Effect of aspirin on random pattern flap survival in rats

Enhancement of dorsal random-pattern skin flap survival in rats with topical lidocaine and prilocaine (EMLA): Enhancement of flap survival by EMLA

“…Various pharmacologic agents have been investigated for their efficacy in preventing or reversing skin flap ischemia. Sympatholytics, vasodilators, calcium channel blockers, hemorheological agents, prostaglandin inhibitors, anticoagulants, glucocorticoids, and free radical scavengers are among the drugs thought to be beneficial for flap survival [1][2][3][4][5][6][7]. Although they are beneficial to some extent, the major drawback associated with these substances is the need for systemic application, at relatively high doses, to achieve significant improvements in flap survival, with increased possibilities of potential systemic side effects.…”

Efficacy of postoperative steroids on ischemic skin flap survival in rats

“…Corticosteroids have been used to improve the flap survival as have many other pharmacological agents [1,3,9,10,11,12,15,17]. However, previous use of corticosteroids in random skin flaps has produced controversial results [2,3,4,9,10,11].…”

Effects of clopidogrel and high dose aspirin on survival of skin flaps in rats

“…Aspirin has been widely used in reconstructive surgery [3] but no effect on survival has yet been shown [2,15]. One report showed that aspirin increases dermal circulation in experimental burns [6], but in contrast [1,2,4,10 Á/13,15 Á/19] aspirin alone gave improved survival over controls [2,7,8]. Aspirin acts as an irreversible inhibitor of cyclo-oxygenase, which leads to subsequent inhibition of platelet thromboxane A2, a potent platelet aggregator and vasoconstrictor; and to prostacyclin, a potent vasodilator and inhibitor of platelet aggregation.…”

“…There are many reports about agents used to improve the survival of flaps [1,2,7,8,14], and in this study we investigated the effectiveness of the use of high doses of aspirin and clopidogrel. Pharmacological agents have been the focus of much research into improving survival of flaps.…”

“…One report has shown that aspirin increases dermal circulation in laboratory animals with experimental burns [6]. Recent studies have shown that aspirin improves survival, and its beneficial effect comes from its antiaggregating effect, combined with its vasodilatory and antiinflammatory effects [2,7,8].…”