Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats

Mizui, Takuji; Sato, Hatsuo; Hirose, Fumiaki; Doteuchi, Masami

doi:10.1016/0024-3205(87)90456-5

Cited by 112 publications

(71 citation statements)

References 35 publications

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“…ROS, including superoxide anions, hydrogen peroxide, hydroxyl radicals, and lipid peroxidation are important in the pathogenesis of gastric mucosal injury (4,7,37). MDA is the final product of lipid peroxidation and is used as an estimate of lipid peroxidation levels (38).…”

Section: Discussionmentioning

confidence: 99%

Syzygium aromaticum water extract attenuates ethanol-induced gastric injury through antioxidant effects in rats

Jin

Lee

Shin

et al. 2016

Molecular Medicine Reports

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Abstract. The aim of the present study was to investigate whether Syzygium aromaticum water extract (SAWE) has a protective effect against ethanol-induced gastric injury in rats. Acute gastric injury was induced via intragastric administration of absolute ethanol at a dose of 5 ml/kg. SAWE (250 or 500 mg/kg/day) or cimetidine (100 mg/kg/day), which was used as a positive control, were administered to the rats 2 h prior to ethanol administration for 3 days. All rats were sacrificed 24 h following the final ethanol administration. To examine whether SAWE has a gastroprotective effect, assays were performed to assess the contents of malondialdehyde (MDA) and glutathione (GSH), the activities of catalase, glutathione-S-transferase and superoxide dismutase, and an immune-linked immunosorbent assay was performed for prostaglandin E 2 (PGE 2 ) production in gastric tissues by hematoxylin and eosin and periodic acid-Schiff staining. Histological assessment of the gastric wall was performed. Compared with ethanol treatment alone, treatment with SAWE at a dose of 250 mg/kg/day significantly decreased the gastric MDA content and increased the GSH content, catalase activity, and production of gastric PGE 2 . Histological assessment showed that SAWE attenuated inflammatory cell infiltration and the loss of epithelial cells. These findings suggested that SAWE protected against ethanol-induced gastric mucosal injury in the rats. These effects appeared to be associated with antioxidant activity, activation of the production of PGE 2 , suppression of inflammatory cell infiltration and loss of epithelial cells in the gastric mucosa. Collectively, SAWE may be beneficial in the prevention of gastric disease associated to oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Syzygium aromaticum water extract attenuates ethanol-induced gastric injury through antioxidant effects in rats

Jin

Lee

Shin

et al. 2016

Molecular Medicine Reports

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“…Occurrence of these ulcers, which is predominant in the glandular part of the stomach, was reported to stimulate the formation of ROS (Mizui et al, 1987), resulting in damage to rat gastric mucosa (Peskar et al, 1986). EtOH also destroys the protective factors of the mucosa, such as the mucus barrier.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of standardized extract ofCleome viscosaagainst experimentally induced gastric lesions in the rat

Gupta

Rao

Sharma

2013

Pharmaceutical Biology

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Context: Cleome viscosa Linn. (Capparidaceae) is used traditionally in the Indian system of medicine as a carminative, anthelmintic, and diuretic, and used for healing wounds, ulcers and diarrhea. Objective: A 70% ethanol (EtOH) extract of the aerial parts of Cleome viscosa extract (CVE) was investigated for gastroprotective activity in different gastric ulcer models in order to validate ethnobotanical claims regarding the plant use in ulcers. Materials and methods: CVE (100, 200 and 400 mg/kg body weight) was administered orally, twice daily for 5 d, for prevention from EtOH, pylorus ligation (PL) and cold restraint stress (CRS)-induced ulcers in rats. Estimation of H þ K þ ATPase activity and gastric wall mucous were performed in EtOH-induced ulcer, antioxidant enzyme activities in supernatant mitochondrial fraction of CRS-induced ulcer, and gastric secretion parameters were estimated in PL-induced ulcer model Results: CVE showed significant (p50.01) dose-dependent inhibition of lesion index in EtOH 15.93-42.30%, PL 26.34-59.28% and CRS 22.58-54.03%, respectively. CVE prevents the oxidative damage of gastric mucosa by blocking lipid peroxidation and by a significant (p50.001) decrease in superoxide dismutase, and an increase in catalase activity. A significant (p50.01) decrease occurred in the level of H þ K þ ATPase, volume of gastric juice and total acidity. Simultaneously, the level of gastric wall mucus and pH were increased significantly (p50.05). High performance thin layer chromatography analysis showed the presence of quercetin and gallic acid (0.3% and 0.25% w/w, respectively) in CVE. Conclusions: Results of our study showed that C. viscosa possesses significant gastroprotective activity, probably due to free radical scavenging activity, and validates the folklore claim.

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“…SOD and CAT enzymes are highly specific in their catalytic mode of actions and it 5 decreases the gastric mucosal damaging effect of aspirin (26). Although the increase in catalase is necessary for effective antioxidant activity, the changes in CAT levels were significant (27). Hence the 6. antioxidant activity of (SBE) may be one of the important defensive factors involved in its ulceroprotective effect.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant effect of methanolic extract ofSolanum nigrum berries on aspirin induced gastric mucosal injury

Jainu

Devi

2004

Indian J Clin Biochem

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The antiulcerogenic effects of the methanolic extract of Solanum nigrum berries (SBE) on aspirin induced ulceration in rats with respect to antioxidant status in the gastric mucosa have been investigated. Oxygen free radicals are considered to be important factors in the pathogenesis of gastric ulcer. The level of lipid peroxides, which were elevated highly in rats with acute gastric mucosal injury was taken as an index of oxidative stress .The activities of antioxidant defense enzymes were also decreased considerably by oral gastric adminisb'alJon of aspirin. The decreased levels of antioxidant enzymes and increased mucosal injury were altered to near normal status upon pretreatment with (SBE) when compared to the ulcer induced rats. The results indicate that (SBE) may exert its gastroprotective effect by a free radical scavenging action. Our observations suggest that (SBE) may have considerable therapeutic potential in the treabnent of gastric diseases.

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Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats

Cited by 112 publications

References 35 publications

Syzygium aromaticum water extract attenuates ethanol-induced gastric injury through antioxidant effects in rats

Syzygium aromaticum water extract attenuates ethanol-induced gastric injury through antioxidant effects in rats

Protective effect of standardized extract ofCleome viscosaagainst experimentally induced gastric lesions in the rat

Antioxidant effect of methanolic extract ofSolanum nigrum berries on aspirin induced gastric mucosal injury

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