Effect of Bay Leaf Ethanol Extract on Blood Glucose Level  in Patients with Type 2 Diabetes Mellitus

Widyawati, Tri; Pase, M. Aron; Daulay, Milahayati; Sumantri, Imam Bagus

doi:10.26911/the6thicph-fp.05.07

Cited by 4 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diabetic volunteers in this study had high BGL levels, indicating that their diabetes was uncontrolled. The FBGL was reduced to 8.85% after 14 days of administration of the capsule (61). Leaf extracts given at a dose of 5.0 mg/kg body weight/day show an anti-diabetic effect (62).…”

Section: Antidiabeticmentioning

confidence: 99%

Review of Ethnopharmacology, Morpho-Anatomy, Biological Evaluation and Chemical Composition of Syzygium polyanthum (Wight) Walp.

Abdulrahman

2021

Plant Sci. Today

View full text Add to dashboard Cite

Syzygium polyanthum (Wight) Walp, a Myrtaceae member, is widely distributed in Southeast Asian countries. The Malays and Indonesians consume the leaves regularly as Ulam (food). It has also been used in traditional medicine to treat several ailments, including gastritis, hypertension, hypercholesterolemia, diarrhea, skin diseases, diabetes and endometriosis. So far, many publications on the biological activity and chemical profile of the plant have been published. There is a need to thoroughly examine the articles and combine the major findings highlighting the potential utility of the species. Thus, the present study aimed to review the ethnopharmacology, morpho-anatomy, biological evaluation and chemical composition of S. polyanthum. In vivo, in vitro antibacterial, antimicrobial, antidiabetic, antioxidants, essential oil and chemical composition of S. polyanthum were searched in Google Scholar, Scopus, Web of Science and PubMed. The investigations revealed that S. polyanthum is a medicinal plant with proven antioxidant, antibacterial, antifungal, antidiabetic and anti inflammatory activities. The plant had a substantial impact on human health. Chemical ingredients extracted and characterised are monoterpene, sesquiterpene, oxygenated monoterpenes, oxygenated sesquiterpenes, phenolic and flavonoid compounds. The review found that the in vitro and in vivo biological evaluation of S. polyanthum was well documented. In order to have conclusive results on the plant leaves efficacy, a well-designed clinical trial is required. Efforts should also be taken for long-term conservation and management.

show abstract

Section: Antidiabeticmentioning

confidence: 99%

Review of Ethnopharmacology, Morpho-Anatomy, Biological Evaluation and Chemical Composition of Syzygium polyanthum (Wight) Walp.

Abdulrahman

2021

Plant Sci. Today

View full text Add to dashboard Cite

show abstract

“…Clinical study in human to verify the anti-diabetic activity of S. polyanthum leaves is limited. However, a study with a small number of participants (< 10) found that administering a capsulated ethanolic extract of S. polyanthum for 14 days reduced fasting blood glucose levels in diabetic patients (Widyawati et al 2019). In a different trial, Widyawati et al (2019) found that 350 mg of the ethanol extract was safe to be consumed by healthy human volunteers during 28 days of treatment.…”

Section: Antidiabetic Activity and Mechanism Of Actionsmentioning

confidence: 99%

“…The healing properties of these plants are probably due to their bioactive compounds such as phenolics, glycosides, alkaloids, terpenoids, flavonoids, and carotenoids (Kayarohanam & Kavimani 2015;Zohary & Hopf 2000). Scientific studies have proven the efficacy of these herbs in preventing and treating diabetes (Rahim et al 2018;Widyawati et al 2019;Yin et al 2014). Preclinical trials for E. palmifolia, M. charantia, and S. polyanthum also provided abundance of data for their anti-diabetic effects (Febrinda et al 2014;Lelono & Tachibana 2013;Sandikapura et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Anti-diabetic properties of traditional herbal concoction containing Eleutherine palmifolia (L.) Merr., Momordica charantia L., and Syzygium polyanthum (Wight.): a bibliometric analysis

Hairani,

Abdul Majid,

Zakaria

et al. 2023

Food Prod Process and Nutr

View full text Add to dashboard Cite

Eleutherine palmifolia, Momordica charantia, and Syzygium polyanthum are herbal plants, traditionally used as natural remedies for diabetes. There have been numerous articles published on the anti-diabetic efficacy of these plants; yet, no bibliometric study on the subject is available. In this study, the published papers on the utilization of E. palmifolia, M. charantia, and S. polyanthum as anti-diabetic agents were examined using bibliometric approach, focusing on countries, organizations, authors, and keywords. The phytochemicals, pharmacological properties, and mechanism of action of each herbal plant associated with diabetes were also discussed in detail. The data were searched through the SCOPUS database and bibliometric analysis was performed using VOSviewer software. The World Flora Online (WFO) was used to confirm the identity of the plant species. A total of 1008 articles were retrieved with M. charantia (977 articles) showing the highest number of publishing articles compared to E. palmifolia (9 articles), and S. polyanthum (22 articles). Upon further review of these plants, the findings showed that each plant has active ingredients that can prevent as well as control the complications of diabetes. Eleutherol, eleuthenone, eleutherinoside A, kuguacin, momordicin, vicine, squalene, myricitrin and epigallocatechin gallate (EGCG) were among the phytochemicals responsible for the effect. The possible underlying mechanisms of action were attributed to lowering blood glucose, increasing insulin production, inhibiting intestinal glucose absorption, and enhancing glucose uptake by the muscles. Based on the review, it is evidenced that the individual plants demonstrated a promising anti-diabetic activity, thus, it is recommended to conduct further studies using a polyherbal mixture, combining these three extracts and analyzing using in vitro and in vivo models. Graphical Abstract

show abstract

“…Hyperglycemia, an elevated blood glucose concentration, is a hallmark of diabetes mellitus, a chronic metabolic disorder that develops when either the pancreas gland does not secrete enough insulin or the body does not properly use the insulin it does secrete. [1] Type 1 diabetes mellitus, which requires insulin, and type 2 diabetes mellitus, which does not, are the two main forms of the illness [2]. High glucose in both types of disease is attributed to a relative or absolute decrease in the secretion of the hormone insulin or the action of this.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Metformin on some Physiological Traits in Rats with Alloxan-Induced Diabetes

Rashid,

Muhammad,

Hussein

2024

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

The study was conducted in the laboratories of the University of Mosul, College of Veterinary Medicine, and the biological experiment was conducted in the animal house belonging to the College of Veterinary Medicine for the period from 3/1/2023 to 10/2/2023. The study included the use of the drug metformin to determine its effect on male rats with Alloxan-induced diabetes. The study included We used (24) adult male white rats, whose ages ranged from (13 to 14 weeks), and whose weights were recorded between (270 to 280 grams), at a rate of eight rats for each group, which included three groups, which were divided as follows: A healthy control group (T1), one with Alloxan-induced diabetes (T2) that received no treatment whatsoever, and a third with metformin, a chemotherapeutic drug, administered orally at a dosage of 200 mg/kg of body weight, were the three groups. The percentages of glucose, creatine, urea, glutathione (GSH), and malondialdehyde (MDA) were measured in blood tests. The levels of glucose, creatine, urea, and malondialdehyde (MDA) decreased significantly (P<0.05) in the metformin-dosed treatment group as compared to the control group. The results also shown that the percentage of glutathione (GSH) increased significantly in the same treatment (T3) compared to the control group with Alloxan-induced diabetes, at the level (P<0.05).

show abstract

Effect of Bay Leaf Ethanol Extract on Blood Glucose Level in Patients with Type 2 Diabetes Mellitus

Cited by 4 publications

References 0 publications

Review of Ethnopharmacology, Morpho-Anatomy, Biological Evaluation and Chemical Composition of Syzygium polyanthum (Wight) Walp.

Review of Ethnopharmacology, Morpho-Anatomy, Biological Evaluation and Chemical Composition of Syzygium polyanthum (Wight) Walp.

Anti-diabetic properties of traditional herbal concoction containing Eleutherine palmifolia (L.) Merr., Momordica charantia L., and Syzygium polyanthum (Wight.): a bibliometric analysis

The Effect of Metformin on some Physiological Traits in Rats with Alloxan-Induced Diabetes

Contact Info

Product

Resources

About