Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion

Okada, Mieko; Falcão, Luiz Fernando R.; Ferez, David; Martins, José Luiz; Errante, Paolo Ruggero; Rodrigues, Francisco Sandro Menezes; Caricati‐Neto, Afonso; Marinho, Márcia; Fenelon, Guilherme; Oliveira-Júnior, Itamar Souza

doi:10.1590/s0102-865020170110000008

Cited by 7 publications

(5 citation statements)

References 31 publications

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“…Okada et al [45] demonstrated through an animal model of intestinal ischemia and reperfusion (IRI) that there is a direct relationship between increases in malondialdehyde (MDA), reactive oxygen species (ROS) and TNF-alpha and cardiac injuries, as the study demonstrated that the MDA content and TNF-alpha quantified from hearts obtained from animals belonging to the Sham group (shamoperated) was statistically lower when compared with hearts from animals in the control group, that is, animals treated with 0.9% saline solution and subjected to IRI. These results corroborate that the antioxidant and anti-inflammatory effects of EPI may be responsible for the decrease in AVB and LET in animals treated with EPI and subsequently subjected to the CIR protocol.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Effect of Epiisopiloturine, an Imidazole Alkaloid from <em>Pilocarpus microphyllus</em>, in Rats Submitted to Cardiac Ischemia and Reperfusion

De Marqui Moraes,

Tallo,

Lima

et al. 2023

Preprint

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Acute myocardial infarction (AMI), which is characterized by severe and fatal arrhythmias resultant from cardiac ischemia/reperfusion (CIR), is the leading cause of morbidity and mortality in the world. Considering that epiisopiloturin (EPI), an imidazole alkaloid found in the leaves of Pilocarpus microphyllus produded anti-inflammatory and antioxidant effects in an animal model of peritonitis, paw edema and peritonitis in mice, we decided to investigate the potential cardioprotective activity of EPI in animal model of CIR. Then, adult rats submitted to CIR pretreated with EPI 10 mg/kg (EPI10+CIR group) or 15 mg/kg (EPI15+CIR group) were compared to control animals submitted to CIR treated with saline solution 0.9% (CIR group). To evaluate the incidence of ventricular arrhythmias (VA), atrioventricular block (AVB) and lethality (LET) induced by CIR in these rats, the ECG analysis was performed. Serum levels of cardiac damage markers, total creatine kinase (CK) and CK-MB, were measured. The results showed that the AVB incidence was reduced from 80% to 30%, and LET incidence was reduced from 70% to 20%, compared to CIR group. Serum levels of LDH, total CK and, CK-MB was similar in all groups studied. These results indicate that the treatment with EPI (15 mg/kg, IV) before CIR was effective to produce cardioprotective effects. Thus, the use of EPI could be a promisse strategy to reduce the incidence of severe and fatal arrhythmias associated with AMI.

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Section: Discussionmentioning

confidence: 99%

Cardioprotective Effect of Epiisopiloturine, an Imidazole Alkaloid from <em>Pilocarpus microphyllus</em>, in Rats Submitted to Cardiac Ischemia and Reperfusion

De Marqui Moraes,

Tallo,

Lima

et al. 2023

Preprint

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“…[ 12 ] used this classification to show the efficiency of diltiazem plus SOD on IRI [ 12 ] . In another study, Okada et al investigated the protective effect of atenolol on myocardial cells in regard to the histopathological classification abovementioned [ 13 ] . In the present study, we found significantly less histopathological damage in Wistar rats’ myocytes when cilostazol was used ( Figures 1 and 2 ).…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Effect of Cilostazol on Ischemia-Reperfusion Injury Model

Şahın¹,

Baytaroğlu²,

Sevgili³

2022

Braz J Cardiovasc Surg

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Introduction To clarify the potential protective role of cilostazol on rat myocardial cells with ischemia-reperfusion injury (IRI) models. Methods The study was conducted with three groups of 10 Wistar rats (control group, rats without any coronary ischemia; sham group, rats with coronary ischemia but without cilostazol administration; and cilostazol group, rats with coronary ischemia and cilostazol administration). The level of myocardial injuries was measured by analyzing cardiac troponin T and creatine kinase MB levels in blood samples. In tissue samples, adenosine triphosphate (ATP), nitric oxide, superoxide dismutase (SOD), and malondialdehyde were used to determine the amount of tissue damage. Tissues were stained with hematoxylin-eosin method, and samples were examined under light microscope. Results The mean level of ATP was 104.4 in the cilostazol group and 149.1 in the sham group ( P =0.044). SOD level was significantly higher in the cilostazol group than in the sham group (2075.3 vs . 1783.7, P =0.043). According to histopathological examination, all samples were classified as G0 in the control group. In the sham group, one sample was categorized as G1, six samples as G2, and three samples as G3. In the cilostazol group, nine samples and one sample were categorized as G1 and G2, respectively ( P =0.011). Conclusion Cilostazol has beneficial effects on Wistar rats’ myocardial cells in regard to decreasing inflammatory process, necrosis, and fibrosis. Our findings revealed that the use of cilostazol significantly decreased ATP and increased SOD levels in Wistar rats’ myocardial cells after IRI.

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“…The bowel is sensitive to ischemia because of its high metabolic activity 19 ; resulting in worsening of wound healing after anastomoses 5.7 , increased fistulas tax, and difficulty in adequate nutrients’ absorption, causing malnutrition, anemia and diarrhea. It is one of the main sources of bacteria causing sepsis, which happens with the breakdown of the intestinal barrier allowing wide bacterial translocation 17 .…”

Section: Introductionmentioning

confidence: 99%

Effect of Copaiba Oil in Intestinal Mucosa of Rats Submitted to Hypovolemic Shock

Teixeira

Costa

Calvo

et al. 2019

ABCD, arq. bras. cir. dig.

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Background: Hypovolemic shock is a common disease in polytrauma patients and may develop ischemia in various organs, increasing morbidity and mortality. The bowel is usually most affected by this condition. Aim: To evaluate the effects of copaiba oil on the intestinal mucosa’s injury of rats submitted to hypovolemic shock. Method: Fifteen rats were divided into three groups: sham - simulated surgery; ischemia - animals submitted to hypovolemic shock; and copaiba - animals submitted to hypovolemic shock previously treated with copaiba oil. Mean blood pressure, arterial blood gas after shock induction, degree of intestinal lesion and villus length were evaluated. Results: The sham presented the lowest values of lactate and PaCO2 and the highest values of mean arterial pressure, pH and bicarbonate in relation to the other groups. The degree of mesenteric lesion was zero in the sham group; 3.00±1.00 in the ischemia group; and 3.00±0.71 in the copaiba group. The villus length was 173.60±8.42 in the sham, 142.77±8.33 in the ischemia and 143.01±9.57 in the copaiba group. There was a significant difference between the sham and the other groups (p<0.05); however, there not significant difference between groups Ischemia and copaiba. Conclusion: Administration of copaiba oil did not reduce the intestinal mucosa lesion of rats after hypovolemic shock.

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Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion

Cited by 7 publications

References 31 publications

Cardioprotective Effect of Epiisopiloturine, an Imidazole Alkaloid from <em>Pilocarpus microphyllus</em>, in Rats Submitted to Cardiac Ischemia and Reperfusion

Cardioprotective Effect of Epiisopiloturine, an Imidazole Alkaloid from <em>Pilocarpus microphyllus</em>, in Rats Submitted to Cardiac Ischemia and Reperfusion

Cardioprotective Effect of Cilostazol on Ischemia-Reperfusion Injury Model

Effect of Copaiba Oil in Intestinal Mucosa of Rats Submitted to Hypovolemic Shock

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