Effect of artemether on hematological parameters of healthy and uninfected adult Wistar rats

Osonuga, IO; Osonuga, OA; Osonuga, A; Onadeko, AA

doi:10.1016/s2221-1691(12)60083-5

Cited by 20 publications

(23 citation statements)

References 16 publications

(20 reference statements)

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“…Several studies reported higher haemoglobin and RBC values (Ola-Davies et al 2014, Vinodini et al 2015, and lower WBC values (Osonuga et al 2012) in rats of Wistar strain than we found. Ashaolu et al (2011) determined similar results to ours for RBC counts in the blood of Wistar rats.…”

Section: Discussioncontrasting

confidence: 56%

Effects of long-term construction noise on health of adult female Wistar rats

Žymantienė¹,

Želvytė²,

Pamparienė³

et al. 2017

Polish Journal of Veterinary Sciences

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The aim of this study was to investigate the influence of long-term building construction noise from refurbishment, which including vibration, on some physiological parameters and histopathological changes of organs of Wistar rats. Twenty 12 month old female rats were divided into two groups: rats group I (n = 10) were exposed to long-term construction noise and rats group II (n = 10) were kept under normal noise level. Study results revealed that long-term construction noise from building refurbishment has an influence on body weight, haematological and some serum biochemical parameters affects caecal microbiota, and causes histopathological changes in the organs of adult female Wistar rats. It was noticed that rats in group I exihibited significantly higher mean values for total protein, albumin and lower values for glucose, AST, ALT, blood urea nitrogen, haematological and caecal microbiota parameters than rats in group II. The most common pathologies were determined in the kidney, liver and lungs. Other observed pathologies were lymphadenopathy, catarrhal inflammation of the intestines, spleen hyperplasia and mammary gland adenofibroma. Single cases were subcutaneous fibroma in the thoracic region, abortus with uterine inflammation and thymus hyperplasia with formation of cysts were found.

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Section: Discussioncontrasting

confidence: 56%

Effects of long-term construction noise on health of adult female Wistar rats

Žymantienė¹,

Želvytė²,

Pamparienė³

et al. 2017

Polish Journal of Veterinary Sciences

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“…This was done according to Osonuga, et al [30] and Aprioku, 2012 [31]. Dosage was calculated with reference to the dose of artemether in the drug combination.…”

Section: Methodsmentioning

confidence: 99%

A dietary strategy for the management of artemether-lumefantrine-induced cardiovascular and renal toxicity

Asiedu-Gyekye

Seidu

N'Guessan

et al. 2016

BMC Complement Altern Med

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BackgroundUnsweetened natural cocoa has antimalarial properties. Unsweetened natural cocoa powder (UNCP), obtained as a result of the removal of cocoa butter from a cocoa bean protects against malaria episodes. Cocoa powder, which is prepared after removal of the cocoa butter, contains about 1.9 % theobromine and 0.21 % caffeine. Concomitant consumption of cocoa and artemether/lumefantrine (A/L) is a common practice in Ghana, West Africa. This study seeks to determine the elemental composition of UNCP and its protective effect on the heart and kidney against (A/L) administration.MethodsEnergy dispersive x-ray fluorescence spectroscopy was used to detect the quality and quantity of the elemental composition in UNCP. Thereafter, 30 nonmalarious male guinea pigs were divided into five groups of six animals each. One group was administered with 75 mg/kg body weight A/L only and another group distilled water (control group). The rest received 300 mg/kg, 900 mg/kg and 1500 mg/kg body weight UNCP for 14 days orally and A/L for the last 3 days (ie day 11 to day 14). Biochemical and histopathological examinations were carried out after euthanisation of the animals.ResultsA total of thirty-eight (38) micro and macro elements were detected with the ED-XRF. Macro elements like sodium (Na), magnesium (Mg), aluminium (Al), phosphorus (P), chlorine (Cl), potassium (K), calcium (Ca), manganese (Mn) and iron (Fe) and micro elements like chromium (Cr), copper (Cu), zinc (Zn), arsenic (As), and lead (Pb) were identified and evaluated. Biochemical analysis revealed increases in HDL levels (p>0.05) while there were decreases in LDL levels (p>0.05), creatine kinase and AST levels (P<0.05) in animals that received UNCP compared to A/L only administered group. Urea levels reduced significantly by 53 % (p<0.05) in group that received 1500 mg/kg UNCP. Histopathological examinations of the heart and kidney buttressed the protective effects of cocoa administration.ConclusionThe percentage of recommended daily allowance of UNCP for chromium is 3750 % for men and 5250 % for women while % RDA for copper corresponds to 103.6 % in both sexes. UNCP proved to possess cardioprotective and renoprotective potential during artemether-lumefantrine administration.

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“…Furthermore, antimalarial agents have been reported to aggravate anaemia in malaria cases. Osonuya et al, [12], reported that artemether can aggravate anaemia when administered in malaria infection. The study reported decrease in red blood cell count, haemoglobin concentration and white blood cell count in albino rats.…”

Section: Discussionmentioning

confidence: 99%

Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in <i>Plasmodium berghi-berghi</i> Infected Mice Treated with <i>Hippocratea africana</i> Root Bark Extract

Ndem¹,

Bassey²,

Effiong³

et al. 2019

JDMP

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The haematopoietic potential of Jatropha tanjorensis leaf extract in Plasmodium berghi-berghi infected mice treated with Hippocratea africana root bark extract was investigated. Thirty (21) adult mice weighing 27-33g were divided into seven (7) groups with three (3) animals in each group. Group 1 served as normal control while Groups 2-7 were parasitized with Plasmodium berghi-berghi and Group 2 was the test control (parasitized and untreated) group. Group 3 was administered 8mg/kg bw of artemether-lumefantrine for 3 days. Group 4 and 5 received daily, 200mg/kg bw and 300mg/kg bw of extracts of Hippocratea africana and Jatropha tanjorensis respectively for 4 days. Group 6 received 8mg/kg bw of artemether-lumefantrine for 3 days followed with 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Group 7 was treated with 200mg/kg bw of Hippocratea africana root extract for 4 days followed by 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Significant anti-plasmodial activity was observed with artemether-lumefantrine and Hippocratea africana root bark extract administration. Plasmodium berghi-berghi infection induced alterations in haematological indices such as decreased RBC count, platelet count, haemoglobin concentration and heamatocrit and increased WBC count. Administration of Jatropha tanjorensis leaf extract showed improved haematological indices particularly in the red blood cell counts and haemoglobin concentration. Jatropha tanjorensis has haematopoietic activity in Plasmodium berghi-berghi infected mice treated Hippocratea africana root bark extract.

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Effect of artemether on hematological parameters of healthy and uninfected adult Wistar rats

Cited by 20 publications

References 16 publications

Effects of long-term construction noise on health of adult female Wistar rats

Effects of long-term construction noise on health of adult female Wistar rats

A dietary strategy for the management of artemether-lumefantrine-induced cardiovascular and renal toxicity

Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in <i>Plasmodium berghi-berghi</i> Infected Mice Treated with <i>Hippocratea africana</i> Root Bark Extract

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Effect of artemether on hematological parameters of healthy and uninfected adult Wistar rats

Cited by 20 publications

References 16 publications

Effects of long-term construction noise on health of adult female Wistar rats

Effects of long-term construction noise on health of adult female Wistar rats

A dietary strategy for the management of artemether-lumefantrine-induced cardiovascular and renal toxicity

Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in &lt;i&gt;Plasmodium berghi-berghi&lt;/i&gt; Infected Mice Treated with &lt;i&gt;Hippocratea africana&lt;/i&gt; Root Bark Extract

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Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in <i>Plasmodium berghi-berghi</i> Infected Mice Treated with <i>Hippocratea africana</i> Root Bark Extract