Effect of anti TNFalpha therapy on arterial diameter and wall shear stress and HDL cholesterol

Irace, Concetta; Mancuso, G.; Fiaschi, Elio; Madia, Angela; Sesti, Giorgio; Gnasso, Agostino

doi:10.1016/j.atherosclerosis.2004.04.031

Cited by 86 publications

(61 citation statements)

References 26 publications

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“…115 Decrease in HDL-C levels, peripheral arteries diameters, and increase of blood wall shear stress in RA patients received infliximab therapy were also observed. 116 However, another study suggested that in active RA patients, infliximab therapy (3 mg kg À1 at weeks 0, 2, and 6) was associated with a significant increase of both TC and HDL-C levels, which correlated with decreasing disease activity. 19 While in patients with refractory, infliximab administration (3 mg kg À1 at weeks 0, 2, 6, 14, 22, and 30) associated with important increases in TC, LDL-C, HDL-C but has no significant beneficial effect on the atherogenic index (TC/ HDL-C, LDL-C/HDL-C).…”

Section: Effects Of Infliximab On Lipid Metabolism -Human Studiesmentioning

confidence: 99%

TNF‐α, a potent lipid metabolism regulator

Chen

Xun

Chen³

et al. 2009

Cell Biochemistry & Function

190

120

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As a multifunctional cytokine, tumor necrosis factor alpha (TNF-a) exerts a series of biological actions in different cells, tissues, organs, and species and has been demonstrated to regulate and interfere with energy metabolism, especially lipid homeostasis. A large body of researches suggested that the effects of TNF-a on lipid metabolism mainly include five aspects: (1) suppresses free fatty acid (FFA) uptake and promotes lipogenesis; (2) induces lipolysis; (3) inhibits lipid-metabolism-related enzymes activity; (4) regulates cholesterol metabolism; (5) regulates other adipocyte-derived adipokines. The molecular mechanisms underlying these actions are complex and several signal transduction pathways might be involved. Regulation of metabolism-related gene expression at transcriptional and protein levels and impact on enzymes activity might be of importance. Identification and verification of these pathways might provide novel potential strategies and drug targets for dyslipidemia therapy. However, the inconsistent and even conflict conclusions on lipid profile drawn from human subjects after infliximab therapy poses the possibility that the effect of TNF-a on lipid metabolism might be more complicated than it appeared to be.

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Section: Effects Of Infliximab On Lipid Metabolism -Human Studiesmentioning

confidence: 99%

TNF‐α, a potent lipid metabolism regulator

Chen

Xun

Chen³

et al. 2009

Cell Biochemistry & Function

190

120

View full text Add to dashboard Cite

show abstract

“…Conflicting data probably due to selection of patients, and duration of treatment were published on the effect of anti TNF therapy in reducing the risk of cardiovascular disease in patients with RA (11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Long-term anti-tumour necrosis factor therapy reverses the progression of carotid intima–media thickness in female patients with active rheumatoid arthritis

et al. 2009

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“…В дальнейшем C. Irace и соавт. [96] подтвердили временное увеличение ПЗВД после инфузии ингибиторов ФНОα, но предположи-ли, что этот эффект был обусловлен системной вазоконст-рикцией, вероятно, из-за антагонизма вазодилататорных свойств ФНОα, а не из-за улучшения функции клеток эндо-телия. Позднее P.I.…”

Section: с о в P E м е н н а я р е в м а т о л о г и я № 4 ' 1 2 о б unclassified

“…нов, клеточных молекул адгезии и показателями липидного спектра крови, подтверждая концепцию о вкладе хрониче-ского воспаления в развитие дислипидемии при РА. В настоящее время большинство работ [96,[110][111][112][113][114][115][116][117][118][119][120][121] по-священо изучению влияния ингибиторов ФНОα на липид-ный спектр крови у пациентов с РА (табл. 3).…”

Section: в л и я н и е и н г и б и т о р о в ф н о α н а п з в д и т unclassified

“…С. Irace и соавт. [96] на следующий день после инфузии ИНФ отметили значительное уменьшение уровня ХС ЛВП, который возвращался к исходному на 6-й неделе терапии. E. Cauza и соавт.…”

Section: в л и я н и е и н г и б и т о р о в ф н о α н а п з в д и т unclassified

See 1 more Smart Citation

Ihmor necrosis factor-a inhibitors and cardiovascular risk in rheumatoid arthritis

Попкова¹,

Новикова²,

Насонов³

2012

Modern Rheumatology Journal

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Effect of anti TNFalpha therapy on arterial diameter and wall shear stress and HDL cholesterol

Cited by 86 publications

References 26 publications

TNF‐α, a potent lipid metabolism regulator

TNF‐α, a potent lipid metabolism regulator

Long-term anti-tumour necrosis factor therapy reverses the progression of carotid intima–media thickness in female patients with active rheumatoid arthritis

Ihmor necrosis factor-a inhibitors and cardiovascular risk in rheumatoid arthritis

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