Effect of biliary drainage on inducible nitric oxide synthase, CD14 and TGR5 expression in obstructive jaundice rats

Wang, Zi-Kai; Xiao, Jianguo; Huang, Xuefei; Gong, Yan; Li, Wen

doi:10.3748/wjg.v19.i15.2319

Cited by 8 publications

(8 citation statements)

References 33 publications

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“…Although there are various different rat models to choose from, researchers do not seem to accept most of them. In newly published articles, choledochoduodenostomy was still the prior internal drainage technique for many researchers [ 1 17 18 19 20 21 ]. However, choledochoduodenostomy was not suitable in some studies because of high mortality and morbidity rates and poor stability [ 4 5 9 16 22 23 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, the models of obstructive jaundice (OJ) and its reversal are frequently used in many experimental studies such as on the benefits and risks of preoperative internal and external drainage, short-term and long-term outcomes after surgery, and metabolism changes in liver and digestive tract [ 1 2 3 4 ]. An ideal model for OJ and its reversal should be technically easy, stable during the study period, and associated with low mortality and morbidity rates.…”

Section: Introductionmentioning

confidence: 99%

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A simple rat model ofin situreversible obstructive jaundicein situreversible obstructive jaundice model

Huang

Zhang

et al. 2017

Ann Surg Treat Res

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PurposeTo develop a simple and reliable rat model of in situ reversible obstructive jaundice with low morbidity and mortality rates.MethodsRats were divided into 4 groups with 8 rats each: the sham-operated (SH) group only underwent laparotomy, the control internal drainage (ID-C) group underwent choledochoduodenostomy, the new internal drainage (ID-N) group and the long-term internal drainage (ID-L) group underwent choledochocholedochostomy. Common bile duct ligation was performed in all the drainage groups 7 days before reversal procedures. All rats were sacrificed for samples 7 days after the last operation except rats of the ID-L group that survived 28 days before sacrifice. Body weight, liver function, histopathological changes, morbidity and mortality were assessed.ResultsOne rat died and 2 rats had complications with tube blockage in the ID-C group. No death or complications occurred in the ID-N and ID-L groups. The drainage tube remained patent in the long-term observation ID-L group. Body weight showed no significant difference between the ID-C and ID-N groups after 7 days drainage. Liver function was not fully recovered in the ID-C and ID-N groups after 7 days drainage, but statistical differences were only observed in the ID-C group compared with the SH and ID-L groups. Periportal inflammation and bile duct proliferation showed severer in the ID-C group than in the ID-N group.ConclusionThe present study provided an efficient, simple, and reliable rat model that is especially suitable for long-term or consecutive studies of reversible obstructive jaundice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A simple rat model ofin situreversible obstructive jaundicein situreversible obstructive jaundice model

Huang

Zhang

et al. 2017

Ann Surg Treat Res

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“…Internal drainage is more physiological than external drainage, as the enterohepatic circulation of bile is maintained. The benefits of internal drainage have been demonstrated in a series of animal experiments conducted by our team concerning internal and external drainage for the management of obstructive jaundice [40][41][42]. Our results indicated that internal drainage was superior to external drainage in restoring the damaged intestinal barrier, inhibiting bacterial translocation and reducing expression of inflammatory factors.…”

Section: Discussionmentioning

confidence: 67%

Internal drainage versus external drainage in palliation of malignant biliary obstruction: a meta-analysis and systematic review

Tian

Zhang

Li³

2020

aoms

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Introduction: Preoperative biliary drainage has been widely used to treat patients with malignant biliary obstruction. However, it is still unclear which method is more effective: internal drainage or external drainage. Thus, we carried out a meta-analysis to compare the safety and efficacy of the two drainage methods in treatment of malignant biliary obstruction in terms of preoperative and postoperative complications. Material and methods: We conducted a literature search of Medline, EMBASE, PubMed, Ovid journals and the Cochrane Library, and compared internal drainage and external drainage in malignant biliary obstruction patients. The pre-and postoperative complications, stent dysfunction rate and mortality were analyzed. Results: Ten published studies (n = 1464 patients) were included in this metaanalysis. We found that patients with malignant biliary obstruction who received external drainage showed reductions in the preoperative cholangitis rate (OR = 0.33, 95% CI: 0.24-0.44, p < 0.00001), the incidence of stent dysfunction (OR = 0.41, 95% CI: 0.30-0.57, p < 0.00001), and total morbidity (OR = 0.34, 95% CI: 0.23-0.50, p < 0.00001) compared with patients who received internal drainage. Conclusions: The current meta-analysis indicates that external drainage is better than internal drainage for malignant biliary obstruction in terms of the preoperative cholangitis rate, the incidence of stent dysfunction and total morbidity, etc. However, the findings need to be confirmed by randomized controlled trials.

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“…MOJ patients are in a severe state of immunological stress during which time inflammatory cytokines are released and immune factors are consumed. Hence cellular-based immune function is decreased (8) and the immune system is inhibited (9)(10)(11). The changes in immune functions of patients are one of the key factors leading to high rates of complications and mortality which affect prognosis (12).…”

Section: Discussionmentioning

confidence: 99%

Effects of Different Palliative Jaundice Reducing Methods on Immunologic Functions in Patients with Advanced Malignant Obstructive Jaundice

Tang

Sui

et al. 2017

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Effect of biliary drainage on inducible nitric oxide synthase, CD14 and TGR5 expression in obstructive jaundice rats

Abstract: ID could be attributed to the regulatory function of activation of KCs and release of inflammatory mediators.

Cited by 8 publications

References 33 publications

A simple rat model ofin situreversible obstructive jaundicein situreversible obstructive jaundice model

A simple rat model ofin situreversible obstructive jaundicein situreversible obstructive jaundice model

Internal drainage versus external drainage in palliation of malignant biliary obstruction: a meta-analysis and systematic review

Effects of Different Palliative Jaundice Reducing Methods on Immunologic Functions in Patients with Advanced Malignant Obstructive Jaundice

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