Effect of Balloon Valvuloplasty in Patients With Severe Aortic Stenosis on Levels of N-Terminal Pro-B-Type Natriuretic Peptide

Spargias, Konstantinos; Alexopoulos, Elias; Thomopoulou, Sofia; Dimopoulos, Antonis; Manginas, Athanasios; Pavlides, Gregory; Voudris, Vassilis; Karatassakis, George; Athanassopoulos, George; Cokkinos, Dennis V.

doi:10.1016/j.amjcard.2009.05.013

Cited by 7 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, we show direct correlation of NT-pro-BNP, BNP and Osteopontin and the presence of CAS while Fetuin A levels an inverse relation. These results are in concordance with the published literature (9, 17,18, 19 and 20). It is important to note that this is the first study in which the most significant biomarkers used in the staging of CAS have been collectively compared in the same cohort of patients.…”

Section: Discussionsupporting

confidence: 93%

Validation of Plasma Biomarkers in Degenerative Calcific Aortic Stenosis

Ferrari

Sainger

Beckmann

et al. 2010

Journal of Surgical Research

View full text Add to dashboard Cite

Introduction Calcific aortic stenosis (CAS) is the most common acquired valvular disorder in industrialized countries. This study investigates the correlation of different known biomarkers for CAS as a first step towards the development of a panel of biomarkers that can be used in prognostic staging. Methods Venous blood samples were obtained from both patients with CAS scheduled for surgery and healthy individuals. Plasma levels of fetuin-A, NT-proBNP, BNP, Homocysteine and Osteopontin were measured by ELISA. CAS was measured by echocardiography and was defined as an aortic valve area of less than 2.0 cm2. Non-paired t tests were used for comparison. Results CAS was present in 33 subjects (mean age 75.9 years) and absent in 11 subjects (mean age 55.36 years). Individuals with CAS exhibited higher plasma levels of NT-proBNP (1.33 vs 0.73 pmol/ml, p<0.05), BNP fragment (1.47 vs 0.34 ng/ml p<0.05) and Osteopontin (60.79 vs 25.42 ng/ml p<0.05) compared to controls. Fetuin-A levels were lower in individuals with CAS than in healthy controls (0.25 vs 0.34g/l, p<0.05). Asymmetric dimethylarginine (ADMA) were lower (1.08 vs 1.1 μmol/l, p>0.05) while homocysteine levels (20.34±2.14 Vs 19.23±4.19 p>0.05) were higher in the CAS patients. Discussion This study demonstrates a direct correlation of NT-pro-BNP, BNP and Osteopontin and the presence of CAS while Fetuin A showed an inverse correlation. Plasma ADMA and homocysteine levels were comparable in the CAS patients and healthy individuals. This is the first study in which several biomarkers previously studied independently in patients with CAS have been investigated simultaneously in the same study population.

show abstract

Section: Discussionsupporting

confidence: 93%

Validation of Plasma Biomarkers in Degenerative Calcific Aortic Stenosis

Ferrari

Sainger

Beckmann

et al. 2010

Journal of Surgical Research

View full text Add to dashboard Cite

show abstract

“…9 We have recently shown that NT-pro-BNP levels decline by approximately 25% early after contemporary balloon valvuloplasty in high-surgical risk patients with aortic stenosis. 22 The immediate effects of TAVI on the aortic stenosis physiology of our patients are typical of those achieved with this procedure in elderly high-risk populations and the mediumterm total mortality observed is slightly lower to those observed in contemporary TAVI registries. 6,7 The immediate reduction in transvalvular pressure gradient after TAVI apparently eased ventricular wall stress, the strongest stimulus for BNP production and release, and correlated to the reduction in NT-proBNP levels.…”

Section: Discussionsupporting

confidence: 50%

“…NT‐proBNP levels more than double in medically treated patients with aortic stenosis within 1‐year follow‐up and fall to almost one‐third of their baseline values when measured at 1 year after successful valve replacement 9 . We have recently shown that NT‐pro‐BNP levels decline by approximately 25% early after contemporary balloon valvuloplasty in high‐surgical risk patients with aortic stenosis 22 . The immediate effects of TAVI on the aortic stenosis physiology of our patients are typical of those achieved with this procedure in elderly high‐risk populations and the medium‐term total mortality observed is slightly lower to those observed in contemporary TAVI registries 6,7 .…”

Section: Discussionmentioning

confidence: 96%

The Predictive Value and Evolution of N-Terminal Pro-B-Type Natriuretic Peptide Levels Following Transcutaneous Aortic Valve Implantation

Spargias

Polymeros

Dimopoulos

et al. 2011

Journal of Interventional Cardiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…A subsequent increase of BNP after TAVR was associated with higher mortality [24]. Aortic balloon valvuloplasty in severe AS patients could decrease the BNP level [25]. Additionally, BNP 24h post-procedure could predict the 1-year mortality after TAVR [26].…”

Section: Discussionmentioning

confidence: 99%

Association of B-type natriuretic peptide with rapid progression in patients with aortic stenosis

Han¹,

Shi²,

Yang³

et al. 2022

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Rapid progression of aortic stenosis (AS) is associated with poor outcomes, and the impact of B-type natriuretic peptide (BNP) on AS progression remains unknown. Objectives: The purpose of the present study was to investigate the association between BNP level and the AS progression rate. Methods: From January 2016 to June 2021, 200 AS patients with progression who had at least two transthoracic echocardiograms with a maximum interval of 180 days were retrospectively analyzed. Rapid progression of AS was defined as the annual increase of aortic jet velocity (Vmax) ≥0.3 m/s/year. For analyses, both the log-transformed BNP and the BNP ratio were used. The linear regression and binary logistic regression analyses were used to determine the association between BNP and the AS progression. Results: At a median echocardiographic follow-up of 595 days, the annual median (interquartile) progression of Vmax was 0.26 (0.09-0.58) m/s/year. Patients with rapid progression had higher age, log BNP, and higher percentage of diabetes and male gender. Higher tertiles of log BNP and BNP ratio had more rapid increase in Vmax (p = 0.018 and 0.033, respectively). BNP ratio significantly correlated with Vmax progression in univariate and multivariate linear regression analyses (p < 0.001 and p = 0.001, respectively). Moreover, both the univariate and multivariate binary logistic regression analyses showed that the log BNP and BNP ratio were associated with the rapid progression of AS (p < 0.050 for all). Conclusions: Higher BNP was independently associated with the rapid progression of AS.

show abstract

Effect of Balloon Valvuloplasty in Patients With Severe Aortic Stenosis on Levels of N-Terminal Pro-B-Type Natriuretic Peptide

Cited by 7 publications

References 16 publications

Validation of Plasma Biomarkers in Degenerative Calcific Aortic Stenosis

Validation of Plasma Biomarkers in Degenerative Calcific Aortic Stenosis

The Predictive Value and Evolution of N-Terminal Pro-B-Type Natriuretic Peptide Levels Following Transcutaneous Aortic Valve Implantation

Association of B-type natriuretic peptide with rapid progression in patients with aortic stenosis

Contact Info

Product

Resources

About