Effect of Antioxidant Vitamins C and E Supplementation on its Plasma Levels and on Lipid Profile in Pulmonary Tuberculosis Patients26

Abstract

Problem statement: Patients with active pulmonary Tuberculosis (TB) are malnourished as indicated by reductions in lean mass, anthropometric indices and micronutrient status. Supplementation with vitamins may prove to be beneficial. Limited information is available on the supplementation of vitamin C and E in pulmonary TB patients. Hence, the present study was undertaken to address the question whether any benefit could be demonstrated with supplementation of antioxidant vitamins C and E and in combination in pulmonary TB patients. Approach: A five arm study was carried out for a period of 6 months in which the normal healthy volunteers served as control group and the sputum positive category I pulmonary TB patients served as the treatment group. Three out of the four patient groups received the antioxidant vitamin supplementation of either vitamin C, vitamin E or in combination along with ATT, whereas fourth group received ATT alone. Plasma concentrations of vitamin C and E were analyzed pre, during and post Anti-Tuberculosis Therapy (ATT) to establish the role of oral supplementation of these vitamins. Sputum culture was also done at all the three times points for Mycobacterium tuberculosis. To study the possible interaction and influence of the supplemented vitamins on LDL-C and HDL-C and other lipid parameters a lipid profile was carried out. Results: (1) All the patients in the treatment groups turned sputum at the end of 2 months of treatment. (2) There was a significant improvement in the body weights of the patients upon supplementation with antioxidant vitamins. (3) There was a significant increase in the of plasma ascorbic acid and α-tocopherol levels after 6 months of treatment in the vitamin C and vitamin E supplemented groups. (4) The HDL-C levels increased significantly in the antioxidant vitamin supplemented groups. (5) Lower levels of LDL-C were observed in the antioxidant vitamin supplemented groups when compared to the un-supplemented group. Conclusion: The plasma concentrations of ascorbic acid and α-tocopherol increased significantly after their dietary supplementation. The increase could also be due to the synergy exhibited by both the vitamins. Vitamin C and vitamin E supplementation influenced the lipid profile by increasing the serum HDL-C, improving the total cholesterol levels and decreasing the LDL-C concentration in the antioxidant vitamin supplemented groups.

Underweight increases the risk of pulmonary tuberculosis in adult

“…The low antioxidant level is caused by inadequate intake and increased free radicals in the phagocytosis of Mycobacterium. These results agree with the study by Madhavi et al, (20) who found that tuberculosis patients receiving high doses of vitamin C for 2 weeks showed increased total antioxidants. These results are supported by a study in Bandung, reporting that administration of vitamin C is of benefit for increasing the antioxidant level in patients with pulmonary tuberculosis.…”

Vitamin B12 Status in Males and Females of different Age Groups

“…These results suggest that Jordanians eat adequate animal products to increase the daily intake of vitamin B12. However, it is possible that there may be other important factors like geographical variation (Bindra et al, 1987), different life style (Papandreou et al, 2006), racial and ethnic differences (Bindra et al, 1987), genetic factors (Feng et al, 2009;Jang et al, 2002), normal absorption of vitamin B12 (Roddie and Davis, 2009), the storage period of fresh juices (Chandrasekaram et al, 2009), adequate daily intake of vitamin B12 and folic acid (Fenech, 2001), the plasma level of vitamin E and vitamin C (Adewolu and Aro, 2009;Madhavi et al, 2009) as well as the accurate cooking of vegetables (Rowe et al, 2009) and folic acid supplementation of grain products (Roddie and Davis, 2009), that were not taken in consideration in this study that could influence the vitamin B12 status of subjects.…”

Vitamin E and Beta Carotene Composition in Four Different Vegetable Oils

“…By its free radical quenching activity, it breaks chain propagation and thus terminates free radical attack at an early stage and the methyl groups of tocopherol interact with the cis double bounds of the fatty acids to form a stable complex in membrane phospholipids. Supplementation with vitamin E in humans decreases the susceptibility of LDL to oxidation in vivo (Madhavi et al, 2009). Some studies have shown that vitamin E has beneficial effects on plasma lipids (Park and Choi, 2002;Gazis et al, 1999;Maria, 2001;Jain and Palmer, 1996;Halliwell, 2002).…”