Effect of atorvastatin and methotrexate on solid Ehrlich tumor

Kabel, Ahmed M.; Abdel-Rahman, Mohamed Nabih; El‐Sisi, Alaa E.; Haleem, M.; Ezzat, Nadia M.; Rashidy, Mohamed A. El

doi:10.1016/j.ejphar.2013.04.049

Cited by 45 publications

(25 citation statements)

References 48 publications

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“…These results were in agreement with Kabel et al (2013) and Zahran et al (2008). Oxidative stress was involved in cellular processes ranging from apoptosis to cell proliferation and carcinogenesis.…”

Section: Discussionsupporting

confidence: 93%

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Effect of metformin and adriamycin on transplantable tumor model

et al. 2015

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Section: Discussionsupporting

confidence: 93%

“…Group (1): Ehrlich tumor cells were implanted subcutaneously into the right thigh of the hind limb of mice (Kabel et al, 2013).…”

Section: Classification Of Animalsmentioning

confidence: 99%

Effect of metformin and adriamycin on transplantable tumor model

et al. 2015

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“…These results were in agreement with Kabel et al [20] and Metwally et al [21]. Oxidative stress was involved in cellular processes including apoptosis, DNA damage, cellular proliferation and carcinogenesis.…”

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confidence: 83%

The Possible Chemosensitizing Effect of Different Doses of Indol-3-Carbinol on Transplantable Tumor Model Treated with Doxorubicin

Adwas

Elkhoely

Kabel

et al. 2016

IJPPE

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Abstract.Background: Ehrlich carcinoma is a transplantable tumor model used frequently in cancer studies. Doxorubicin (DOX) is one of the anthracyclines that is frequently used in treatment of various types of malignancies including breast, prostate and lung cancer. Indole-3-carbinol (I3C) is a phytochemical that was suggested to have potent anti-tumor and chemosensitizing effects. Objective: To detect the possible chemosensitizing effects of different doses of I3C on solid Ehrlich carcinoma (SEC) treated with DOX in mice.

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“…As a reduction agent, vitamin C donates one electron, forming unreactive semi-dehydroascorbate and undergoes the disproportionation reaction that forms unstable dehydroascorbate. Dehydroascorbate will be degraded into oxalic acid and threonic acid (Kabel et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…Catalase (CAT) or H 2 O 2 oxydoreductase decomposes hydrogen peroxide in two models of catalytic reaction, which are the catalytic activity (2H 2 O 2 → O 2 + 2H 2 O) and peroxidative activity (H 2 O 2 + AH 2 → A + 2H 2 O). Glutathione peroxidase plays a role as an enzyme that catalyzes the breakdown of hydrogen peroxide and organic hydroperoxides (Kabel et al, 2013). These enzymatic activities are also biomarkers for oxidative status (Kabel, 2014).…”

Section: Introductionmentioning

confidence: 99%

<b>Synergetic effect of chitosan and vitamin C on the oxidative enzyme status in rat exposed to lead acetate

Marianti

Mahatmanti

2018

Acta Sci. Biol. Sci.

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This article discusses the research results on the synergetic effect of chitosan and vitamin C in overcoming free radical effect due to blood lead (Pb 2+ ) accumulation. Blood lead level and enzymatic activities of superoxide dismutase (SOD), catalase oxidase (CAT), and Glutathione peroxidase (GPx) were used as the main parameters. Thirty adult male albino rats were divided into six groups. Group 1 was normal control group; group 2 was the negative control group treated with lead acetate at 175 mg kg -1 body weight (BW). Group 3 was treated with 64 mg kg -1 BW of chitosan day -1 . Group 4, 5, and 6 were treated with chitosan and vitamin C combination at the dose of 100, 200, and 300 mg kg -1 BW, respectively. All groups were inducted using 175 mg kg -1 BW of Pb-acetate, excluding control group. Results showed that chitosan and vitamin C treatment at the dose of 300 mg kg -1 BW decreased blood Pb 2+ level in rats exposed to Pb-acetate. The combination also significantly increased enzymatic activities from SOD, CAT, and GPx compared to the other groups. In conclusion, the combination of chitosan and vitamin C could elevate the several antioxidative enzymes activities in Pb-acetate induced rats.Keyword: chitosan; antioxidative enzyme; lead-induced rat.Efeito sinérgico do chitosano e da vitamina C no estado da enzima oxidativa em ratos expostos ao acetato de chumbo RESUMO. Este artigo discute os resultados da pesquisa sobre o efeito sinérgico da quitosana e da vitamina C na superação do efeito dos radicais livres devido ao acúmulo de chumbo no sangue (Pb 2+ ). O nível de chumbo no sangue e as atividades enzimáticas de superóxido dismutase (SOD), catalase oxidase (CAT) e glutationa peroxidase (GPx) foram utilizados como parâmetros principais. Trinta ratos albinos adultos foram divididos em seis grupos. Grupo 1 foi grupo controle normal; o grupo 2 foi o grupo controle negativo tratado com acetato de chumbo a 175 mg kg -1 de peso corporal (PC). O grupo 3 foi tratado com 64 mg kg -1 PC de quitosana dia -1 . Os grupos 4, 5 e 6 foram tratados com combinação de quitosana e vitamina C nas doses de 100, 200 e 300 mg kg -1 PC, respectivamente. Todos os grupos foram induzidos usando 175 mg kg -1 de PC de Pb-acetato, excluindo o grupo controle. Os resultados mostraram que o tratamento com quitosana e vitamina C na dose de 300 mg kg -1 PC diminuiu o nível de Pb 2+ no sangue em ratos expostos ao acetato de Pb. A combinação também aumentou significativamente as atividades enzimáticas de SOD, CAT e GPx em comparação com os outros grupos. Em conclusão, a combinação de quitosana e vitamina C pode elevar as várias atividades das enzimas antioxidativas em ratos induzidos com acetato de Pb.Palavras-chave: enzima antioxidante; quitosana; rato induzido por chumbo.

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Effect of atorvastatin and methotrexate on solid Ehrlich tumor

Cited by 45 publications

References 48 publications

Effect of metformin and adriamycin on transplantable tumor model

Effect of metformin and adriamycin on transplantable tumor model

The Possible Chemosensitizing Effect of Different Doses of Indol-3-Carbinol on Transplantable Tumor Model Treated with Doxorubicin

<b>Synergetic effect of chitosan and vitamin C on the oxidative enzyme status in rat exposed to lead acetate

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