Effect of Baluran Gum Arabic on Blood Glucose Level in Diabetic Rat (Rattus Novergicus )

Wiyono, Hidayat Teguh; Utami, Eva Tyas; Wardhani, Dinna Wahyu Putri

doi:10.19184/bst.v9i2.22533

Cited by 3 publications

(6 citation statements)

References 12 publications

(14 reference statements)

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“…Thus far, there have been no studies that have examined the effect of the administration of neem gum on the reduction in blood glucose levels. A study conducted by Wiyono et al (2021), discovered that administering Baluran arabic gum at a dose of 15% in STZinduced Wistar rats at 40 mg/kgBW could reduce fasting blood glucose levels. In the 28-day study, serial fasting blood glucose was examined every 7 days, and it was discovered that blood glucose levels in the group administered gum arabic solution at a dose of 15% decreased significantly on days 14 to 28 compared to the group that was not given gum arabic solution.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, FBG measurements were carried out before the rats were induced by STZ, three days after STZ induction (pretest), and on the last day of treatment (posttest). If the FBG level measured after STZ induction reached ≥126 mg/dL, then proceed to the administration of neem gum solution (Wiyono et al, 2021;Dewi et al, 2022). In addition, rat blood was collected aseptically with a needle (a blood lancet) by piercing the tip of the rat's tail.…”

Section: Measurement Of Fasting Blood Glucose (Fbg)mentioning

confidence: 99%

“…These polysaccharides are speculated to be responsible for the antihyperglycemic activity because they are non-digestible polysaccharides. Furthermore, Wiyono et al (2021) discovered that administration of arabic gum, which has a similar structure and composition to neem gum, orally for 28 days at a dose of 15% resulted in a reduction of blood glucose levels in wistar rats induced with diabetes. In addition, there are the antioxidants in neem gum, which can neutralize free radicals and thereby reduce oxidative stress caused by hyperglycemia.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Neem Gum on the Reduction in Rat Blood Glucose Levels Induced by Streptozotocin

Fardhani,

Firdaus,

Febianti

et al. 2023

bulvet

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Pharmacological therapy for diabetes, which is primarily made up of chemicals, still causes a lot of side effects. The numerous side effects of pharmacological therapy for diabetes have generated innovations in alternative diabetes therapies using ingredients derived from nature. One of the natural ingredients with an anti-hyperglycemia effect is neem gum (NG), or the sap of the neem plant (Azadirachta indica). The aim of this study was to determine the effect of NG on the reduction of blood glucose levels. Moreover, this study had six groups, including a normal control group and groups with doses of 0, 3.75, 7.5, 15, and 30 grams/kgBW. The results showed that NG reduced blood glucose levels in diabetic rats. The paired t-test showed a significant reduction in blood glucose in all groups administered NG except for the dose 3.75 group (P<0.05). The minimum and maximum effective doses of NG were calculated using the quadratic regression test with the equation y = 1.059x2–46.576x+408. With a target blood glucose level of between 80 and 126 mg/dL, the minimum and maximum effective doses of NG were obtained in the range of 12–15 mg/dL. This study concluded that administering NG to diabetic rats can reduce blood glucose levels. Phytochemical studies and research are needed with serial examinations using the effective dose range of neem gum.

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Section: Discussionmentioning

confidence: 99%

Section: Measurement Of Fasting Blood Glucose (Fbg)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of Neem Gum on the Reduction in Rat Blood Glucose Levels Induced by Streptozotocin

Fardhani,

Firdaus,

Febianti

et al. 2023

bulvet

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“…Kadar GDP tikus model DM lebih tinggi dibandingkan tikus normal. Penelitian ini sejalan dengan penelitian lainnya, yaitu kadar GDP tikus DM yang tidak mendapat perlakuan lebih tinggi dibanding tikus kontrol normal (Wiyono et al, 2021). Induksi NA dan STZ dapat menyebabkan kerusakan sel β pankreas secara parsial sehingga mengganggu sekresi insulin.…”

Section: Kadar Glukosa Darah Puasaunclassified

Potensi Antidiabetik Tepung Terung Ungu (Solanum Melongena L.) pada Tikus Hiperglikemia

Fajriana

2022

JKM

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Diabetes Mellitus (DM) is a group of metabolic diseases characterized and identified with hyperglycemia due to impaired insulin secretion, insulin action, or both, and the presence of impaired metabolism of carbohydrates, fats, and proteins. IDF data shows the prevalence is increasing from year to year, namely 9.3% (2020) and 10.5% (2021). Treatment of DM was needed a combination of pharmacological and non-pharmacological treatment by utilizing local foods in the diet. Purple eggplant (Solanum melongena L.) is one of the potential plants in Indonesia that is very rich in antioxidants and believed to decrease fasting blood glucose (FBG) levels. The study aimed to determine the effect of purple eggplant flour (TTU) on the weight and fasting blood glucose levels of hyperglycemia rats. This true experimental study design used a pre-post test with a control group design. Thirty-six male Sprague Dawley rats were divided randomly into five groups: KN group (7 rats), KD (8 rats), P1 (7 rats), P2 (7 rats), and P3 (7 rats). The rats used were 10-12 weeks, weighing 207.25±26.76 grams. The hyperglycemia rat model was made by induced NA (230 mg/kg body weight)-STZ (65 mg/kg body weight) intraperitoneally. Intervention in the form of TTU modified feed (standard feed is substituted with TTU according to the dose) was given for 28 days with dose variations of 2.36 grams, 4.71 grams, and 7.07 grams. Body weight and FBG level were measured before and after the intervention. Data were analyzed statistically using One Way Anova test, Bonferroni test, and uji paired t-test. The body weight of DM rats was significantly lower, and FBG levels were significantly higher than normal rats (KN). Orally administration of TTU for 28 days significantly increased body weight (6.59%-19.54%) and reduced levels of FBG (33.04-54.61%). The changes in FBG levels were in line with the increasing doses of intervention. Purple eggplant flour was able to maintain body weight and reduce the levels of FGB hyperglycemia in rats induced by NA-STZ.

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“…However, but its potential has not been studied for the gum part. Research on the effect of gum on rat blood sugar levels has been carried out on Arabic gum by Nagar (2017) and Wiyono et al (2021), but has never been studied on Moringa gum.…”

Section: Introductionmentioning

confidence: 99%

Moringa oleifera gum effect on blood sugar levels and rat pancreas histology induced by Streptozotocin

Utami,

Fajariyah,

Lelono

et al. 2024

BIO

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Moringa gum is a product that people can use as an anti-hyperglycemic agent. This study aimed to determine the effectiveness of Moringa gum in reducing blood sugar levels and improving the histology structure of the rat pancreas induced by streptozotocin (STZ). This study used 21 male rats divided into 3 groups including control, diabetes (STZ), and diabetes (STZ + 3% Moringa gum). STZ treatment at a single dose (45 mg/kg BW) was given intraperitoneally, while Moringa gum was given through drinking water for 2 weeks. Blood sugar levels were measured on days 0, 7th, 14th, 21st, and 28th. The results showed that STZ administration induced diabetes in rats with blood sugar levels of 487 mg/dL on the 14th day. Moringa gum administration was able to reduce blood sugar levels on days 21st and 28th respectively to 306 and 234 mg/dl. The histology structure of the pancreas of rats treated with gum also showed improvement. This study concludes that Moringa gum is effective in lowering blood sugar levels in rats even though it still does not show normal blood sugar levels, and can repair STZ-induced damage to the histology structure of the rat pancreas.

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Effect of Baluran Gum Arabic on Blood Glucose Level in Diabetic Rat (Rattus Novergicus )

Cited by 3 publications

References 12 publications

The Effect of Neem Gum on the Reduction in Rat Blood Glucose Levels Induced by Streptozotocin

The Effect of Neem Gum on the Reduction in Rat Blood Glucose Levels Induced by Streptozotocin

Potensi Antidiabetik Tepung Terung Ungu (Solanum Melongena L.) pada Tikus Hiperglikemia

Moringa oleifera gum effect on blood sugar levels and rat pancreas histology induced by Streptozotocin

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