Effect of anomalous cuticular phospholipids on penetration of insecticides in susceptible and resistant house flies

Patil, Vasant L.; Guthrie, F. E.

doi:10.1016/0048-3575(79)90043-9

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…For instance, in houseflies (Musca domestica) there is evidence that resistance to dichlorvos may provide some resistance to dieldrin, possibly because there is a lowered penetration rate of the chemical through the cuticle (Gerolt 1974). The penetration rate may be influenced by changes in the phospholipid structure of the cuticle selected by one chemical, but which may then influence the penetration rate of an unrelated chemical (Patil and Guthrie 1979). Hence cross-resistance may occur by general changes in cuticular structure and may also be influenced by excretion mechanisms that may have a low specificity towards a particular chemical (Matthews 1980).…”

Section: Discussionmentioning

confidence: 99%

Dieldrin and Diazinon Resistance in Populations of the Australian Sheep Blowfly, Lucilia cuprina, from Sheep-grazing Areas and Rubbish Tips

McKenzie¹

1984

Aust. Jnl. Of Bio. Sci.

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Populations of L. cuprina collected from adjacent sheep-grazing areas and rubbish tips in Victoria (Mansfield and Warrnambool) and New South Wales (Lismore) were tested for resistance to the insecticides diazinon and dieldrin. Populations from sheep-grazing areas had a significantly higher diazinon Rop-l allele frequency than those from adjacent tips with the Victorian populations being more resistant than those from Lismore. Victorian sheep and tip populations had similar gene frequencies at the dieldrin resistance locus, but the Rdl allele frequency was significantly greater in the population at the tip than in the population from the sheep-grazing area at Lismore. The Rdl allele is at a higher frequency in flies from the Lismore area than in Victorian populations. The results at both loci are explained by a balance of selection and gene flow between sheep and tip populations and by selective differences between geographical areas.The exceptionally high frequency of the dieldrin Rdl allele in populations at the Lismore tip may be partially explained by the use of dichlorvos for fly control. Dosage mortality curve and genetic analyses suggest that dichlorvos (an organophosphorus compound) may select at the dieldrin resistance locus. Possible mechanisms for this are discussed.The consequences of genetic differentiation between L. cuprina populations within a region for an autocidal control program are considered.Extra keyword: microdifferentiation.

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Section: Discussionmentioning

confidence: 99%

Dieldrin and Diazinon Resistance in Populations of the Australian Sheep Blowfly, Lucilia cuprina, from Sheep-grazing Areas and Rubbish Tips

McKenzie¹

1984

Aust. Jnl. Of Bio. Sci.

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Activity of abamectin against larval stages of Spodoptera littoralis boisduval and Heliothis armigera hübner (Lepidoptera: Noctuidae) and possible mechanisms determining differential toxicity

Christie

Wright

1990

Pestic. Sci.

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Marked changes in the relative toxicity of topically‐applied abamectin were found between larval instars of Spodoptera littoralis, toxicity decreasing up to the fifth instar but increasing over 500‐fold (at LD50 level) in the sixth instar. By contrast, the toxicity of abamectin remained constant from fifth to sixth instar Heliothis armigera and there was an increase in the toxicity of two chemically unrelated insecticides, malathion (4‐fold) and lambda‐cyhalothrin (2.5‐fold), from fifth to sixth instar S. littoralis. Prior topical application or injection of the microsomal oxidase inhibitor, piperonyl butoxide (PB) increased the toxicity of abamectin (6–8 and 16‐fold respectively) against fifth instar S. littoralis, while topically‐applied PB increased the proportion of radioactivity present as abamectin in the ventral nerve cord of this instar following topical application with [3H]abamectin. Topically‐applied PB also enhanced the toxicity of abamectin against third (4‐fold) and fourth instar (5‐fold) S. littoralis but had no significant effect on sixth instar S. littoralis, fifth instar H. armigera, or on the toxicity of malathion and lambda‐cyhalothrin against fifth instar S. littoralis. Topical application of the esterase inhibitor, S,S,S‐tributyl phosphorothioate (DEF) significantly increased the toxicity of abamectin at the LD50 level (3‐fold) against fifth instar S. littoralis. The toxicity of injected abamectin against fifth instar S. littoralis was greater (20‐fold) than with topical application but injected abamectin was less toxic (2‐fold) against sixth instar S. littoralis and had no significant effect on fifth instar H. armigera. It is suggested that differential toxicity of abamectin is due in part to greater metabolism and reduced penetration in fifth instar S. littoralis than in sixth instar S. littoralis or fifth instar H. armigera.

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The genetic basis of insecticide resistance in the house fly: Evidence that a single locus plays a major role in metabolic resistance to insecticides

Plapp

1984

Pesticide Biochemistry and Physiology

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Effect of anomalous cuticular phospholipids on penetration of insecticides in susceptible and resistant house flies

Cited by 5 publications

References 14 publications

Dieldrin and Diazinon Resistance in Populations of the Australian Sheep Blowfly, Lucilia cuprina, from Sheep-grazing Areas and Rubbish Tips

Dieldrin and Diazinon Resistance in Populations of the Australian Sheep Blowfly, Lucilia cuprina, from Sheep-grazing Areas and Rubbish Tips

Activity of abamectin against larval stages of Spodoptera littoralis boisduval and Heliothis armigera hübner (Lepidoptera: Noctuidae) and possible mechanisms determining differential toxicity

The genetic basis of insecticide resistance in the house fly: Evidence that a single locus plays a major role in metabolic resistance to insecticides

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