechanism whereby traumatic force inhibits bone formation.Methods: MC3T3-E1 cells were induced to undergo osteogenic differentiation and subjected to cyclic uniaxial compressive stress with or without stimulation with Pg. LPS. The expression of osteoblast markers and the activation of IKK-NF-B signaling were evaluated in vitro. Then, MC3T3-E1 cells were induced to undergo osteogenic differentiation and subjected to cyclic uniaxial compressive stress with or without IKK-2 Inhibitor VI. The expression of osteoblast markers was determined. Then, the classic Wnt signaling pathway ( -catenin, Gsk3 , p-Gsk3 , and Dkk1) was further evaluated in vitro. Finally, occlusal trauma was induced in Wistar rats with or without the injection of IKK-2 Inhibitor VI, to evaluate changes in bone mass and IKK-NF-B and Wnt/ -catenin signaling in vivo. Results:After stimulation with Pg. LPS and traumatic force, IKK-NF-B signaling was significantly activated in vitro. The expression of osteoblast markers and the activity of alkaline phosphatase in MC3T3-E1 cells declined after traumatic force loading and were rescued when IKK-NF-B signaling was blocked. Wnt/ -catenin signaling was accordingly inhibited upon force loading, but this inhibition was reversed when IKK-NF-B was antagonized in vitro. X-ray and Micro-CT analysis of the mandibles of the rats as well as HE and TRAP staining showed that bone loss induced by occlusal trauma declined after IKK-NF-B was inhibited. The expression of p65 and I B was increased when occlusal trauma was induced in Wistar rats, whereas -catenin, OCN, and Runx2 levels were decreased. After J Periodontol. 2020;91:683-692.

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Section: Introductionmentioning

confidence: 99%

Occlusal trauma inhibits osteoblast differentiation and bone formation through IKK‐NF‐κB signaling

Lü

Yue

et al. 2019

Journal of Periodontology

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“…A similar conclusion was reached in a review article on the biologic effects of occlusal trauma, based on evidence primarily from animal studies. 30 …”

Section: Reinhardt and Killeenmentioning

confidence: 97%

Do Mobility and Occlusal Trauma Impact Periodontal Longevity?

Reinhardt

Killeen

2015

Dental Clinics of North America

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“…Ideal functional occlusion is characterized by an appropriate intercuspal tooth, to preserve all physiological components of the stomatognathic system, namely the dental occlusion, the temporomandibular joint, the tooth attachment and the entire neuromuscular mechanism involved in the process of biomechanics of occlusion 3 . Harmonious occlusion occurs when there is a mandibular relationship in centric and eccentric relation in which there are no interceptive or deflector contacts of the occlusal surfaces 4 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of bone loss due to primary occlusal trauma in two experimental models of occlusal overload

Lopes

Téo

Corrêa

et al. 2016

Rev. odontol. UNESP

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ResumoIntrodução: Trauma oclusal primário (TO) é a injúria causada no periodonto de inserção de dentes com periodonto de altura normal devido a forças oclusais que excedem sua capacidade adaptativa. Objetivo: Avaliar histometricamente a reabsorção óssea alveolar na região da furca do 1º molar inferior em ratos submetidos experimentalmente a 2 modelos de sobrecarga oclusal. Material e método: 45 animais aleatoriamente divididos em 3 Grupos: Interferência Oclusal (GI, n = 15) -fixação de um segmento de fio ortodôntico na face oclusal do 1º molar inferior; Sobrecarga Oclusal (GS, n = 15) -desgaste das cúspides dos molares inferiores contralaterais e dos 2º e 3º molares do lado do 1º molar que teve suas dimensões mantidas; Grupo Controle Negativo (CN, n = 15) -avaliação das dimensões iniciais do ligamento periodontal. Cinco animais/grupo foram submetidos à eutanásia após 14, 21 e 28 dias. Resultado: A avaliação intergrupos mostrou que houve reabsorção óssea significativa em GI (p<0,001) e GS (p<0,01) quando comparados com CN. O grupo GI teve reabsorção óssea significativamente maior quando comparado ao grupo GS em 14 (p<0,01), 21 (p<0,01) e 28 dias (p<0,01). A avaliação intragrupos não mostrou influência significativa do tempo na reabsorção óssea em GI e GS, independente da técnica utilizada (p>0,05). A espessura do ligamento periodontal manteve-se estável no grupo CN (p>0,05). Conclusão: GI e GS foram eficazes na reprodução experimental do TO e GI promoveu maior reabsorção óssea alveolar quando comparado a GS, mostrando que o impacto causado pela sobrecarga oclusal no grupo GI aumentou a lesão por TO.Descritores: Reabsorção óssea; oclusão dental; ferimentos e lesões; ratos. AbstractIntroduction: Primary occlusal trauma (OT) is an injury of the periodontium with normal height as a result of occlusal forces which exceed their adaptive capacity. Objective: To evaluate, histometrically, the alveolar bone loss in the furcation region of rats experimentally submitted to 2 models of occlusal overload. Material and method: 45 animals randomly divided into 3 groups: Occlusal Interference (OI, n = 15) -fixing an orthodontic wire segment on the occlusal surface of the first lower molar; Occlusal Overload (OO, n = 15) -wearing of the cusps of the lower contralateral molars, the second and third molars next to the first molar that had its dimensions maintained; Negative Control (NC, n = 15) -evaluation of the initial dimensions of the periodontal ligament (PL). Five animals / group were sacrificed after 14, 21 and 28 days. Result: Intergroup evaluation showed significant bone loss in OI (p<0.001) and OO (p<0.01) compared to NC. OI had significantly higher bone loss compared to OO at 14 (p<0.01), 21 (p <0.01) and 28 days (p<0.01). The intragroup evaluation showed no significant influence of time on bone loss in OI and OO, regardless of the technique used (p>0.05). The thickness of the PL remained stable in NC (p>0.05). Conclusion: OI and OO were effective in the experimental reproduction of OT, and OI promoted greater alveolar b...

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The biological effects of occlusal trauma on the stomatognathic system – a focus on animal studies

Cited by 12 publications

References 55 publications

Occlusal trauma inhibits osteoblast differentiation and bone formation through IKK‐NF‐κB signaling

Occlusal trauma inhibits osteoblast differentiation and bone formation through IKK‐NF‐κB signaling

Do Mobility and Occlusal Trauma Impact Periodontal Longevity?

Evaluation of bone loss due to primary occlusal trauma in two experimental models of occlusal overload

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