Effect of bicellar systems on skin properties

Barbosa-Barros, Lucyanna; Barba, Clara; Cócera, Mercedes; Coderch, L.; López‐Iglesias, Carmen; Maza, Alfons de la; López, Olga

doi:10.1016/j.ijpharm.2007.10.012

Cited by 33 publications

(54 citation statements)

References 43 publications

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“…Figure 8 plots the SAXS curve of bicelles 24 h after preparation [47]. The fact that no differences were detected between this scattering curve and that obtained 14 days after preparation (data not shown), also corroborates the stability of the system.…”

Section: Dmpc/dhpc Bicellar Systemssupporting

confidence: 52%

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Structural Versatility of Bicellar Systems and Their Possibilities as Colloidal Carriers

et al. 2011

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Bicellar systems are lipid nanostructures formed by long- and short-chained phospholipids dispersed in aqueous solution. The morphological transitions of bicellar aggregates due to temperature, composition and time variations have been revised in this work. To this end, two bicellar systems have been considered; one formed by dimyristoyl-phosphatidylcholine (DMPC) and dihexanoyl- phosphatidylcholine (DHPC) and another formed by dipalmitoyl-phosphatidylcholine (DPPC) and DHPC. The relationship between the magnetic alignment, the morphology of the aggregates and the phase transition temperature (Tm) of lipids is discussed. In general terms, the non-alignable samples present rounded objects at temperature below the Tm. Above this temperature, an increase of viscosity is followed by the formation of large elongated aggregates. Alignable samples presented discoidal objects below the Tm. The best alignment was achieved above this temperature with large areas of lamellar stacked bilayers and some multilamellar vesicles. The effect of the inclusion of ceramides with different chain lengths in the structure of bicelles is also revised in the present article. A number of physical techniques show that the bicellar structures are affected by both the concentration and the type of ceramide. Systems are able to incorporate 10% mol of ceramides that probably are organized forming domains. The addition of 20% mol of ceramides promotes destabilization of bicelles, promoting the formation of mixed systems that include large structures. Bicellar systems have demonstrated to be morphologically stable with time, able to encapsulate different actives and to induce specific effects on the skin. These facts make bicellar systems good candidates as colloidal carriers for dermal delivery. However, water dilution induces structural changes and formation of vesicular structures in the systems; stabilization strategies have been been explored in recent works and are also updated here.

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Section: Dmpc/dhpc Bicellar Systemssupporting

confidence: 52%

“…Figure 7 shows the 31 P-NMR spectra for bicelles 24 h (7A) and 14 days (7B) after preparation [47]. A doublet was observed with peaks around −0.754 and −0.927 ppm (7A) and −0.764 and −0.935 ppm (7B) respectively, in addition to the reference peak sited at 0.000 ppm.…”

Section: Dmpc/dhpc Bicellar Systemsmentioning

confidence: 99%

Structural Versatility of Bicellar Systems and Their Possibilities as Colloidal Carriers

et al. 2011

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“…Bicelles as detergents in the cell-free expression of membrane proteins offer distinct advantages [34,301,302]. The effects of applying bicellar preparations to the skin have received broad attention [303–308] and were recently reviewed [309]. Of special interest seems to be the prospect of delivering drug substances to the skin using bicelles, as demonstrated for diclofenac [310].…”

Section: New and Notablementioning

confidence: 99%

When detergent meets bilayer: Birth and coming of age of lipid bicelles

Dürr

Soong

Ramamoorthy

2013

Progress in Nuclear Magnetic Resonance Spectroscopy

114

107

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“…9–12 Bicelles are lipid-detergent mixtures that are more lipid-rich than classical mixed micelles, such that the lipid present retains a bilayered state. At the detergent-rich extreme of the bicellar regime assemblies are thought to be discoidal bilayer fragments that are edge-stabilized by an annulus of detergent.…”

Section: Introductionmentioning

confidence: 99%

Bicelles at Low Concentrations

Horn

Chen

et al. 2012

Mol. Pharmaceutics

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Bilayered detergent-lipid assemblies known as bicelles have been widely used as model membranes in structural biological studies and are being explored for wider applications, including pharmaceutical use. Most studies to date have involved the use of concentrated bicelle mixtures, such that little is known about the capacity of bicellar mixtures to be diluted without unwanted transitions to non-isotropic phases. Here, different detergent/lipid mixtures have been explored, leading to the identification of two different families of bicelles for which it is possible to lower the total amphiphile (detergent+lipid) concentration to <1% (w/v) while retaining isotropic assemblies. These include a novel family of bicelles based on mixtures of 6-cyclohexyl-1-hexylphosphocholine (Cyclofos-6) and the lipid dimyristoylphosphatidylcholine (DMPC). Bicelles formed by these mixtures can be diluted to <0.5% and also have attractive biochemical properties. However, a caveat of our results is that the diffusion coefficients measured for the lipid component of the different bicelles tested were seen to be dependent on sample history, even though all samples were optically transparent. This suggests that the phase behavior of bicelles at low lipid-to-detergent ratios may be more complex than previously appreciated.

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Effect of bicellar systems on skin properties

Cited by 33 publications

References 43 publications

Structural Versatility of Bicellar Systems and Their Possibilities as Colloidal Carriers

Structural Versatility of Bicellar Systems and Their Possibilities as Colloidal Carriers

When detergent meets bilayer: Birth and coming of age of lipid bicelles

Bicelles at Low Concentrations

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