Effect of Antioxidants on Outcome of Testicular Torsion in Rats of Different Ages

Abstract

Testicular morphology was altered less in rats when torsion occurred earlier in life, that is during puberty. Treatment with antioxidants improved contralateral spermatozoid production and some fertility parameters. Each antioxidant also prevented testicular morphology alterations after testicular torsion. Prepubertal rats benefited most from antioxidant treatment.

Oxytocin in The Prevention of Injury Due to Testicular Torsion/Detorsion in Rats

“…[42] Positive effects of antioxidants on oxidative stress parameters and different tissues in oxidative stress conditions, such as atherosclerosis, hypertension, [43] type 2 diabetes mellitus, [44] ulcerative colitis, [45] and testicular torsion, have been shown. In this context, for preventing harmful effects of oxidative stress, many antioxidant agents, such as vitamin E, melatonin, retinol, β-carotene, omega-3, resveratrol, allopurinol, melatonin, Nacetylcysteine, zinc aspartate, and caffeic acid phenethyl ester, vitamin C, coenzyme Q10, and acetylcysteine have been used with different success rates.…”

The relationship between renal warm ischemia time and glomerular loss. An experimental study in a pig model

“…The kidneys were harvested, weighed, and their volumes measured by the Scherle's method 17,18 ; then, the organs were fixed by immersion in 4% buffered formaldehyde according to our laboratory routine. Samples were collected from the cortical region of these 64 kidneys and were processed by routine histological methods for stereological analysis.…”

The Effects of Local and Systemic Growth Hormone Treatment on Germ Cell Population and Fertility in an Experimental Unilateral Testicular Torsion and Orchiectomy Model

“…Potency or the ability of the male rat to mate was calculated as the ratio of female rats mated to the number of female rats exposed for mating  100. 13,24 The fertility index was calculated as the ratio of the number of implantation sites to the number of corpora lutea. 13,24 Fecundity was calculated as the ratio of the number of male rats responsible for at least 1 viable fetus to the total number of male rats exposed for mating  100.…”

“…13,24 The fertility index was calculated as the ratio of the number of implantation sites to the number of corpora lutea. 13,24 Fecundity was calculated as the ratio of the number of male rats responsible for at least 1 viable fetus to the total number of male rats exposed for mating  100. 13,24 Statistical Analysis Data are expressed as the mean AE SEM.…”

“…2,13e15 In these studies the preventive treatments were applied before or shortly after unilateral testicular torsion was done. 2,13,14 However, late hospital admission and delayed diagnosis are common in these patients and it is difficult to provide any preventive treatment in clinical settings. The number and function of survived germ cells are important in these patients when the contralateral testis is also affected.…”