Efficacy of different urinary uric acid indicators in patients with chronic kidney disease

Guan, Haochen; Zheng, Yuqi; Zhou, Xun; Xu, Ying; Fu, Chensheng; Xiao, Jing; Ye, Zhibin

doi:10.1186/s12882-020-01953-z

Cited by 15 publications

(15 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alterations in parameters such as blood urea, creatinine, uric acid, and serum electrolytes from normal ranges may reflect renal problems and nephron dysfunction [ 25 , 33 , 34 ]. Compared to the control animals, ACP at tested doses caused no significant change in creatinine, urea, and uric acid levels.…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition and Chronic Toxicity of Disc-Cultured Antrodia cinnamomea Fruiting Bodies

Liu

Hsu

et al. 2022

Toxics

View full text Add to dashboard Cite

Antrodia cinnamomea (AC) is a popular fungus for use as folk medicine in health maintenance and disease prevention and treatment. Disc culture is a novel technique for producing AC fruiting bodies. This study aimed to investigate the bioactive components and toxicological properties of disc-cultured AC fruiting body powders (ACP) in rats. The HPLC technique was used to quantify the composition of bioactive triterpenoids in ACP. Toxicological properties were evaluated on male and female Sprague-Dawley rats receiving ACP orally at 200, 600, and 1000 mg/kg body weight for 90 days; the control group received only distilled water. The results show that ACP contained seven important AC index compounds, namely antcins A, B, C, K, and H, dehydrosulphurenic acid, and dehydroeburicoic acid. At the tested doses, oral ACP administration for 90 days caused no mortality, adverse effects on general health, body and organ weights, and food intake. Furthermore, no significant variations were observed in hematological and biochemical parameters among either sex of ACP-treated and control animals. An histopathological examination of vital organs showed no significant structural changes in organs, even in high-dose ACP-treated animals. This study indicated that ACP contained the major bioactive triterpenoids of AC fruiting bodies, and its no-observed-adverse-effect level (NOAEL) was 1000 mg/kg/day, about 20 times the recommended daily intake.

show abstract

Section: Discussionmentioning

confidence: 99%

Chemical Composition and Chronic Toxicity of Disc-Cultured Antrodia cinnamomea Fruiting Bodies

Liu

Hsu

et al. 2022

Toxics

View full text Add to dashboard Cite

show abstract

“…2,3 As an important indicator of kidney function, the estimated glomerular filtration rate (eGFR) should be paid close attention for early detection of renal function decline. 4,5 In normal physiology, eGFR usually decreases with age by 0.5-1.0 mL/min/1.73 m 2 per year. 6,7 Whereas rapid eGFR decline, a rapid progressive decline in GFR, is generally recognized as an early marker of progressive kidney disease, and has been identified to be associated with cardiovascular disease and all-cause mortality.…”

Section: Introductionmentioning

confidence: 99%

“…As an important indicator of kidney function, the estimated glomerular filtration rate (eGFR) should be paid close attention for early detection of renal function decline 4,5 . In normal physiology, eGFR usually decreases with age by 0.5–1.0 mL/min/1.73 m 2 per year 6,7 .…”

Section: Introductionmentioning

confidence: 99%

A follow‐up study to explore factors associated with rapid kidney function decline and new‐onset kidney disease among Chinese elderly population

Xiong

Zheng

Luo

et al. 2022

Geriatrics Gerontology Int

View full text Add to dashboard Cite

To explore potential factors associated with rapid kidney function decline and new-onset kidney disease among a Chinese elderly population, and to examine the relationships between baseline serum uric acid (SUA), longitudinal change in SUA and rapid estimated glomerular filtration rate (eGFR) decline over 5 years for this Chinese elderly population.Methods: A 5-year follow-up study was conducted from 2016 to 2020 in Xiamen City, China; and 2436 elderly people with normal kidney function at baseline was included. The multivariable logistic regressions were used to explore risk factors for rapid eGFR decline and new-onset kidney disease. Results:The median age of subjects was 65 years, and 38.5% were men. These elderly people experienced a median 5-year decrease in eGFR of 14.50 mL/min/1.73 m 2 , and 11.2% of them had developed new-onset kidney disease after 5-year follow-up. Participants with elevated SUA change from the normal group to the hyperuricemia group witnessed the highest decrease of eGFR after a 5-year follow-up than other groups. Multivariate analysis found advanced age, female, elevated baseline SUA, elevated SUA change, hypertension and triglyceride-glucose index were risk factors for rapid eGFR decline and new-onset kidney disease. Conclusion:The Chinese elderly population was more likely to encounter rapid renal function decline and new-onset kidney disease. A regular test for kidney disease was strongly recommended for these elderly people who were female, with advanced age, with elevated baseline SUA and elevated SUA change; and had high levels of insulin resistance, and blood pressure. The derived findings can offer significant evidence for targeted prevention for the Chinese elderly population.

show abstract

“…urate transporter 1 (URAT1), and organic anion transporter 4 (OAT4)), and with approximately 10% excreted 11 . As kidney function declines, uric acid is retained 12 . However, it has been demonstrated that renal impairment is accompanied by a significant compensatory increase in the fractional excretion of uric acid (FeUA) and in the excretion of uric acid per volume of glomerular filtration 12 .…”

Section: Introductionmentioning

confidence: 99%

“…As kidney function declines, uric acid is retained 12 . However, it has been demonstrated that renal impairment is accompanied by a significant compensatory increase in the fractional excretion of uric acid (FeUA) and in the excretion of uric acid per volume of glomerular filtration 12 . Furthermore, extra-renal uric acid excretion also increases as a compensatory response to reduced kidney excretion of uric acid 13 .…”

Section: Introductionmentioning

confidence: 99%

Hyperuricemia and chronic kidney disease: to treat or not to treat

et al. 2021

View full text Add to dashboard Cite

Hyperuricemia is common in chronic kidney disease (CKD) and may be present in 50% of patients presenting for dialysis. Hyperuricemia can be secondary to impaired glomerular filtration rate (GFR) that occurs in CKD. However, hyperuricemia can also precede the development of kidney disease and predict incident CKD. Experimental studies of hyperuricemic models have found that both soluble and crystalline uric acid can cause significant kidney damage, characterized by ischemia, tubulointerstitial fibrosis, and inflammation. However, most Mendelian randomization studies failed to demonstrate a causal relationship between uric acid and CKD, and clinical trials have had variable results. Here we suggest potential explanations for the negative clinical and genetic findings, including the role of crystalline uric acid, intracellular uric acid, and xanthine oxidase activity in uric acid-mediated kidney injury. We propose future clinical trials as well as an algorithm for treatment of hyperuricemia in patients with CKD.

show abstract

Efficacy of different urinary uric acid indicators in patients with chronic kidney disease

Cited by 15 publications

References 31 publications

Chemical Composition and Chronic Toxicity of Disc-Cultured Antrodia cinnamomea Fruiting Bodies

Chemical Composition and Chronic Toxicity of Disc-Cultured Antrodia cinnamomea Fruiting Bodies

A follow‐up study to explore factors associated with rapid kidney function decline and new‐onset kidney disease among Chinese elderly population

Hyperuricemia and chronic kidney disease: to treat or not to treat

Contact Info

Product

Resources

About