Effect of application time and concentration of silver diamine fluoride on the enamel remineralization

Abstract

Background Silver diamine fluoride has attracted attention because of its clinical success in arresting dental caries. Thus, the aim of this study was to evaluate the effect of different application times and concentrations of silver diamine fluoride (SDF) on deciduous tooth enamel remineralization. Material and Methods Blocks of deciduous tooth enamel were categorized into six groups of 11 each: 2 control groups: intact enamel, and demineralized enamel; 38% SDF and 30% SDF which were subdivided according to application times (1 and 3 min). The microhardness of samples was determined, and all groups except the intact enamel group were subjected to pH cycling to produce initial carious lesions. The 38% and 30% SDF solutions were applied to the enamel for 1 or 3 min. After pH cycling and SDF treatments, the microhardness was again determined. Samples were sectioned to evaluate the cross-sectional microhardness. Furthermore, internal porosity of the samples was examined using micro-CT. Data were statistically analyzed by analysis of variance followed by Tukey’s test, and linear regression analyses were performed. Results There was no difference in enamel remineralization based on surface and cross-sectional microhardness. The 30% SDF solution applied for 3 min promoted significantly less pores than the other groups. Conclusions The 1-min application time promoted enamel remineralization regardless of the SDF concentration (30% or 38%). Key words: Cariostatic agents, dental caries, primary tooth, tooth remineralization.

Remineralization of early enamel lesions with a novel prepared tricalcium silicate paste

“…According to published evidenc SDF-KI was incroporated in the current study as a representative of fluoride-based remineralizing products. Punhagui et al 9 concluded that the application of 38% SDF or even 30% SDF has a significant remineralization effect on the enamel surface and CSMH. Punhagui et al 9 conducted the enamel CSMH test at 10, 20, 50, 70, and 90 µm on deciduous enamel.…”

“…Punhagui et al 9 concluded that the application of 38% SDF or even 30% SDF has a significant remineralization effect on the enamel surface and CSMH. Punhagui et al 9 conducted the enamel CSMH test at 10, 20, 50, 70, and 90 µm on deciduous enamel. However, the study is in line with Punhagui et al, citing that Punhagui et al’s study may be considered weak evidence.…”

“…The carries arrest ability of SDF has shown marked superiority over other fluoride-based products, such as sodium fluoride and stannous fluoride 7 , 8 . In addition to its superior role in caries prevention and arrest, several laboratory studies have also assessed its remineralization power 9 , 10 .…”

Efficacy of 30% and 38% Silver Diamine Fluoride in Arresting Caries Lesions After Different Application Times: An in Vitro Study

“…In contrast, a recent in vitro study that also used micro-CT to investigate whether SDF at concentrations of 30% and 38% applied for 1 and 3 minutes would be able to remineralize blocks of dental enamel from deciduous teeth the authors observed that SDF 30% promoted greater enamel remineralization compared to other times and concentrations [25]. However, in the mentioned study, the samples were not subjected to a cariogenic challenge after treatment with SDF, and the way of remineralization evaluation was the quantification of the internal porosity of enamel (the fewer pores, the greater the remineralization).…”

A Review of the Protocol of SDF Therapy for Arresting Caries

“…17 , 23 However, a laboratory study found no difference in enamel remineralisation between 60 seconds and 180 seconds of SDF application. 24 In addition, no literature investigated whether the 60-second application is the optimum application time. A lack of cooperation often compromises treatment or renders SDF treatment impossible or ineffective.…”