Effect of Antiemetics and Other Compounds on Protoveratrine Induced Emesis in Dogs

Weaver, Lawrence C.; Rahdert, Elizabeth; Richards, Alice B.; Abreu, Benedict E.

doi:10.1002/jps.2600530415

Cited by 6 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanism by which the veratrine HCl and related alkaloids evoke vomiting has been studied exclusively in mammals (e.g. cat and dog, Borison & Wang, 1953;Borison & Fairbanks, 1952;Swiss, 1952;Weaver et al, 1964). Whilst early studies implicated a direct action within the central nervous system more extensive studies by Borison & Fairbanks (1952) and Bobkov (1964) provided evidence for a peripheral site of action on the nodose ganglion, the location of the cell bodies of vagal afferents.…”

Section: Mechanisms Of Veratrine Hcl Induced Vomitingmentioning

confidence: 99%

Induction of Emesis by the Sodium Channel Activator Veratrine in the Lesser Spotted Dogfish, Scyliorhinus Canicula (Chondrichthyes: Elasmobranchii)

1998

View full text Add to dashboard Cite

This study provides the first quantitative description of the emetic reflex (vomiting) in the dogfish (Scyliorhinus canicula) by using veratrine HC1 (lOmgkg−1, i.p.), the sodium channel activator as a stimulus. Vomiting occurred within 10 min of injection. The most notable features of the response in the correct temporal sequence were: (i) head shaking with wide gaping of the mouth; (ii) lowering of the ventral buccal cavity and expansion of the pharyngeal cavity; (iii) contraction of the gill arches, the buccopharyngeal musculature and lowering of the jaw rapidly followed by the expulsion of gastric contents (pieces of fish). The expulsion sequence (ii and iii) took ~ 1 s. The significance of the vomiting reflex in the dogfish is discussed in terms of its protective function and as a component of normal feeding to periodically eject indigestible food residues.

show abstract

Section: Mechanisms Of Veratrine Hcl Induced Vomitingmentioning

confidence: 99%

Induction of Emesis by the Sodium Channel Activator Veratrine in the Lesser Spotted Dogfish, Scyliorhinus Canicula (Chondrichthyes: Elasmobranchii)

1998

View full text Add to dashboard Cite

show abstract

“…In Winer's study (20) (27), using the intravenous route, found no significant difference between protoveratrine A and protoveratrine B in dogs. Species differences are known to play a very important part in the emetic response to drugs (28-31), and it is quite possible that this disparity is due to a species difference.…”

Section: Discussionmentioning

confidence: 96%

Comparative Evaluation of the Emetic Effects of Some Natural and Semi-Synthetic Esters of Protoverine

Gujral¹

1972

Jpn.J.Pharmacol

View full text Add to dashboard Cite

Central antiemetic actions of pimozide and haloperidol in the dog

et al. 1979

View full text Add to dashboard Cite

Effect of Antiemetics and Other Compounds on Protoveratrine Induced Emesis in Dogs

Cited by 6 publications

References 3 publications

Induction of Emesis by the Sodium Channel Activator Veratrine in the Lesser Spotted Dogfish, Scyliorhinus Canicula (Chondrichthyes: Elasmobranchii)

Induction of Emesis by the Sodium Channel Activator Veratrine in the Lesser Spotted Dogfish, Scyliorhinus Canicula (Chondrichthyes: Elasmobranchii)

Comparative Evaluation of the Emetic Effects of Some Natural and Semi-Synthetic Esters of Protoverine

Central antiemetic actions of pimozide and haloperidol in the dog

Contact Info

Product

Resources

About