Effect of aqueous extract of Achillea millefolium on the development of experimental autoimmune encephalomyelitis in C57BL/6 mice

Vazirinejad, Reza; Ayoobi, Fateme; Arababadi, Mohammad Kazemi; Eftekharian, Mohammad Mahdi; Darekordi, Ali; Goudarzvand, Mahdi; Hassanshahi, Gholamhossein; Taghavi, Mohammad Mohsen; Ahmadabadi, Behzad Nasiri; Kennedy, Derek; Shamsizadeh, Ali

doi:10.4103/0253-7613.132168

Cited by 13 publications

(8 citation statements)

References 25 publications

(26 reference statements)

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“…However, the extracts enhanced the activity of the antioxidant proteins reduced GSH and glutathione S-transferase (GST) in the uterus ( Baggio et al, 2016 ). Furthermore, treatment with A. millefollium extracts inhibited autoimmune encephalomyelitis in mice ( Vazirinejad et al, 2014 ).…”

Section: Estrogenic Plants With Antioxidant and Anti-inflammatory Activitymentioning

confidence: 99%

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

et al. 2021

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In mammals, sexual hormones such as estrogens play an essential role in maintaining brain homeostasis and function. Estrogen deficit in the brain induces many undesirable symptoms such as learning and memory impairment, sleep and mood disorders, hot flushes, and fatigue. These symptoms are frequent in women who reached menopausal age or have had ovariectomy and in men and women subjected to anti-estrogen therapy. Hormone replacement therapy alleviates menopause symptoms; however, it can increase cardiovascular and cancer diseases. In the search for therapeutic alternatives, medicinal plants and specific synthetic and natural molecules with estrogenic effects have attracted widespread attention between the public and the scientific community. Various plants have been used for centuries to alleviate menstrual and menopause symptoms, such as Cranberry, Ginger, Hops, Milk Thistle, Red clover, Salvia officinalis, Soy, Black cohosh, Turnera diffusa, Ushuva, and Vitex. This review aims to highlight current evidence about estrogenic medicinal plants and their pharmacological effects on cognitive deficits induced by estrogen deficiency during menopause and aging.

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Section: Estrogenic Plants With Antioxidant and Anti-inflammatory Activitymentioning

confidence: 99%

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

et al. 2021

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“…The composition of the essential oil includes sesquiterpenoids: Achilles, acetylbalquinolide, caryophyllene, proazulene; monoterpenoids: camphor (11), thujol (10), (see above), cineole, pinene, borneol. In addition, alkaloids (the main of which is akhilein), flavonoids, including flavone glycosides apigenin (13) and luteolin (9) (see above) were found in the yarrow herb; tannins (α-phyloquinone), vitamins K, C, A, B; amines: choline, stakhidrin; esters (bornyl acetate, myrtenyl acetate), caryophyllene, organic acids (acetic, formic, malic, isovaleric, aconitic, coffee, chlorogenic), polyins (pontic epoxide, matrixar ester), cyclic alcohol viburnite (20%), menthol, geraniol [290][291][292][293][294]. Yarrow also contains sterols (mainly β-sitosterol, as well as stigmasterol, campesterol, cholesterol, taraxasterol and pseudotaraxasterol), coumarins, the biogenic amine betaine, inulin and other polysaccharides, which contain monosaccharides such as rhamnose, arabinose, xylose, mannose, glucose, galactose, ribose [295].…”

Section: Achillea Millefolium L Aster Family -Asteraceaementioning

confidence: 99%

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Berganayeva¹,

Kudaibergenova²,

Litvinenko³

et al. 2023

Preprint

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According to the eminent scholar, philosopher, and physician Avicenna, "the doctor has three tools: the word, the plant, the knife." The plant kingdom is recognized as humanity's earliest and most ancient healing source, employed for the management and prevention of illnesses. Tracing back through history, the most ancient documented proof of plants' utilization in medicine dates back to a Sumerian clay slab discovered in Nagpur roughly 5000 years ago. This artifact included a compilation of twelve medicinal recipes that involved over 250 diverse plant species. Sumerian healers extracted powders and infusions from plant roots and stems, while also crediting healing properties to pears and figs. Additionally, they utilized dried and ground young shoots of willow and plum trees, pine and fir needles as a component in compresses and poultices. Often, powders from animal and mineral sources were blended with those extracted from dried and crushed plants. Notably, in addition to water, wine and beer served as solvents. Thus, at least 80 centuries ago, people utilized the most uncomplicated medicinal plant-based preparations for treatment [1]. The "Pen T'Sao," an ancient Chinese text on roots and herbs, authored by Emperor Shen Nung approximately 2500 BC, contains descriptions of 900 medicaments (comprising dried components of medicinal plants). Several of these substances are still in use today, including Rhei rhisoma, camphor, Theae folium, Podophyllum, great yellow gentian, ginseng, datura, cinnamon bark, and ephedra [2]. Regarding Kazakh folk medicine, an area that has yet to be fully explicated and substantiated, it can be stated that the traditional medicinal knowledge of the Kazakh people transcends the mere treatment of ailments and rests on robust theoretical underpinnings. Oteiboydak Tleukabyluly (1388-1478), an astute healer and prominent figure in Kazakh folk medicine during the 15th century, comprehensively explicated the secrets of the healing art in his medical and ethnographic work "Medical Narrative," which he composed between 1466 and 1473 at the behest of az-Zhanibek Khan, who held him in high esteem as a great healer. This medical encyclopedia delineates the functions of various organs of the human body and provides a catalogue of the primary diseases associated with them. Furthermore, it includes a meticulous description of the methods used in traditional medicine at present, such as setting bones, listening to the pulse, and incantations. Through practical experimentation and experimentation conducted in the steppe laboratory, the healer formulated a total of 1,108 different medicinal compounds, of which 858 were derived from medicinal plants, 318 were extracted from animal organs, and roughly 60 were sourced from metals. The moniker "Teacher without a teacher" was bestowed on Oteiboydak Tleukabylov, who discovered methods for treating 1,050 different diseases [3]. At present, the employment of phytotherapy has gained widespread acceptance on a global scale. According to the World Health Organization's (WHO) global review of national policies concerning traditional, complementary, and alternative medicine, as well as the regulation of herbal medicines, there is an evident growth in the European and Asian market for herbal medicines [4]. Kazakhstan boasts a natural flora of over 6,000 plant species [5]. The exact number of medicinal plant species present in Kazakhstan remains uncertain, as the list continues to expand annually. More than 150 plant species have been employed in both official and folk medicine for various ailments. This review focuses on a selection of medicinal plants growing within the territory of the Republic of Kazakhstan that have traditionally been used to alleviate skin diseases. In conducting this study (2010-2023), emphasis was placed on the plants' phytochemical composition, with a particular focus on the principal components responsible for their therapeutic effects against inflammatory skin conditions such as dermatitis, atopic dermatitis, and eczema.

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“…By virtue of its composition [ 48 , 49 , 50 , 51 ], Tr14 also able to actively promote the expression of the following Specialized pro-resolving mediators (SPMs): (i) lipoxin A4 (LXA4); (ii) Resolvin D2-D5 (RvD2/D5); (iii) Neuroprotectin D1 (NPD1) , accessed on 1 February 2021 ( Figure 5 ).…”

Section: Low Dose Drugs For the Management Of Acute And Chronic Inflammationmentioning

confidence: 99%

Regulation of Inflammatory Reaction in Health and Disease

Fioranelli

Flavin²,

Linda³

2021

IJMS

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Inflammation is a key mechanism for the clearance of infective agents and other inflammatory triggers and is pivotal for the repairing processes of the affected tissues. Inflammation is a multistep process driven by a great number of mediators which regulate specific aspects of the inflammatory response, in agreement with a well-defined chronobiological program. A great number of inflammation-related diseases show a deeply altered immune chronobiology (e.g., COVID-19-related cytokines storm). This aspect highlights the need for a deeper understanding of the inflammatory phenomenon. It is fundamental to study inflammation as a multilevel phenomenon. Of particular interest is the low-grade chronic inflammation, which is an etiological factor of many chronic diseases. Nowadays, the therapeutic approach to low grade chronic inflammation is one of the great challenges of traditional pharmacology. Currently, no drugs specifically designed for the treatment of chronic inflammatory forms are available. Today, bioregulatory systems medicine (BrSM) and low dose medicine (LDM), two pharmacological paradigms grounded in systems medicine, potentially represent new tools for the treatment of inflammation-related diseases. Scientific research has assessed the effectiveness and safety of both these therapeutic approaches, in particular for the management of chronic inflammatory conditions and chronic immunological dysregulations.

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Effect of aqueous extract of Achillea millefolium on the development of experimental autoimmune encephalomyelitis in C57BL/6 mice

Cited by 13 publications

References 25 publications

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Regulation of Inflammatory Reaction in Health and Disease

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