Investigation of the Anti-Diabetic and Antioxidant Activities of Physalis angulata Extract

Abstract

a layer of leaves. Fruits from the P. angulata are used as food in several countries. P. angulata has an important role in the remedy of inflammatory conditions such as asthma, hepatitis, dermatitis, rheumatism and treatment of several health disorders, such as cold, cough, fever, pain, malaria and neurological diseases. 6-8 Recently, the phytochemistry of P. angulata has been reported and found to contain glucocorticoids, flavonoids, withanolides and physalins. 9 Similarly, numerous biological activities of P. angulata such as antinociceptive, immunosuppressive, anti-protozoal, antineoplastic and antiinflammatory effects have been determined. 9 So far, P. angulata has been locally used as a traditional medicine for the remedy of hyperglycemia in Vietnam. Moreover, the anti-diabetic activity of P. angulata fruit has been demonstrated recently. 10 However, the studies regarding antidiabetic activity of the leaves and stem of P. angulata are still limited. Therefore, the present study was designed to investigate the role of the leaves and stem of P. angulata on antidiabetic activity using an in vitro model. Materials and Methods Materials The leaves and stem of Physalis angulata were collected from Tay Ninh province, Vietnam in March, 2019. P. angulata was authenticated by Do Huy Bich et al. 11 Alpha-amylase from Bacillus licheniformis (A4582) was purchased from Sigma-Aldrich (USA). Ethanol was purchased from Xilong (China). Acarbose and metformin were purchased from Long Chau pharmacy store at district 7, Ho Chi

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