Effect of atropine-induced flow rate depression on the composition of unstimulated human parotid fluid

Shannon, Ira L.; Suddick, Richard P.; Chauncey, Howard H.

doi:10.1016/0003-9969(69)90167-8

Cited by 31 publications

(15 citation statements)

References 20 publications

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“…The results of the present study indicate that, in unstimulated parotid fluid, as flow rate is decreased, not only is there an increase in the number of particles present per unit volume of saliva, but also a net increase in the mass of each unit volume of exiting fluid. These observations are in agreement with our recent findings in 300 subjects who provided unstimulated parotid fluid under the usual conditions and a second sample after dosage with atropine [13]. The flow rate mean de creased from 0.054 ml/min to 0.018 ml/min and highly significant in creases were found for potassium, chloride, calcium, magnesium, phos phorus, amylase, acid phosphatase, uric acid, urea nitrogen, total protein, glucose, total solids, specific gravity, and osmolality.…”

Section: Discussionsupporting

confidence: 83%

Specific Gravity and Osmolality of Human Parotid Fluid

Shannon¹

1969

Caries Res

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Section: Discussionsupporting

confidence: 83%

Specific Gravity and Osmolality of Human Parotid Fluid

Shannon¹

1969

Caries Res

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“…Such a mechanism could ex plain the higher concentration of F" in unstimulated saliva. This type of proportionate water and sodium reabsorption could also explain the in crease in concentration of virtually all constituents of saliva (except sodium) which we have found to occur during atropine-induced depression of secretion [Shannon et al, 1969].…”

Section: Discussionmentioning

confidence: 88%

Effect of Rate of Gland Function on Parotid Saliva Fluoride Concentration in the Human

Shannon¹,

Suddick²,

Edmonds³

1973

Caries Res

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A series of experiments were carried out to determine the effect of the rate of gland function on parotid saliva fluoride levels in the human. Means for fluoride for stimulated parotid saliva ranged from 0.012 to 0.02 ppm. These are much lower levels than those previously reported for whole saliva and support other electrode analyses recently reported. In a 3-hour experiment involving continuous exogenous stimulation, salivary fluoride levels showed no alterations suggestive of depletion. Significantly higher levels of fluoride were found in parotid saliva collected without exogenous stimulation. It is suggested that the glandular mechanisms responsible for these observations are purely passive in nature with the fluoride ion probably moving in bulk flow with the fluid of secretion as it is generated by the secretory cells. However, the exact mechanisms which govern absolute saliva fluoride levels remain obscure.

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“…The potassium concentration in unstimulated submandibular saliva tends to be considerably lower than that in unstimulated parotid saliva. Alternatively, since at low flow rates potassium concentration is inversely related to flow rate (Shannon, Suddick & Chauncey, 1969), the peak flow rate in the middle of the afternoon may reduce the expected potassium peak.…”

Section: I 539mentioning

confidence: 99%

Circadian rhythms in human salivary flow rate and composition

Dawes¹

1972

The Journal of Physiology

538

368

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SUMMARY1. Unstimulated whole saliva and parotid saliva stimulated at a constant flow rate of 1-0 ml./min were collected from eight subjects at about 07.00, 11.00, 14.00, 17.00 and 22.00 hr and oral temperature was recorded several times daily for time spans of between 4 and 26 days. A leastsquares cosine wave was fitted to the data to test for the presence and characteristics of circadian rhythms. 2. Estimates of mean level, amplitude, acrophase and period were obtained for different components and the results were subjected to cosinor analysis.3. Unstimulated whole saliva showed significant circadian rhythms in flow rate and in the concentrations of sodium and chloride but not in protein, potassium, calcium, phosphate or urea.4. Stimulated parotid saliva showed significant circadian rhythms in the concentrations of protein, sodium, potassium, calcium and chloride but not in phosphate or urea 5. Oral temperature showed a circadian rhythm which, like the salivary rhythms, was of a 24.0 hr periodicity.

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Effect of atropine-induced flow rate depression on the composition of unstimulated human parotid fluid

Cited by 31 publications

References 20 publications

Specific Gravity and Osmolality of Human Parotid Fluid

Specific Gravity and Osmolality of Human Parotid Fluid

Effect of Rate of Gland Function on Parotid Saliva Fluoride Concentration in the Human

Circadian rhythms in human salivary flow rate and composition

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