Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats

Kothandapani, Anbarasi; Vani, G.; Balakrishna, K.; Devi, C. S. Shyamala

doi:10.1016/j.lfs.2005.07.030

Cited by 127 publications

(86 citation statements)

References 50 publications

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“…The in vitro exposure of plasma to cigarette smoke resulted in the destruction of tocopherols, carotenoids, and retinal (Handelman et al 1996). The study revealed depletion in the levels of nonenzymatic antioxidants, such as vitamins C, E and A in the brain of rats exposed to cigarette smoke (Anbarasi et al 2006). In another study, antioxidant (bacoside A) increased the GSH levels in the brain.…”

Section: Discussionmentioning

confidence: 87%

“…Cigarette smoke exposure increased both basal and induced lipid peroxidation in the brain (Anbarasi et al 2006). The sustained release of reactive free radicals from the tar and gas phases of smoke imposes an oxidant stress, promotes lipid peroxidation and consequently perturbs the antioxidant defense system in the vulnerable tissues of smokers (Pryor & Stone 1993).…”

Section: Discussionmentioning

confidence: 99%

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Effect of vitamin E and selenium on antioxidant enzymes in brain, kidney and liver of cigarette smoke-exposed mice

2007

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The present study was conducted to evaluate the protective effects of vitamin E and selenium (Se) application on alteration of antioxidant enzyme activities against cigarette smoking induced oxidative damage in brains, kidneys and liver of mice. Male mice (balb/c) were exposed to cigarette smoke and treated with Se and/or vitamin E. Glutathione transferase (GST), glutathione peroxidase (GPX), glutathione reductase (GRX), superoxide dismutase (SOD) and catalase (CAT) enzyme activities in mice brain, kidney and liver were measured spectrophotometrically. GST, GPX, GRX, SOD and CAT enzyme activities in the brains of smoke-exposed mice were found lower than the enzymes activities of control mice and Se-and vitamin E-treated mice at the end of the three and five months. Opposite to brain, enzyme activities in kidneys and livers of smoke-exposed mice were found higher than the enzymes activities of control mice and Se-and vitamin E-treated mice at the end of the three and five months. Activities of GST, GPX, GRX SOD and CAT in the livers, kidneys and brains of smoke-exposed mice were found statistically different (p < 0.01) compared to control mice and Se-and vitamin E-treated mice. Combined application of vitamin E and Se had an additive protective effect against changing enzymes activities in smoke-exposed mice livers, kidneys and brains at the end of the both application periods. These results suggest that cigarette smoke exposure enhances the oxidative stress, thereby disturbing the tissue antioxidant defense system and combined application of vitamin E and Se protects the brain, kidney and liver from oxidative damage through their antioxidant potential.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Effect of vitamin E and selenium on antioxidant enzymes in brain, kidney and liver of cigarette smoke-exposed mice

2007

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“…Our results are in accordance with previous IJBAR (2013) 04 (11) www.ssjournals.com reports. 18,19 Bhat et al, reported in their study a significant increase in total lipid peroxidation in patients with coronary artery disease they also found a significant increase in total oxidant status and oxidative stress index and significant decrease in total antioxidant status. 20 …”

Section: Discussionmentioning

confidence: 89%

Antioxidant status and level of oxidants in patients of coronary heart disease

Jha¹,

Parchwani²,

Ahmad³

2013

Int J of Biomed & Adv Res

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“…A burning cigarette was introduced through one hole (3 cm) and the other hole (1.5 cm) was used for ventilation. Animals were exposed to CS for 30 minutes, daily for 4 weeks with interval of 10 min between each 10 min exposure, using 3 cigarettes/day/2 rats in each group (Anbarasi et al, 2006).…”

Section: Dose Preparationmentioning

confidence: 99%

“…tremendous increase in the production of ROS (Anbarasi et al, 2006;McCord, 1993;Mohod et al, 2014). However, after prolonged exposure, the toxic effects of cigarette smoke emerge to override the adaptive mechanism of the body tissues, as indicated by a decrement in the levels of these enzymes (Hulea et al, 1994).…”

Section: The Role Of Ficus Virens Ait and Its Novel Bioactive Compoundmentioning

confidence: 99%

Extenuating the role of Ficus virens Ait and its novel bioactive compound on antioxidant defense system and oxidative damage in cigarette smoke exposed rats

Iqbal¹,

Khan²,

Khan³

et al. 2016

Biomed Res Ther

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Abstract-Introduction:Production of free radicals is associated with cigarette smoke (CS) which in turn generates oxidative stress, could be responsible for alterations in the activities of enzymatic and non-enzymatic antioxidants that links with atherosclerosis. Methods: Therefore, the putative preventive effects of F. virens extract and its bioactive compound (F18), n-Octadecanyl-O-α-D-glucopyranosyl(6'→1'')-O-α-D-glucopyranoside were investigated on overall enzyme and non-enzymatic defense system and in oxidative stress CS-exposed rats. Results: The enzymatic activities of hepatic and lung CAT, SOD, Gred and GST in CS exposed rats were significantly decreased, while Gpx activity in CS exposed rats was increased. Similarly, hepatic and lung GSH content was reduced when compared to value of normal control group. Simultaneous administration of FVBM extract (50 and 100 mg/rat) and F18 bioactive compound (1 mg/rat) significantly increases hepatic and lung CAT, SOD, Gred and GST activity as well GSH concentration coupled with decrease in Gpx level in CS-exposed stress rats. Moreover, our histological observations concludes the pulmonary congestion, thickening of interalveolar septa and foci of collapsed alveoli with subsequent dilation of the adjoining alveolar spaces as well as development of large irregular spaces in rats lung exposed to cigarette smoke. Similarly, the liver also showed morphological alterations with congestion in central vein, portal inflammation and necrosis in CS-exposed rats. These morphological changes reversed significantly after treatment with FVBM extract and F18 compound. Conclusion: Thus biochemical and histopathological studies suggested that, FVBM extract and F18 showed its protective nature against CS-exposed rats.

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Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats

Cited by 127 publications

References 50 publications

Effect of vitamin E and selenium on antioxidant enzymes in brain, kidney and liver of cigarette smoke-exposed mice

Effect of vitamin E and selenium on antioxidant enzymes in brain, kidney and liver of cigarette smoke-exposed mice

Antioxidant status and level of oxidants in patients of coronary heart disease

Extenuating the role of Ficus virens Ait and its novel bioactive compound on antioxidant defense system and oxidative damage in cigarette smoke exposed rats

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