Effect of Azithromycin plus Rifampin versus That of Azithromycin Alone on the Eradication of
            <i>Chlamydia pneumoniae</i>
            from Lung Tissue in Experimental Pneumonitis

Wolf, Katerina; Malinverni, Raffaele

doi:10.1128/aac.43.6.1491

Cited by 32 publications

(15 citation statements)

References 18 publications

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“…Experimental infection of mice with C. trachomatis and treatment with doxycycline or azithromycin in combination with rifampicin showed that even though culture-positive results were reduced in treated animals, there was still chlamydial DNA in the tissue (Malinverni et al, 1995;Wolf & Malinverni, 1999). In studies in human patients with C. trachomatis infection, antimicrobial treatment with doxycycline was not capable of eliminating the pathogen from the urinary tract of examined patients (Manhart et al, 2013;Pitt et al, 2013).…”

Section: Discussionmentioning

confidence: 93%

Evaluation of antimicrobial treatment in a bovine model of acuteChlamydia psittaciinfection: tetracycline versus tetracycline plus rifampicin

et al. 2014

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Antimicrobial treatment of chlamydial infections is known to be of limited efficacy. In this study, effects of doxycycline (D), usually the drug of choice, were compared with the combined therapy of doxycycline and rifampicin (R) in a bovine model of respiratory Chlamydia psittaci infection. After intrabronchial inoculation of the pathogen, 30 animals were assigned to five groups (n = 6 per group): untreated controls, monotherapy with D (5 mg kg(-1)day(-1) or 10 mg kg(-1)day(-1)), and combination therapy of D and R (600 mg day(-1)). Treatment continued until day 14 post inoculation (d.p.i.). Clinical signs, inflammatory markers, and pathological findings confirmed successful infection in all animals. Reisolation of the pathogen was possible in 4/6 untreated animals and in 4/12 animals treated with D alone until 4 d.p.i., but in none of the calves of the two D + R groups. Pathogen detection was possible in all animals without significant differences among groups. Severity of disease and time course of its resolution, assessed by clinical and pathological findings as well as inflammatory parameters, were not significantly different between untreated controls and calves receiving D alone or in combination with R. Regardless of the treatment regimen, all groups recovered clinically and cleared the infection within 2 weeks.

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Section: Discussionmentioning

confidence: 93%

Evaluation of antimicrobial treatment in a bovine model of acuteChlamydia psittaciinfection: tetracycline versus tetracycline plus rifampicin

et al. 2014

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“…The combination of azithromycin plus rifampicin showed the highest activity and produced higher rates of eradication of C. pneumoniae than azithromycin [16] and amoxicillin [17] in the chronic course of pneumonitis. Interestingly, it was also reported that the same combination of azithromycin plus rifampicin was more efficient than azithromycin or rifampicin alone [12].…”

Section: Discussionmentioning

confidence: 97%

“…The antibacterial combinations used as compared with single-drug had shown to be more active in C. pneumoniae and C. trachomatis [12,16,17]. Presently, the use of antibacterial combinations seems to be a way of treating genital chlamydial infection.…”

Section: Introductionmentioning

confidence: 94%

Single-drug or combined antibacterial therapy in the treatment of patients with chronic prostatitis and Chlamydia trachomatis?

Smelov

Gorelov

Smelova

et al. 2004

International Journal of Antimicrobial Agents

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“…Hammerschlag and her colleagues described three patients who remained culture positive for C. pneumoniae over an 11-mo period despite treatment with either one or two courses of tetracycline or doxycycline of 10-21 d duration (30). Wolf and Malinverni innoculated mice with C. pneumoniae and treated the pneumonitis with azithromycin alone or in combination with rifampicin for 3 d. Following treatment, C. pneumoniae DNA was detected in 12 of 13 lungs treated with azithromycin alone but in only 6 of 16 lungs treated with the combination of azithromycin and rifampicin (31). In our study, treatment with roxithromycin may have suppressed infection with C. pneumoniae rather than eradicating it.…”

Section: Adverse Eventsmentioning

confidence: 94%

Trial of Roxithromycin in Subjects with Asthma and Serological Evidence of Infection withChlamydia pneumoniae

Black

Blasi

Jenkins

et al. 2001

Am J Respir Crit Care Med

155

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An association has been reported between chronic infection with Chlamydia pneumoniae and the severity of asthma, and uncontrolled observations have suggested that treatment with antibiotics active against C. pneumoniae leads to an improvement in asthma control. We studied the effect of roxithromycin in subjects with asthma and immunoglobulin G (IgG) antibodies to C. pneumoniae > or = 1:64 and/or IgA antibodies > or = 1:16. A total of 232 subjects, from Australia, New Zealand, Italy, or Argentina, were randomized to 6 wk of treatment with roxithromycin 150 mg twice a day or placebo. At the end of 6 wk, the increase from baseline in evening peak expiratory flow (PEF) was 15 L/min with roxithromycin and 3 L/min with placebo (p = 0.02). With morning PEF, the increase was 14 L/min with roxithromycin and 8 L/min with placebo (NS). In the Australasian population, the increase in morning PEF was 18 L/min and 4 L/min, respectively (p = 0.04). At 3 mo and 6 mo after the end of treatment, differences between the two groups were smaller and not significant. Six weeks of treatment with roxithromycin led to improvements in asthma control but the benefit was not sustained. Further studies are necessary to determine whether the lack of sustained benefit is due to failure to eradicate C. pneumoniae.

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Effect of Azithromycin plus Rifampin versus That of Azithromycin Alone on the Eradication of Chlamydia pneumoniae from Lung Tissue in Experimental Pneumonitis

Cited by 32 publications

References 18 publications

Evaluation of antimicrobial treatment in a bovine model of acuteChlamydia psittaciinfection: tetracycline versus tetracycline plus rifampicin

Evaluation of antimicrobial treatment in a bovine model of acuteChlamydia psittaciinfection: tetracycline versus tetracycline plus rifampicin

Single-drug or combined antibacterial therapy in the treatment of patients with chronic prostatitis and Chlamydia trachomatis?

Trial of Roxithromycin in Subjects with Asthma and Serological Evidence of Infection withChlamydia pneumoniae

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