Effect of Antituberculous Drugs on Serum Uric Acid and Urine Uric Acid Excretion

Louthrenoo, Worawit; Hongsongkiat, Sith; Kasitanon, Nuntana; Wangkaew, Suparaporn; Jatuworapruk, Kanon

doi:10.1097/rhu.0000000000000297

Cited by 22 publications

(17 citation statements)

References 22 publications

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“…The level of SUA is closely related to the renal excretion of uric acid. Besides, pathological change, diet, gene mutation or medicine effects may affect the excretion of uric acid [13][14][15][16]. A number of studies have shown that reduction of uric acid excretion is harmful to various systems [17], while some recent studies have demonstrated that increased uric acid excretion may be one of the causes of acute and chronic kidney disease as well.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of different urinary uric acid indicators in patients with chronic kidney disease

et al. 2020

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Background: Mounting studies have shown that hyperuricemia is related to kidney diseases through multiple ways. However, the application of urinary uric acid indicators in patients with reduced renal function is not clear. In this study, we aim to determine the effects of renal function on various indicators reflecting uric acid levels in patients with chronic kidney disease (CKD). Methods: Anthropometric and biochemical examinations were performed in 625 patients with CKD recruited from Dept of Nephrology of Huadong hospital affiliated to Fudan University. Multiple regression analyses were used to study correlations of the estimated glomerular filtration rate (eGFR) with serum uric acid (SUA) and renal handling of uric acid. For further study, smooth curve plots and threshold effect analyses were applied to clarify associations between renal function and uric acid levels. Results: The nonlinear relationships were observed between eGFR and urinary uric acid indicators. The obvious inflection points were observed in smooth curve fitting of eGFR and fractional excretion of uric acid (FEur), excretion of uric acid per volume of glomerular filtration (EurGF). In subsequent analyses where levels of eGFR< 15 mL/min/1.73m 2 were dichotomized (CKD5a/CKD5b), patients in the CKD5a showed higher levels of FEur and EurGF while lower levels of urinary uric acid excretion (UUA), clearance of uric acid (Cur) and glomerular filtration load of uric acid (FLur) compared with CKD5b group (all P < 0.05). And there was no significant difference of SUA levels between two groups. On the other hand, when eGFR< 109.9 ml/min/1.73 m 2 and 89.1 ml/min/1.73 m 2 , the resultant curves exhibited approximately linear associations of eGFR with Cur and FLur respectively. Conclusion: FEur and EurGF showed significantly compensatory increases with decreased renal function. And extrarenal uric acid excretion may play a compensatory role in patients with severe renal impairment to maintain SUA levels. Moreover, Cur and FLur may be more reliable indicators of classification for hyperuricemia in CKD patients.

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Section: Discussionmentioning

confidence: 99%

Efficacy of different urinary uric acid indicators in patients with chronic kidney disease

et al. 2020

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“…As is stated before, anti‐TB treatment can result in liver injury through four mechanisms 3 . As for uric acid levels, all patients enrolled were treated with INH, RIF, PZA, and EMB, in which INH, PZA, EMB, and their metabolites could compete with uric acid for the organic acid excretion pathway, reducing the excretion of uric acid, thus causing the increase of uric acid y 67 . In this study, a statistical significance on the relationship between mutant homozygote AA and total protein was found.…”

Section: Discussionmentioning

confidence: 99%

Collagen type XVIII alpha 1 chain (COL18A1) variants affect the risk of anti‐tuberculosis drug‐induced hepatotoxicity: A prospective study

Jiao

Wang

et al. 2020

Clinical Laboratory Analysis

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Background The role of collagen type XVIII alpha 1 chain (COL18A1) in anti‐tuberculosis drug‐induced hepatotoxicity (ATDH) has not been reported. This study aimed to explore the association between of COL18A1 variants and ATDH susceptibility. Methods A total of 746 patients were enrolled in our study from December 2016 to April 2018, and all subjects in the study signed an informed consent form. The custom‐by‐design 2x48‐Plex SNPscanTM kit was used to genotype all selected 11 SNPs. Categorical variables were compared by chi‐square (χ2) or Fisher's exact test, while continuous variables were compared by Mann‐Whitney's U test. Plink was utilized to analyze allelic and genotypic frequencies, and genetic models. Multivariate logistic regression analyses were used to adjust potential factors. The odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were also calculated. Results Among patients with successfully genotyping, there were 114 cases and 612 controls. The mutant A allele of rs12483377 conferred the decreased risk of ATDH (OR = 0.13, 95%CI: 0.02–0.98, P = 0.020), and this significance still existed after adjusting age and gender (P = 0.024). The mutant homozygote AA genotype of rs12483377 was associated with decreased total protein levels (P = 0.018). Conclusion Our study first revealed that the A allele of COL18A1 rs12483377 was associated with the decreased risk of ATDH in the Western Chinese Han population, providing new perspective for the molecular prediction, precise diagnosis, and individual treatment of ATDH.

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“…These are considered as committed markers of nephritic injury and suggest the loss of a major part of kidney function . These anti‐TB drugs also lead to elevation of cholesterol, which can be due to deposition of fat in the liver, latter develops either due to lipids oversupply or interference with lipid accumulation mechanisms . There is a strong link between hypercholesterolaemia and increased free radical production.…”

Section: Discussionmentioning

confidence: 99%

“…24 These anti-TB drugs also lead to elevation of cholesterol, which can be due to deposition of fat in the liver, latter develops either due to lipids oversupply or interference with lipid accumulation mechanisms. 25,26 There is a strong link between hypercholesterolaemia and increased free radical production. During oxidative stress, ROS are produced, which react with lipoproteins to generate their oxidation states, consequently cellular absorption of lipids from the blood is decreased.…”

Section: Discussionmentioning

confidence: 99%

Expression profile of markers of oxidative stress, injury and apoptosis in anti‐tuberculosis drugs induced nephrotoxicity

et al. 2019

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Effect of Antituberculous Drugs on Serum Uric Acid and Urine Uric Acid Excretion

Abstract: The hyperuricemic effect of pyrazinamide and ethambutol was due primarily to a decrease in UACl, which was reversible, and had no negative effect on the renal function. Arthralgia was uncommon and required no specific treatment.

Cited by 22 publications

References 22 publications

Efficacy of different urinary uric acid indicators in patients with chronic kidney disease

Efficacy of different urinary uric acid indicators in patients with chronic kidney disease

Collagen type XVIII alpha 1 chain (COL18A1) variants affect the risk of anti‐tuberculosis drug‐induced hepatotoxicity: A prospective study

Expression profile of markers of oxidative stress, injury and apoptosis in anti‐tuberculosis drugs induced nephrotoxicity

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