Effect of antioxidant supplements on sperm parameters in infertile male smokers: a single-blinded clinical trial

Sadaghiani, Safa; Fallahi, Soghra; Heshmati, Hossein; Teshnizi, Saeed Hosseini; Chaijan, Hooshang Abedini; Ebrahimi, Fahimeh Farzad Amir; Khorrami, Farhad; Poorrezaeian, Mina; Alizadeh, Faezeh

doi:10.3934/publichealth.2020009

Cited by 10 publications

(14 citation statements)

References 11 publications

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“…In a recent single-blinded trial, Sadaghiani et al enrolled 50 oligospermic and asthenospermic subjects who were also active smokers to investigate the effect of antioxidant supplementation (30 mg CoQ10, 8 mg zinc, 100 mg vitamin C, 12 mg vitamin E, 400 µg folic acid once a day and 200 mg selenium every other day) on semen parameters. After 3 months, the mean volume of sperm rose from 3.48 ± 1.44 to 3.71 ± 1.42 mL (p = 0.032), the total sperm count rose from 21.76 ± 23.02 to 23.22 ± 23.28 × 10 6 (p = 0.001), total sperm motility changed from 27.22 ± 13.69 to 31.85 ± 5.82% (p = 0.001); progressive motility increased from 9.82 ± 9.10 to 11.57 ± 10.18% (p = 0.001), and normal sperm morphology changed from 23.22 ± 23.28 to 33.60 ± 20.01% (p = 0.003) [30].…”

Section: Compound Combinations and Male Infertilitymentioning

confidence: 99%

Coenzyme Q10 and Male Infertility: A Systematic Review

et al. 2021

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Infertility affects 15% of couples worldwide. A male factor is involved in 50% of cases. The etiology of male infertility is poorly understood, but there is evidence for a strong association between oxidative stress (OS) and poor seminal fluid quality. For this reason, therapy with antioxidants is one of the cornerstones of empirical treatment of male infertility. Coenzyme Q10 (CoQ10)—an essential cofactor for energy production with major antioxidant properties—is commonly used to support spermatogenesis in idiopathic male infertility. This systematic review aims to elucidate the usefulness of CoQ10 supplementation in the treatment of male infertility, particularly with regard to semen quality assessed by conventional and advanced methods, and pregnancy rates. All studies report a beneficial effect of CoQ10 supplementation on semen parameters, although randomized controlled trials are a minority. Moreover, the optimal dosage of CoQ10 or how it can be combined with other antioxidant molecules to maximize its effect is unknown. However, CoQ10 is still one of the most promising molecules to treat idiopathic male infertility and warrants further investigation.

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Section: Compound Combinations and Male Infertilitymentioning

confidence: 99%

Coenzyme Q10 and Male Infertility: A Systematic Review

et al. 2021

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“…In a study conducted on 15 infertile patients with oligozoospermia and/or asthenozoospermia, Terai et al [ 142 ] reported that the combined administration of 1000 mg of AA, 750.1 mg of L-carnitine, 30 mg of zinc, 16.05 mg of astaxanthin, 90.26 mg of coenzyme Q 10 , 60.1 µg of vitamin B 12 and 150 mg of vitamin E three times a day for 12 weeks, significantly improved only total motile sperm count, with no effects on the other semen parameters. In a single-blinded clinical trial, Sadaghiani et al [ 143 ] reported that the daily administration for three consecutive months of 100 mg of AA, 30 mg of coenzyme Q 10 , 8 mg of zinc, 12 mg of vitamin E and 400 μg of folic acid, combined with that of 200 mg of selenium every other day, to 50 infertile oligozoospermic and asthenozoospermic male smokers, beneficially affected various morpho-functional semen parameters (concentration, pH, volume, total motility, morphology, count and progressive motility). A substantially different scenario was depicted by Steiner et al [ 144 ], who conducted a randomized controlled trial on 174 infertile males (categorized into oligozoospermic, asthenozoospermic, teratozoospermic and DNA fragmented patients), analyzed for sperm analysis anomalies and clinical outcome measures of fertility (pregnancy and live birth rates).…”

Section: Antioxidant-based Therapies In the Treatment Of Male Infementioning

confidence: 99%

“…As previously underlined, most of the studies focused their attention on the effectiveness of different vitamin E-containing antioxidant mixtures [ 138 , 139 , 140 , 141 , 142 , 143 , 144 , 158 ], thus rendering it difficult (if not impossible) to separate the effects of tocopherols from those of the other administered antioxidants. In this context, in a prospective, open-labeled, nonrandomized study conducted by Lipovac et al [ 175 ], 299 subfertile males with at least one recent pathological semen analysis were treated for 3 months either with 500 mg L-carnitine/twice a day ( n = 156) or with the combination of 440 mg L-carnitine + 250 mg L-arginine + 40 mg zinc +120 mg vitamin E + 80 mg GSH + 60 μg selenium + 15 mg coenzyme Q 10 + 800 μg folic acid/once a day ( n = 143).…”

Section: Antioxidant-based Therapies In the Treatment Of Male Infementioning

confidence: 99%

“…In addition to the previously mentioned studies reporting the CoQ 10 supplementation in combination with other compounds [ 138 , 141 , 142 , 143 , 175 , 176 ], Tirabassi et al [ 194 ] conducted an observational study on 20 patients affected by idiopathic asthenozoospermia and daily administered with 200 mg CoQ 10 and 2660 mg of D-aspartate for 3 months. Notwithstanding no increment of CoQ 10 in the seminal fluid of treated patients was recorded, the authors reported a significant improvement of sperm kinetic parameters and concomitantly decreased levels of ● NO, peroxynitrites and nitrosative stress-related damages to DNA after 3 months of administration [ 194 ].…”

Section: Antioxidant-based Therapies In the Treatment Of Male Infementioning

confidence: 99%

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Antioxidant-Based Therapies in Male Infertility: Do We Have Sufficient Evidence Supporting Their Effectiveness?

Amorini

Listorti²,

Bilotta³

et al. 2021

Antioxidants

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Under physiological conditions, reactive oxygen species (ROS) play pivotal roles in various processes of human spermatozoa. Indeed, semen requires the intervention of ROS to accomplish different stages of its maturation. However, ROS overproduction is a well-documented phenomenon occurring in the semen of infertile males, potentially causing permanent oxidative damages to a vast number of biological molecules (proteins, nucleic acids, polyunsaturated fatty acids of biological membrane lipids), negatively affecting the functionality and vitality of spermatozoa. ROS overproduction may concomitantly occur to the excess generation of reactive nitrogen species (RNS), leading to oxidative/nitrosative stress and frequently encountered in various human pathologies. Under different conditions of male infertility, very frequently accompanied by morpho-functional anomalies in the sperm analysis, several studies have provided evidence for clear biochemical signs of damages to biomolecules caused by oxidative/nitrosative stress. In the last decades, various studies aimed to verify whether antioxidant-based therapies may be beneficial to treat male infertility have been carried out. This review analyzed the results of the studies published during the last ten years on the administration of low-molecular-weight antioxidants to treat male infertility in order to establish whether there is a sufficient number of data to justify antioxidant administration to infertile males. An analysis of the literature showed that only 30 clinical studies tested the effects of the administration of low-molecular-weight antioxidants (administered as a single antioxidant or as a combination of different antioxidants with the addition of vitamins and/or micronutrients) to infertile males. Of these studies, only 33.3% included pregnancy and/or live birth rates as an outcome measure to determine the effects of the therapy. Of these studies, only 4 were case–control studies, and only 2 of them found improvement of the pregnancy rate in the group of antioxidant-treated patients. Additionally, of the 30 studies considered in this review, only 43.3% were case–control studies, 66.7% enrolled a number of patients higher than 40, and 40% carried out the administration of a single antioxidant. Therefore, it appears that further studies are needed to clearly define the usefulness of antioxidant-based therapies to treat male infertility.

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“…Hasil yang didapatkan setelah pemberian suplemen antioksidan (30 mg koenzim Q10, 8 mg seng, 100 mg vitamin C, 12 mg vitamin E, dan 400 mg asam folat sekali sehari selama 3 bulan dan 200 mg selenium setiap hari setelah makan siang), yaitu terjadi peningkatan spermatozoa setelah pemberian intervensi. 19 Penelitian ini dalam bentuk literature review memiliki kelebihan dan kekurangan. Kelebihannya adalah topik penelitian yang terkait vitamin C. Vitamin C atau sumber makanan yang mengandung vitamin C merupakan vitamin yang sudah dikenal luas di kalangan masyarakat dan sangat mudah ditemukan.…”

Section: Bahasanunclassified

Pengaruh Pemberian Vitamin C Terhadap Kualitas Spermatozoa Yang Terpapar Asap Rokok

Awuy

Purwanto

Mewo

2021

eBM

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Cigarettes can cause oxidative stress that may cause various health problems such as the decrease of spermatozoa quality. The disturbed state of spermatozoa results in a decrease quality of the spermatozoa which may effect fertility. Vitamin C is an antioxidant which is believed to affect improving the quality of spermatozoa. This study aimed to determine the effect of vitamin C on the quality of spermatoza exposed to cigarette smoke. This research was conducted by literature review using three databases, namely Google Scholar, Pubmed, and ClinicalKey. After being selected based on inclusion and exclusion criteria, there were 10 articles research for assessment. The results show that the decrease in spermatozoa concentration is due to the nicotine contained in cigarette smoke. By giving vitamin C, it can reduce oxidative stress which can cause lipid peroxidation, and then reduce the decrease in spermatozoa concentration. There is also an improvement in spermatozoa motility and morphology after vitamin C administration. Vitamin C as an antioxidant plays a role in fighting free radicals, so that the spermatozoa cell membrane remains protected. In conclusion, consumption of vitamin C shows an effect to improve the quality of spermatozoa exposed to cigarette smoke, including increasing/improving the concentration, morphology, and motility of spermatozoa.Keywords: vitamin C, spermatozoa, smoker Abstrak: Rokok menyebabkan terjadinya stres oksidatif yang dapat mengakibatkan berbagai gangguan kesehatan seperti penurunan kualitas spermatozoa. Keadaan spermatozoa yang terganggu mengakibatkan penurunan kualitas spermatozoa sehingga akan memengaruhi kesuburan. Vitamin C merupakan antioksidan yang dipercaya dapat memengaruhi peningkatan kualitas spermatozoa. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian vitamin C terhadap kualitas spermatoza yang terpapar asap rokok. Penelitian ini berbentuk literature review dengan pencarian data menggunakan tiga database yaitu Google Scholar, Pubmed, dan ClinicalKey. Setelah diseleksi berdasarkan kriteria inklusi dan eksklusi, didapatkan 10 artikel untuk dilakukan penilaian. Hasil penelitian menunjukkan bahwa penurunan konsentrasi spermatozoa disebabkan oleh kandungan nikotin dalam asap rokok. Pemberian vitamin C dapat menurunkan stres oksidatif yang dapat menyebabkan terjadinya peroksidasi lipid, kemudian menekan penurunan konsentrasi spermatozoa. Terdapat juga perbaikan motilitas dan morfologi spermatozoa setelah pemberian vitamin C. Vitamin C sebagai antioksidan berfungsi untuk menanggulangi radikal bebas, sehingga membran sel spermatozoa akan tetap terlindungi. Sebagai simpulan, pemberian vitamin C menunjukkan adanya pengaruh untuk meningkatkan kualitas spermatozoa yang terpapar asap rokok, meliputi peningkatan/perbaikan konsentrasi, morfologi, dan motilitas spermatozoa.Kata kunci: vitamin C, spermatozoa, asap rokok

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Effect of antioxidant supplements on sperm parameters in infertile male smokers: a single-blinded clinical trial

Cited by 10 publications

References 11 publications

Coenzyme Q10 and Male Infertility: A Systematic Review

Coenzyme Q10 and Male Infertility: A Systematic Review

Antioxidant-Based Therapies in Male Infertility: Do We Have Sufficient Evidence Supporting Their Effectiveness?

Pengaruh Pemberian Vitamin C Terhadap Kualitas Spermatozoa Yang Terpapar Asap Rokok

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