Effect of antibiotic use on the prevalence of symptomatic vulvovaginal candidiasis

Spinillo, Arsenio; Capuzzo, Ezio; Acciano, S; Santolo, Antonella De; Zara, Francesca

doi:10.1016/s0002-9378(99)70141-9

Cited by 73 publications

(56 citation statements)

References 4 publications

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“…yeasts were isolated: Trichosporon species and S.cerevisiae. C.albicans was the predominant species isolated in other studies (7)(8)(9)(10)(11)(12)(13)(14) which concurs with the findings in this study. The distribution of the non-albicans species, however, differed in different studies.…”

Section: Discussionsupporting

confidence: 92%

“…Most of the findings in this study were within these ranges except for C.famata, Trichosporon species and S. cerevisiae which were more frequent in this study. C.tropicalis was also isolated in these studies but was not found in the current study (7)(8)(9)(10)(11)(12)(13)(14).…”

Section: Discussioncontrasting

confidence: 48%

“…The distribution of the non-albicans species, however, differed in different studies. The most commonly isolated non-albicans species differed as C.glabrata (7)(8)(9)(10)(11)(12)(13) and C. parapsilosis (14). The second most common non-albicans species differed in the different studies as C.glabrata (14), C. tropicalis (8,10,11) C. parapsilosis (12), C. famata (9) and C.krusei (7).…”

Section: Discussionmentioning

confidence: 99%

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Species distribution and antifungal sensitivity patterns of vaginal yeasts

Mutua

Revathi²,

Machoki³

2010

E Af Med Jrnl

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Objectives:To identify yeast isolates in vaginal specimens to species level and determine their antifungal susceptibility patterns. Design: Cross-sectional laboratory-based study. Setting: The Aga Khan University Hospital (AKUH), Nairobi. Subjects: Yeast isolates from high vaginal swabs presented to the laboratory for culture and sensitivity were identified to species level using the API Candida system and subjected to broth microdilution susceptibility testing. Main outcome measures: Frequency tables and graphs were used to summarise the data. Susceptibility data was analysed by the non-parametric Fisher's exact test. P<0.05 was considered statistically significant. Results: A total of 101 yeasts were studied. C.albicans was the prominent species (69.3%) followed by C. glabrata (12.9%), C. famata (5.0%), C. krusei (3.0%), Trichosporon species (3.0%) and S.cerevisiae (3.0%), C.parapsilosis (1.0%). Three (3.0%) of the isolates had profiles that fell between C. glabrata and C. famata. The percentages of C. albicans susceptible to flucytosine, amphotericin B, fluconazole and itraconazole were 94.3, 92.9, 100 and 90 respectively; that of non-albicans isolates were 93.5, 80.6, 77.4 and 29 respectively. There was no significant difference (p>0.05) between the susceptibility of C.albicans and non-albicans isolates to flucytosine and amphotericin B, however there was a significant difference (p<0.05) to fluconazole and itraconazole. Conclusions: C. albicans was the predominant cause of vulvovaginal candidiasis in this study, and demonstrated good susceptibility to antifungal agents tested. A significant number of non-albicans yeasts were identified; these demonstrated reduced susceptibility to all drugs, in particular to the azoles which are commonly used for treatment of vaginal candidiasis. The isolation of non-albicans yeasts may have clinical implication given their reduced susceptibility to antifungals.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

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Species distribution and antifungal sensitivity patterns of vaginal yeasts

Mutua

Revathi²,

Machoki³

2010

E Af Med Jrnl

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“…Our results are consistent with previous studies that demonstrated that antibiotic use seems to be a short-term risk factor for symptomatic VVC and that excess risk occurs in the first month after antibiotic use. 10,31,35 In 2 older clinical studies by Caruso 36 and Oriel and Waterworth, 37 the prevalence of a vaginal culture of Candida increased from approximately 10% at baseline to approximately 30% after 2 to 3 weeks of treatment with tetracyclines in nonpregnant adult women, which was similar to our finding. Unfortunately, both studies failed to report the percentages of women who developed vaginal symptoms.…”

Section: Discussionsupporting

confidence: 85%

“…1,2,7,14 For example, some case-control studies 19,20 found no evidence of an association between antibiotic agents and symptomatic VCC, whereas others reached an opposite conclusion. 10,13,21 The results from a prospective study of 250 pregnant women concluded that extensive antibiotic use posed little risk for the development of yeast infection. 22 In addition to antibiotics, other hypothesized risk factors for VVC include pregnancy; a history of VVC; sexual practices (especially receptive oral sex); oral hormones, either contraceptive or replacement therapy; diabetes mellitus and other immunodeficiency states; and African American ethnicity.…”

mentioning

confidence: 99%

Effect of Antibiotics on Vulvovaginal Candidiasis: A MetroNet Study

Xu¹,

Schwartz²,

Bartoces³

et al. 2008

The Journal of the American Board of Family Medicine

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Purpose: Vulvovaginal candidiasis (VVC) is believed common after systemic antibiotic therapy, yet few studies demonstrate this association. In this pilot study, we evaluate the effect of short-course oral antibiotic use on VVC.Methods: Nonpregnant women aged 18 to 64 years who required >3 days oral antibiotics for nongynecological diseases were recruited from a family medicine office. Age-matched (؎5 years) women seen in the same clinic for noninfectious problems were recruited as controls. The main outcomes are incidence of symptomatic VVC and prevalence of positive vaginal Candida culture 4 to 6 weeks after antibiotics.Results Although vulvovaginal candidiasis (VVC) is one of the most common forms of vaginitis in women of childbearing age, its etiology remains poorly understood.

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Vulvovaginitis

Sobel¹,

Nyirjesy²

2020

Female Sexual Pain Disorders

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Effect of antibiotic use on the prevalence of symptomatic vulvovaginal candidiasis

Cited by 73 publications

References 4 publications

Species distribution and antifungal sensitivity patterns of vaginal yeasts

Species distribution and antifungal sensitivity patterns of vaginal yeasts

Effect of Antibiotics on Vulvovaginal Candidiasis: A MetroNet Study

Vulvovaginitis

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