Effect of aqueous extract of Passiflora edulis on biochemical and hematological parameters of Wistar Albino rats

Devaki, K.; Beulah, U.; Guenzet, Akila; Gopalakrishnan, Vishrawas

doi:10.4103/0971-6580.94508

Cited by 28 publications

(11 citation statements)

References 13 publications

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“…All observations point to the nonhematotoxic nature of the extract at the doses used in this study. Other researchers working on varied plant extracts also recorded similar effects (26,27,28,29). However, since changes in hematological parameters occur relatively slowly, the experimental duration may not have been enough to identify any alterations, and such was the findings with Lychnophora trichocarpha (30).…”

Section: Discussionsupporting

confidence: 54%

Antibacterial and toxicological evaluation of the ethanol leaf extract of Anthonotha macrophylla

Essiet

Anwankwo

Akuodor

et al. 2019

J Herbmed Pharmacol

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Introduction: The leaves of Anthonotha macrophylla which are widely used in folkloric medicine in Africa were evaluated for antibacterial activity and its toxicological profile.Methods: Antibacterial activities of the leaves against clinical strains of Staphylococcus aureus, Escherichia coli, Salmonella typhi, Klebsiella pneumonia, Streptococcus pyogenes and Bacillus subtilis were compared with cefoxitin. Toxicological profiles were determined following the administration of 100, 200 and 400 mg/kg of the leaf extract and distilled water, as control, to male Albino rats for 28 days. Biochemical and hematological indices and body weights were determined and the vital organs were examined.Results: The ethanol leaf extract of A. macrophylla demonstrated antibacterial activity against the pathogenic bacteria tested. Toxicological investigation of the leaf extract showed no significant alterations in hematological and biochemical indices, and the vital organs as well. The LD50 in rats was more than 5000 mg/kg.Conclusion: Findings suggest that the ethanol leaf extract of A. macrophylla possess good antimicrobial activity which supports the traditional use of this plant across Africa. The plant is also considered safe following oral exposure after 28 days.

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Section: Discussionsupporting

confidence: 54%

Antibacterial and toxicological evaluation of the ethanol leaf extract of Anthonotha macrophylla

Essiet

Anwankwo

Akuodor

et al. 2019

J Herbmed Pharmacol

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“…The hematological profile of treated rats showed no significant differences with the control group, except that platelets significantly ( P < 0.05) increased by 67.79%; 65.97%, and 70.17%, respectively, at doses 300, 600, and 1200 mg/kg in males and 120.67%; 122.54%, and 126.85%, respectively, at doses 300, 600, and 1200 mg/kg in females. Analysis of blood parameters is relevant to assess the effect of plant extract on the bone narrow [ 18 ]. The increase of leukocytes may indicate strength of the defense mechanism of an organism [ 19 , 20 ] or an unknown subchronic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Acute and sub-chronic oral toxicity assessment of the aqueous extract leaves of Ficus glumosa Del. (Moraceae) in rodents

Ntchapda¹,

Abakar²,

Kom³

et al. 2014

J Intercult Ethnopharmacol

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Background:Ficus glumosa Del (Moraceae), a plant used in traditional medicine in Cameroon, Senegal, and East Africa for the treatment of edema, hemorrhoid, cardiovascular diseases especially hypertension.Aim:The present study evaluated the potential toxicity of the aqueous extract of the leaves of F.glumosa in acute and sub-chronic administration in rodents.Methods:Acute toxicity was evaluated on 3 months old mice of both sexes and weighing 20-30 g. A single dose (2-12 g/kg) of F. glumosa was administered orally to mice. Animal behavior, adverse effects, and mortality were determined for 14 days. In sub-chronic toxicity studied in both sexes of 9 weeks old rats and weighing 100-120 g at the start of the experiment, animals were treated orally with a daily dose of 300, 600 and 1200 mg/kg of the aqueous extract of the leaves of F. glumosa for 6 weeks. The body weight change, food, and water consumption, were determined throughout the experimental period, while the relative organ weights, the hematological and biochemical parameters of blood and urine, as well as the histology of tissues kidney and liver, were recorded at the end of the experiment.Results:For acute treatment, no dose used induced critical behavioral changes or death. In sub-chronic treatment, daily oral administration of F. glumosa at the dose of 300, 600, and 1200 mg/kg resulted in a significant increase in body weight relative to food and water consumption in the last week of treatment. The relative organ weights were not affected by treatment. No hematological changes were observed except the significant increase in platelets. Aspartate aminotransferase, alanine transaminase, alkaline phosphatase, total protein, increased while the total cholesterol, triacylglycerol, conjugated bilirubin, and total bilirubin significantly decreased. Index of renal function showed a decrease of creatinine, urea, uric acid and Na+, Cl− and Ca2+, and inorganic phosphate. The histology of liver and kidney showed no significant alteration of tissue.Conclusion:These observations support the traditional use of F. glumosa in the treatment of hypertension. These results have shown that F. glumosa has a safety margin for therapeutic use.

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“…The control group received 1 ml of physiological saline. They were all placed under observation immediately for 24 h for any behavioral, neurological changes and then mortality for the next 72 h.[ 18 ]…”

Section: Methodsmentioning

confidence: 99%

Evaluation of toxicity effects of asafetida on biochemical, hematological, and histological parameters in male wistar rats

et al. 2015

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Objectives:Asafetida is traditionally used in folklore medicine for the treatment of various ailments. To validate its use in traditional medicine, it is important to evaluate its toxicity in the animal system. Therefore, this study aimed to evaluate the toxicological effects of asafetida in Wistar albino rats.Materials and Methods:Acute toxicity tests were conducted by the oral administration of 250, 500, and 1,000 mg/kg body weight of the animal. In chronic study, animals were administered with various doses of asafetida (25, 50, 100, and 200 mg/kg body weight) for a period of 6 weeks. At end of experiment, the effects of asafetida on hematological, renal, and hepatic markers and histological parameters were analyzed.Results:In acute toxicity study, no mortality was seen up to 72 h of the administration of asafetida. No signs of neurological and behavioral changes were noticed within 24 h. In the chronic study, the asafetida intake has changed the hematological parameters such as red blood cell (RBC), white blood cell (WBC), hematocrit (HCT), and platelets. Aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were significantly increased in treated animals. The plasma level of urea and creatinine were not altered by the administration of asafetida throughout the study. Histopathology study indicates hepatotoxicity, but no signs of prominent pathological changes in kidney.Conclusions:Asafetida did not show any acute toxicity, but chronic administration could have undesirable effects on hepatocytes and hematological factors.

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Effect of aqueous extract of Passiflora edulis on biochemical and hematological parameters of Wistar Albino rats

Cited by 28 publications

References 13 publications

Antibacterial and toxicological evaluation of the ethanol leaf extract of Anthonotha macrophylla

Antibacterial and toxicological evaluation of the ethanol leaf extract of Anthonotha macrophylla

Acute and sub-chronic oral toxicity assessment of the aqueous extract leaves of Ficus glumosa Del. (Moraceae) in rodents

Evaluation of toxicity effects of asafetida on biochemical, hematological, and histological parameters in male wistar rats

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