Effect of bare and polymeric-modified magnetic nanoparticles on the drug ion transfer across liquid/liquid interfaces

Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models

“…The DSPA isotherm using LiCl 10 mM as the electrolyte in the subphase shown in Figure 2 (black line) displays the well-known profile with a phase transition from the gaseous to the liquid condensed phase, consistent with values previously reported [ 22 ].…”

“…Additionally, for these figures, the area is given in terms of area per lipid molecule. The complete characterization of these MNPs was previously reported, where the size of both MNP types was shown to be around 12 nm [ 21 , 22 ].…”

“…This increase in the MIP value leads us to conclude that the use of MNPs can improve the insertion of the drug into DSPA preformed monolayers, reaching values even higher than 30 mN m −1 , the expected value of the surface pressure in living cells. In our previous work, we reported that HTFPZ + can interact strongly with polysaccharides-coated MNPs through hydrophobic interactions [ 22 ]. Due to this, it is expected that in the mixtures, the MNPs are interacting with HTFPZ + , improving the insertion of the drug drive by hydrophobic interactions between MNPs and HTFPZ + .…”

“…Additionally, we previously reported that DCFN − can interact strongly with MNPs driven by electrostatic interactions. In this same work, we also use DFT calculations to calculate the binding energy of a DCFN − anion with ammonium cations present in the polymers structures that are covering the MNPs, concluding that the amines group in DEAE-D interacts stronger than CHI [ 22 ]. All of this indicates that DCFN − is strongly interacting with Fe 3 O 4 @DEAE-D and can improve the drug adsorption into DSPA preformed monolayers.…”

“…Among the different MNPs, magnetite Fe 3 O 4 is the most widely proposed for use in biomedicine, as it appears to be the most biocompatible. MNPs are coated with organic materials to increase biocompatibility, prevent aggregation and also to be dispersible in aqueous media [ 20 , 21 , 22 ]. Carbohydrates are good candidates for coating MNPs, since they have been proposed in several articles [ 1 ].…”