Effect of Ashwagandha (<i>Withania somnifera</i>) supplementation in<i>Salmonella gallinarum</i>infected broilers

Kumari, Divya; Mishra, S.K.; Lather, Deepika; Kumari, Mamta; Sharma, Ravinder

doi:10.5958/0973-970x.2015.00033.4

Cited by 3 publications

(5 citation statements)

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“…Furthermore, the significantly higher mean SI of E. coli antigen-driven lymphocyte proliferation responses in group B2 as compared with group A2 suggests that the immune system was less compromised because of E. coli infection in group B2. Enhanced cell-mediated immune response due to supplementation of WSR powder has also been reported by other workers in the broiler chicken ( Akotkar et al., 2007 , Kumari et al., 2015a ) and rats ( Gupta et al., 2006 ). Raghavan et al.…”

Section: Discussionsupporting

confidence: 70%

“…The differences in the severity of hepatic and cardiac lesions between the control infected and WSR supplemented infected group might be because of antioxidant principles of W. somnifera such as withanolides, which reduces lipid peroxidation, improves antioxidant status ( Bharavi et al., 2010 ), antilipoperoxidative activity ( Bhattacharya et al., 2001 , Hosny and Farouk, 2012 ), and antiinflammatory activity ( Mahmoud et al., 2012 ), which work together to reduce the cellular injury in these organs. The hepatoprotective and cardioprotective potential of WSR has also been demonstrated by different workers in rats/mice ( Mohanty et al., 2004 , Harikrishnan et al., 2008 , Kaithwas et al., 2011 ) and chickens ( Waihenya et al., 2002 , Kumari et al., 2015a ). The recovery of the lesions in the spleen and bursa of Fabricius in WSR–supplemented infected group indicates an immunomodulatory effect of WSR.…”

Section: Discussionmentioning

confidence: 68%

“…(2013) reported reversal of enrofloxacin-induced immunosuppression in broilers because of supplementation of crude extract of W. somnifera. Similarly, enhanced humoral immune response in Salmonella gallinarum –infected broiler chicks because of the administration of WSR has also been reported ( Kumari et al., 2015a ). Ghosal et al.…”

Section: Discussionmentioning

confidence: 80%

“…The recovery of the lesions in the spleen and bursa of Fabricius in WSR–supplemented infected group indicates an immunomodulatory effect of WSR. W. somnifera has also been reported to provide immunoprotection against E. coli infection in Guinea pigs ( Teixeira et al., 2006 ) and S. gallinarum infection in broilers ( Kumari et al., 2015a ).…”

Section: Discussionmentioning

confidence: 99%

“…W. somnifera has been used as an antioxidant, adaptogen, aphrodisiac, liver tonic, antiinflammatory agent, and astringent agent ( Rastogi and Mehrotra, 1998 ). Ashwagandha root powder (@ 0.5%) supplementation in feed has shown a reduction in the severity of S. gallinarum infection in chicks ( Kumari et al., 2015a ).…”

Section: Introductionmentioning

confidence: 99%

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Ameliorating effect of Withania somnifera root extract in Escherichia coli–infected broilers

et al. 2020

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The present study was undertaken to investigate the effect of aqueous Withania somnifera root ( WSR ) extract in broiler chicks experimentally infected with Escherichia coli O78 @ 10 7 CFU/0.5 ml intraperitoneally. Clinical signs and mortality due to colibacillosis observed in infected chicks were mild and lasted for short duration in WSR extract supplemented group as compared with the nonsupplemented group. A significant increase in serum alanine transaminase, aspartate transaminase, lactate dehydrogenase, and creatine phosphokinase activities and a decrease in total protein and albumin concentrations were observed in the infected groups, though these changes were of lower magnitude in WSR extract supplemented group. A significantly higher activity of oxidative blood parameters such as superoxide dismutase, catalase, glutathione reductase, and glutathione-S-transferase enzymes were noticed in WSR extract supplemented group. The WSR extract supplemented group revealed significantly higher E. coli– specific antibody titer and enhanced lymphocyte proliferation response as compared with the nonsupplemented group. The gross and histopathological lesions of colibacillosis were mild in the WSR extract–supplemented infected group as compared with the nonsupplemented infected group. Withania somnifera root extract supplementation produced 31.48 and 34.38% protection in the gross and histopathological lesions in E. coli infected chicks, respectively. It is concluded that supplementation of 20% WSR extract @ 20 ml/L of water caused a reduction in the severity, mortality, and recovery period of E. coli infection and enhanced the humoral and cellular immune responses suggesting its protective effect on limiting the pathology of E. coli infection in broiler chickens.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ameliorating effect of Withania somnifera root extract in Escherichia coli–infected broilers

et al. 2020

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Withania somnifera as a Phytoherbal Growth Promoter for Broiler Farming – A Review

Oliveira

Attia

Khafaga

et al. 2024

Annals of Animal Science

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Poultry production significantly contributes to bridging the food gap worldwide. Several nations have limited the usage of antibiotic growth promotors due to bacterial resistance to antibiotics and the occurrence of residual antibiotics in the edible tissues of birds. The world is now turning to using natural alternatives to increase poultry production as well as birds’ resistance to diseases. Withania somnifera (WS; family: Solanaceae) is a precious medicinal herb utilized in several countries due to its distinct chemical, medicinal, and physiological properties. This plant has antioxidant, anti-aging, antimicrobial, antitumor, hepatoprotective, cardioprotective, neuroprotective, immunomodulatory, antidiabetic, antistress, and growth-promoting activities. In poultry, the dietary inclusion of WS revealed a promising result in enhancing productive performance, increasing disease resistance, reducing stress effects, and maintaining the bird’s health. Thus, the current review highlights the morphological features, distribution, chemical structure, and pharmacological features of Withania somnifera as a growth promoter herb for farming broiler chickens.

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Promising prospective effects of Withania somnifera on broiler performance and carcass characteristics: A comprehensive review

et al. 2022

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Poultry production contributes markedly to bridging the global food gap. Many nations have limited the use of antibiotics as growth promoters due to increasing bacterial antibiotic tolerance/resistance, as well as the presence of antibiotic residues in edible tissues of the birds. Consequently, the world is turning to use natural alternatives to improve birds' productivity and immunity. Withania somnifera, commonly known as ashwagandha or winter cherry, is abundant in many countries of the world and is considered a potent medicinal herb because of its distinct chemical, medicinal, biological, and physiological properties. This plant exhibits antioxidant, cardioprotective, immunomodulatory, anti-aging, neuroprotective, antidiabetic, antimicrobial, antistress, antitumor, hepatoprotective, and growth-promoting activities. In poultry, dietary inclusion of W. somnifera revealed promising results in improving feed intake, body weight gain, feed efficiency, and feed conversion ratio, as well as reducing mortality, increasing livability, increasing disease resistance, reducing stress impacts, and maintaining health of the birds. This review sheds light on the distribution, chemical structure, and biological effects of W. somnifera and its impacts on poultry productivity, livability, carcass characteristics, meat quality, blood parameters, immune response, and economic efficiency.

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Effect of Ashwagandha (Withania somnifera) supplementation inSalmonella gallinaruminfected broilers

Cited by 3 publications

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Ameliorating effect of Withania somnifera root extract in Escherichia coli–infected broilers

Ameliorating effect of Withania somnifera root extract in Escherichia coli–infected broilers

Withania somnifera as a Phytoherbal Growth Promoter for Broiler Farming – A Review

Promising prospective effects of Withania somnifera on broiler performance and carcass characteristics: A comprehensive review

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