Effect of aromatic amino acids, pentylenetetrazole and yohimbine on isatin and tribulin activity in rat brain

Bhattacharya, Sayantani Sarkar; Clow, Angela; Przyborowska, A.; Halket, John M.; Glover, Vivette; Sandler, M.

doi:10.1016/0304-3940(91)90429-w

Cited by 41 publications

(21 citation statements)

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“…Tribulin contains two major components; one inhibits MAO-B and has poor a¦nity for BDZ receptors and the other inhibits MAO-A and a¦nity to BDZ receptors (Medvedev et al 1992;Glover and Sandler 1993). Rat brain tribulin activity is increased by anxiogenic agents (Bhattacharya et al 1991a(Bhattacharya et al , 1995b(Bhattacharya et al , 1996Bhattacharya and Mitra 1992) and this increase is reduced by anxiolytic agents (Bhattacharya et al 1987;Bhattacharya and Mitra 1991). Recent reports indicate that both the intensity of drug-induced anxiety and addictive drug withdrawal-induced anxiety in rats are correlated with increases in the MAO-A, but not the MAO-B, inhibitory component of brain tribulin (Bhattacharya et al 1995a(Bhattacharya et al , 1996.…”

Section: Discussionmentioning

confidence: 94%

Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats

1998

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The anxiolytic activity of diazepam (DZP) (0.25-1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various anxiety paradigms, including the open-field exploratory behaviour, elevated plus maze and elevated zero maze behaviours and the social interaction tests. In addition, rat brain tribulin activity was also assessed as a biochemical marker of anxiety. The results indicate that diabetic rats showed significantly more anxiogenic activity in comparison to non-diabetic rats on open-field, elevated plus maze, zero maze and social interaction tests. In diabetic rats, brain tribulin activity (MAO-A inhibitory component) was significantly increased. DZP dose dependently produced anxiolytic activity on the various behavioural parameters in non-diabetic rats. DZP (0.5 and 1 mg/kg) partially reversed the anxiogenic behaviour of STZ diabetic rats in elevated plus maze and zero maze tests. However, in open field behaviour and social interaction tests significant anxiolytic activity was observed only at a higher dose of DZP (1 mg/kg). The findings indicate that STZ-induced diabetic rats exhibited augmented anxiety on various experimental paradigms and that the anxiolytic effect of diazepam was less marked in diabetic rats as compared to their euglycaemic counterparts.

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Section: Discussionmentioning

confidence: 94%

Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats

1998

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“…Given to rabbits (20 mg/kg) PTZ caused a 1.5-fold increase of the isatin content of the brain but no change in the liver (Clow et al 1989). Administration of a similar dose of PTZ (25 mg/kg) to rats caused a similar (, 1.5-fold) increase of the isatin level in the brain (Bhattacharya et al 1991).…”

Section: Effects Of Stressmentioning

confidence: 93%

“…Administration of low doses of isatin to rats or mice induced significant anxiogenic activity in the open field and elevated plus-maze tests (Bhattacharya et al 1991;Bhattacharya and Acharya 1993). The anxiogenic activity of isatin was comparable to that of PTZ Bhattacharya et al 1991 in terms of % entries into the open arms of the maze (Bhattacharya et al 1996a,b).…”

Section: Anxiogenic Effects Of Isatinmentioning

confidence: 98%

Isatin: Role in stress and anxiety

Медведев

Igosheva

Crumeyrolle-Arias

et al. 2005

Stress

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105

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(Indoledione 2,3) isatin is an endogenous indole found both in mammalian brain and peripheral tissues. Isatin concentration in blood can exceed 1 microM and tissue concentrations vary from < 0.1 to 10 microM. Its level in the brain and periphery is increased by stress. Isatin has a wide spectrum of behavioural and metabolic effects. It is anxiogenic at lower doses and sedative at higher doses. Its most potent known in vitro actions are as an antagonist of atrial natriuretic peptide (ANP) function and NO signaling. In this review, we discuss isatin and stress in animal models, the few human studies, and also what it is known to date about the molecular mechanisms of its action. We suggest the possibility that isatin and its analogues may be interesting new pharmacological agents; Isatin antagonists may be anxiolytic, and isatin agonists may activate the HPA axis.

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“…39,40 A very thorough recent study has shown that isatin inhibits both water and food intake in mice at doses of 25 mg/kg. 41 The authors show that it appears to act as a true satiating agent, and suggest that it may be an endogenous compound involved in stress-induced anorexia.…”

Section: Isatinmentioning

confidence: 99%

The psychopharmacology of isatin: a brief review

et al. 1998

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There is a discrepancy in the literature regarding the effect of repeated experience on children's suggestibility. Some researchers have concluded that repeated experience increases children's suggestibility for variable details whereas others have reported no detrimental effect. This study demonstrated that the type of question used to test memory (cued‐recall versus yes/no questions) could account for the different reported conclusions. Children aged 5–6 years took part in an event either once or four times. Three or 21 days later, they were given a suggestive interview about the single/final occurrence of the event during which half of the event details were inaccurately described. When later asked yes/no questions, the children with repeated experience agreed with more of the suggestions than did those in the single‐experience condition, especially at the longer delay. In relation to cued‐recall questions, however, experience did not mediate the number of times that false suggestions from the biasing interview were reported. This latter finding was revealed irrespective of the retention interval. Copyright © 2002 John Wiley & Sons, Ltd.

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Effect of aromatic amino acids, pentylenetetrazole and yohimbine on isatin and tribulin activity in rat brain

Cited by 41 publications

References 10 publications

Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats

Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats

Isatin: Role in stress and anxiety

The psychopharmacology of isatin: a brief review

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