Effect of Ankaferd Blood Stopper on air leakage in the lung and prevention of bleeding: an experimental study

Abstract

BackgroundAir leakage and hemorrhage are important causes of morbidity and mortality in operations and traumas of the lung. Ankaferd Blood Stopper is a herbal product used for stopping hemorrhage. In our study, we investigated the efficacy of Ankaferd Blood Stopper in the prevention of air leakage in the lung and bleeding.MethodsA total of twenty-one Wistar-Albino rats weighing 240 ± 20 grams were used in our study. An equal amount of injury was created in all groups by performing left thoracotomies. No interventions were made on tissue injury in the first group, and suturing was performed in the second group, and Ankaferd was applied in the third group. Air leakage and duration of bleeding were recorded in all groups.ResultsA statistically significant difference was found between the three groups in terms of air leakage time (p = 0,0001) and bleeding time (p = 0,0001). While a significant effect of Ankaferd was detected in terms of air leakage compared to standard surgery (p = 0,017), no difference was found in terms of bleeding time.ConclusionsAnkaferd Blood Stopper ceases the air leakage in the lung parenchyma significantly and effectively. No significant difference is seen compared to the standard surgery group, although it ceases bleeding significantly.

New hemostatic agent: the effect of Ankaferd Blood Stopper on healing wounds in experimental skin incision model

“…Using an animal model, Kose et al demonstrated that ABS is a potent hemostatic agent for cutaneous bleeding resulting from surgical skin defects (13). The effects of ABS in preventing liver lacerations, partial nephrectomies, air leakage into the lung, and bleeding have been demonstrated via animal studies (14)(15)(16)(17). In another animal study, İşler et al reported that ABS causes new bone formation and reductions in necrosis and inflammation in a rat tibial defect model (18).…”

Beneficial effects of Ankaferd Blood Stopper on dermal wound healing: an experimental study

“…Kılıçgün et al (13) investigated the efficacy of ABS in the prevention of air leakage in the lungs and bleeding in an animal experiment. The results showed that ABS terminated air leakage in the lung parenchyma significantly and effectively.…”

A Placebo-Controlled, Randomized, Double-Blinded, Cross-Over Phase-I Clinical Study Indicating the Safety of Topical Ankaferd Hemostat in Healthy Volunteers

“…[12][13][14][15] The hemostatic effects of ABS have been demonstrated by in vitro and in vivo studies in the Literature. [16][17][18][19][20][21][22][23][24][25][26][27][28][29] The topical application of ABS as a hemostatic agent in the external hemorrhages and during dental interventions constituted the first hints about the safety and efficacy of ABS in humans. 13 A recent in vitro study suggested that topical application of ABS to ocular surfaces could affect cellular constituents.…”