Effect of Atiko (&lt;i&gt;Aframomum sceptrum&lt;/i&gt;) and African nutmeg (&lt;i&gt;Monodora myristica&lt;/i&gt;) on reduced glutathione, uric acid levels and liver marker enzymes in streptozotocin-induced diabetic rats

George, BO; Osioma, E; Falodun, Abiodun

doi:10.4314/ejbmb.v28i2.60794

Cited by 5 publications

(3 citation statements)

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“…It is popularly called ataiko and is known for its ability to enhance taste and food aroma and improve several alcoholic and non-alcoholic beverages among Urhobos and Uk-wuanis of Delta State Nigeria [12,13]. It has been widely researched and reported to be rich in phytochemicals and possess several ethnopharmocological properties; thus, it is reported for its efficacy in the traditional herbal management of malaria [14], wound healing, management of postnatal malignancies after delivery [15] and the treatment of several models of diabetes mellitus [16,17]. The efficacy of A. sceptrum extracts has been explored in the preservation of food products like meat and the oxidative deterioration of palm oil [18,19].…”

Section: Problem Statement and Analysis Of The Latest Researchmentioning

confidence: 99%

Possible Mechanism of Aframomum Sceptrum Extracts Mediated Modulation of Renal Function after Monosodium Glutamate Exposure

2019

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The objective of the research was to explain the possible mechanism of an earlier reported role of Aframomum sceptrum extract in the modulation of renal function parameters in monosodium glutamate-induced toxicity. Materials and Methods. Similar experimental methods previously reported by us in Ogbeke et al., (2016) were maintained. Results. Monosodium glutamate administration led to a significant elevation of levels of serum and kidney lipid peroxidation due to decrease in the levels of serum and kidney antioxidant enzyme, super oxide dismutase, catalase, gluthathione peroxidase and gluthathione. There was observed increase in oxidative enzyme, aldehyde oxidase, sulphite oxidase, xanthine oxidase and monoamine oxidase activities in serum and kidney after monosodium glutamate consumption. Aframomum sceptrum treatment significantly regulated all altered indices. Conclusions. The study concluded that the ability of Aframomum sceptrum extract to modulate renal function parameters in monosodium glutamate-induced toxicity is dependent on its efficacy in the induction and mobilization of antioxidant defense armory via the increased synthesis of tissue and serum enzymatic and non-enzymatic antioxidants, as well as improved oxidative enzyme activities that mediates the quenching of rising aldehydes and sulfoxides, N-oxides and aromatic oxides within the kidney.

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Section: Problem Statement and Analysis Of The Latest Researchmentioning

confidence: 99%

Possible Mechanism of Aframomum Sceptrum Extracts Mediated Modulation of Renal Function after Monosodium Glutamate Exposure

2019

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“…4 They are considered to be safe, effective, and less toxic and with strong antioxidant activity. 4,5 Physalis angulata L. belongs to the Solanaceae family, which is locally named as "Tầm bóp, thù lù, lồng đèn" in Vietnam and found in the Brazilian Amazon Forest and other tropical countries of Africa, America and Asia. It grows up to 1 m with a small stem, creamcoloured flowers and light yellowish-orange edible fruits wrapped by…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Anti-Diabetic and Antioxidant Activities of Physalis angulata Extract

Nguyen¹,

Vo²

2020

TJNPR

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a layer of leaves. Fruits from the P. angulata are used as food in several countries. P. angulata has an important role in the remedy of inflammatory conditions such as asthma, hepatitis, dermatitis, rheumatism and treatment of several health disorders, such as cold, cough, fever, pain, malaria and neurological diseases. 6-8 Recently, the phytochemistry of P. angulata has been reported and found to contain glucocorticoids, flavonoids, withanolides and physalins. 9 Similarly, numerous biological activities of P. angulata such as antinociceptive, immunosuppressive, anti-protozoal, antineoplastic and antiinflammatory effects have been determined. 9 So far, P. angulata has been locally used as a traditional medicine for the remedy of hyperglycemia in Vietnam. Moreover, the anti-diabetic activity of P. angulata fruit has been demonstrated recently. 10 However, the studies regarding antidiabetic activity of the leaves and stem of P. angulata are still limited. Therefore, the present study was designed to investigate the role of the leaves and stem of P. angulata on antidiabetic activity using an in vitro model. Materials and Methods Materials The leaves and stem of Physalis angulata were collected from Tay Ninh province, Vietnam in March, 2019. P. angulata was authenticated by Do Huy Bich et al. 11 Alpha-amylase from Bacillus licheniformis (A4582) was purchased from Sigma-Aldrich (USA). Ethanol was purchased from Xilong (China). Acarbose and metformin were purchased from Long Chau pharmacy store at district 7, Ho Chi

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“…Aframomum sceptrum (Family-zingiberaceae, local name: Urioma/Ataiko) is a native spice commonly use to enhance cooking flavour, aroma, and palatability especially in the southern part of Nigeria, particularly by the Urhobos, Itsekiri's and Ijaws of Delta State [10]. The antiplasmodial activity of Aframomum sceptrum has been reported [11,12].…”

Section: Introductionmentioning

confidence: 99%

Changes in Oxidative Indices in Plasmodium Berghei Infected Mice Treated with Aqueous Extract of Aframomum Sceptrum

O¹,

Okpoghono²,

Osioma³

et al. 2012

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Malaria is associated with increased production of free radicals whose activities be reduced by antioxidants.This present study investigated the antioxidant ability of the aqueous extract of Aframomum sceptrum. Adult albino male mice, eight weeks old, weighing 15g-25g and divided into 6 groups of 6 mice per group were used for the experiment. Mice were inoculated intraperitoneally with 0.1ml parasitized blood suspension and parasitemia assessed by thin blood films stained with Geimsa stain. Aqueous extract of Aframomum sceptrum was orally administered at different doses (250mg/kg.wt and 350mg/kg b.wt daily) to both normal and malaria infected mice for a period of 4days. Blood reduced glutathione, hematocrit, liver reduced glutathione, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and lipid peroxidation levels were estimated. Significant (p<0.05) reduction in blood reduced glutathione, hematocrit and decrease activities of liver SOD, CAT, GPx and GSH was observed in parasitized control when compared with normal control mice. However oral administration of Aframomum sceptrum significantly (p<0.05) increased hematocrit and blood reduced glutathione content of parasitized mice. Enzymatic and non-enzymatic antioxidants (SOD, CAT, GSH and GPx) activities were also enhanced in a dose dependent manner of spice administration. Reduction in lipid peroxidation (malondialdehyde) level was also observed in the liver of parasitized mice receiving the spice treatment. These results suggest that aqueous extract of Aframomum sceptrum may contribute to the protection of malaria infected mice against oxidative damage by improving antioxidant status in a dose dependent manner.

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Effect of Atiko (<i>Aframomum sceptrum</i>) and African nutmeg (<i>Monodora myristica</i>) on reduced glutathione, uric acid levels and liver marker enzymes in streptozotocin-induced diabetic rats

Cited by 5 publications

References 0 publications

Possible Mechanism of Aframomum Sceptrum Extracts Mediated Modulation of Renal Function after Monosodium Glutamate Exposure

Possible Mechanism of Aframomum Sceptrum Extracts Mediated Modulation of Renal Function after Monosodium Glutamate Exposure

Investigation of the Anti-Diabetic and Antioxidant Activities of Physalis angulata Extract

Changes in Oxidative Indices in Plasmodium Berghei Infected Mice Treated with Aqueous Extract of Aframomum Sceptrum

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