Effect of Antidepressant Medication on Morning and Evening Thyroid Function Tests During a Major Depressive Episode

Duval, Fabrice; Mokrani, Marie‐Claude; Crocq, Marc-Antoine; Jautz, Martine; Bailey, Paul; Diep, T.S.; Mâcher, Jean-Paul

doi:10.1001/archpsyc.1996.01830090081012

Cited by 53 publications

(41 citation statements)

References 69 publications

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“…Our finding that higher TSH, but not FT 4 , is related to response, is in agreement with studies measuring evening TSH concentrations (6,28). Other studies measuring TSH in the morning did not find such a relation (8)(9)(10)(11)(12).…”

Section: Discussionsupporting

confidence: 91%

“…These changes may be of clinical significance, since they have been related to response by some (6,7) but not all authors (8). So far, the nature of a relation between thyroid function and response seems unclear; Duval et al (6) described higher evening TSH concentrations in treatment responders, while Sullivan et al (7) found that non-response was predicted by a high delta TSH in the TRH test.…”

Section: Introductionmentioning

confidence: 99%

“…So far, the nature of a relation between thyroid function and response seems unclear; Duval et al (6) described higher evening TSH concentrations in treatment responders, while Sullivan et al (7) found that non-response was predicted by a high delta TSH in the TRH test. However, most studies were retrospective and included only small groups of patients (6,(9)(10)(11)(12). Furthermore, no studies so far included TPO antibodies in their analysis, although thyroid autoimmunity is an important determinant of TSH levels (13) or may be a predictor of response itself.…”

Section: Introductionmentioning

confidence: 99%

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Thyrotropin, but not a polymorphism in type II deiodinase, predicts response to paroxetine in major depression

Brouwer¹,

Appelhof²,

Peeters

et al. 2006

eur j endocrinol

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Objective: The determinants of response to antidepressant treatment in major depression are unknown at present. The aim of the present study was to establish whether response is predicted by Hypothalamus-Pituitary-Thyroid (HPT) axis parameters or by a recently discovered polymorphism in the enzyme type II deiodinase (DII), which catalyzes the production of T 3 in the brain. Design: We analyzed prediction of response to paroxetine treatment by calculating response rates per tertile of HPT-axis parameters and per DII genotype. Methods: Ninety-eight outpatients with major depression (DSM-IV) were included. Serum concentrations of TSH, FT 4 and delta TSH in a DEX/CRH-TRH test were measured. In addition, the presence of a polymorphism in the DII sequence (Thr92Ala) was determined. Results: The overall treatment response was 48 of 98 patients (49%). After exclusion of patients with subclinical hypothyroidism and/or TPO antibodies (nZ16), higher serum TSH significantly predicted response (response rate per tertile from low to high TSH: 36%, 42%, and 67%). Heterozygous patients for the DII polymorphism (44%) had slightly lower serum TSH (PZ0.03) as compared to patients with the wild-type DII (47%). The polymorphism was unrelated to treatment response. Conclusion: Higher serum TSH was associated with response to paroxetine in patients with major depression.European Journal of Endocrinology 154 819-825

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thyrotropin, but not a polymorphism in type II deiodinase, predicts response to paroxetine in major depression

Brouwer¹,

Appelhof²,

Peeters

et al. 2006

eur j endocrinol

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“…Existem estudos 75,76 , demonstrando que o tratamento com antidepressivos reduz os níveis plasmáticos de T 4 , sendo que os pacientes responsivos ao tratamento apresentam uma redução mais pronunciada no T 4 livre e no T 4 plasmático do que os não responsivos. O efeito dos antidepressivos e provavelmente também o efeito profilático da carbamazepina envolvem um efeito anti-tireoideo, pelo fato de que, com o uso dessas drogas, o T 3 e T 4 diminuem e o TSH aumenta 77 . Este fato nos leva a pensar em um hipertireoidismo associado.…”

Section: Atividade Do Eixo Hipotálamo-hipófise-tireóide (Hpt) Nos Traunclassified

“…Como os quadros de depressão recorrente podem estar mais relacionados ao espectro bipolar, é interessante observar que a persistência do embotamento do TRH parece estar associada a um aumento nas recaídas 77 . Duval et al (1996) 75 encontrou que pacientes com as menores taxas de TSH basal, ∆máxTSH e ∆∆máxTSH tinham a mais baixa taxa de resposta ao tratamento baseado no uso de antidepressivo, necessitando de outra estratégia terapêutica, como a administração de hormônios da tireóide como terapia coadjuvante. 4.…”

Section: Atividade Do Eixo Hipotálamo-hipófise-tireóide (Hpt) Nos Traunclassified

Neurobiologia do transtorno de humor bipolar e tomada de decisão na abordagem psicofarmacológica

Machado‐Vieira

Schwartzhaupt²,

Frey

et al. 2003

Rev. psiquiatr. Rio Gd. Sul

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INTRODUÇÃOO Transtorno do Humor Bipolar (THB) caracteriza-se por oscilações do humor que causam prejuízos significativos no âmbito biopsicossocial, com critérios específicos para seus subdiagnósticos (DSM-IV). O surgimento de novos fármacos com propriedade de estabilizar o humor, o refinamento diagnóstico, as estimativas de uma maior prevalência, o risco de suicídio, assim como os prejuízos sociais causados para o indivíduo portador do transtorno, sua família e a sociedade enfatizam a importân-cia de cada vez mais este transtorno ser estudado de forma sistemática, continuada e críti-ca. Este artigo avalia criticamente as opções já estudadas para tratamento farmacológico dos diferentes subtipos de THB, avaliando sua eficácia para as indicações específicas, bem como as perspectivas de novos estudos com fárma-cos que ainda apresentam resultados limitados, especialmente devido à não sistematização dos estudos clínicos feitos até o presente momento. FÁRMACOS UTILIZADOS E MECANISMOS DE AÇÃO LítioO lítio interfere no metabolismo do inositol trifosfato, responsável pela liberação do cálcio de seus depósitos intracelulares, possivelmente através da inibição de enzimas na rota de formação do inositol2,3. Há também outras hipóteses que justificam seu uso como estabilizador do humor:-por sua similaridade com outros elementos (sódio, potássio, cálcio e magnésio), eleva Neurobiologia do transtorno de humor bipolar e tomada de decisão na abordagem psicofarmacológica

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Psychostimulants for depression

Candy

Jones

Williams

et al. 2008

Cochrane Database of Systematic Reviews

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There is some evidence that in the short-term, PS reduce symptoms of depression. Whilst this reduction is statistically significant, the clinical significance is less clear. Larger high quality trials with longer follow-up and evaluation of tolerance and dependence are needed to test the robustness of these findings and, furthermore, to explore which PS may be more beneficial and in which clinical situations they are optimal.

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Effect of Antidepressant Medication on Morning and Evening Thyroid Function Tests During a Major Depressive Episode

Cited by 53 publications

References 69 publications

Thyrotropin, but not a polymorphism in type II deiodinase, predicts response to paroxetine in major depression

Thyrotropin, but not a polymorphism in type II deiodinase, predicts response to paroxetine in major depression

Neurobiologia do transtorno de humor bipolar e tomada de decisão na abordagem psicofarmacológica

Psychostimulants for depression

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