Effect of Aspartame in Diabetic Rats

Editorial: Childhood Obesity: too Much, too Little, too Late

“…Another related issue is substituting low calorie, aspartame-sweetened beverages for sugar-sweetened beverages. Researchers at Wayne State University report data from rat models (Sardesai, Holliday, Kumar, & Dunbar, 1986) that suggest when the brain "perceives" sweetness, appetite is triggered, resulting in eating more in conjunction with the consumption of the artificially-sweetened beverage. Replacing the sugar or artificial sweetened drinks with 100% juice is not the solution either since data suggests that the juice may dampen a child's appetite for solids, which are better sources of iron, thus rendering the child obese, yet anemic (Lisshitz, 1993;Lisshitz, 1996).…”

Dietary Phenylalanine and Brain Function

“…Shibata et al (1975) have shown that excess phenylalanine in the diet caused increased urinary excretion of xanthurenic acid, a tryptophan metabolite, which has been claimed to have diabetogenic action. We have reported (Sardesai et al 1986) that aspartame does affect tryptophan metabolism.…”