Effect of angiotensin II and saralasin on motor activity and the passive avoidance behavior of rats

Braszko, Jan J.; Wiśniewski, K

doi:10.1016/0196-9781(88)90150-7

Cited by 50 publications

(18 citation statements)

References 8 publications

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“…Effective electric shock was preliminarily determined according to the previous studies. 10,11 Through a series of these procedures, the risk and its avoidance were engraved on their memory.…”

Section: Estimation Of Learning Ability By Passive Avoidance Taskmentioning

confidence: 99%

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Long-Term Inhibition of Renin-Angiotensin System Sustains Memory Function in Aged Dahl Rats

Hirawa¹,

Uehara²,

Kawabata³

et al. 1999

Hypertension

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Abstract-The Dahl salt-sensitive (DS) rat, a genetic model of salt-induced hypertension in humans, is more likely to develop severe vascular injuries than a rat with spontaneous hypertension. We designed an experiment to scrutinize the effects of renin-angiotensin inhibition on cognitive dysfunction in the aged, normotensive DS with a passive avoidance test. Eighteen months of treatment with a very low dose of the angiotensin-converting enzyme (ACE) inhibitor cilazapril (2.5 g/mL in drinking water) or the angiotensin II type 1 receptor antagonist E4177 did not reduce blood pressure throughout the experiment, although in the low dose cilazapril group (12.5 g/mL in drinking water), blood pressure dropped within 6 months after treatment began. The cilazapril treatments dose-dependently improved memory function in the aged, normotensive DS fed a low-salt diet compared with the untreated, control rats. This improvement was associated with significant increases in hippocampal CA1 cells and capillary densities in the CA1 regions compared with those in the untreated DS. Similarly, E4177 slightly improved the memory dysfunction observed in the aged DS. The cells in the hippocampal CA1 region were restored slightly, but the capillary densities were not influenced by the receptor antagonist. On the other hand, the ACE inhibitor and receptor antagonist both attenuated urinary protein excretions with an improvement of glomerular sclerosis. These data suggest that long-term treatment with an ACE inhibitor improves memory dysfunction probably through restoration of capillary and hippocampal cells. The effects are due to the inhibition of the angiotensin II type 1 receptor and probably to the enhancement of the kallikrein-kinin system. (Hypertension. 1999;34:496-502.)Key Words: cilazapril Ⅲ angiotensin-converting enzyme inhibitors Ⅲ receptors, angiotensin Ⅲ memory Ⅲ cognition Ⅲ rats, aging Ⅲ aging R ecent advances in vascular physiology have emphasized an integration of multiple risk factors that form vascular lesions in patients with various disorders that affect the cardiovascular system. The understanding of the process of vascular lesion development has led to the establishment of pharmacological and nonpharmacological strategies for the prevention of vascular damage in hypertension, hyperlipidemia, or abnormal glucose metabolism. In addition to such acquired forms of risk factors, some inevitable factors, eg, gender, genetic loading, and aging, contribute to the progression of vascular injuries. Among these factors, aging is particularly important. The development of a therapeutic strategy for the aging population is urgently needed. In Japan, by year 2015, people Ն65 years of age will constitute 25% of the population, and worldwide, by year 2025, this population will have doubled. In addition, Ϸ50% of dementia or cognitive dysfunction in the elderly are attributable to cerebrovascular lesions. 1 The elucidation of the mechanism of cerebrovascular lesions related to the process of aging provides a useful strategy to preven...

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Section: Estimation Of Learning Ability By Passive Avoidance Taskmentioning

confidence: 99%

“…The apparatus had a stainless-steel grid floor, and the chambers were separated by a slit door. 10,11 Each animal was initially placed in a safe and lighted room with the slit door closed. After 60 seconds of equilibrium stabilization, the slit door to the dark chamber was opened.…”

Section: Estimation Of Learning Ability By Passive Avoidance Taskmentioning

confidence: 99%

Long-Term Inhibition of Renin-Angiotensin System Sustains Memory Function in Aged Dahl Rats

Hirawa¹,

Uehara²,

Kawabata³

et al. 1999

Hypertension

View full text Add to dashboard Cite

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“…To assess learning ability, we performed a passive avoidance test according to the standard method described previously (4,15,16). This is an established test to assess memory function in the field of behavioral pharmacology.…”

Section: Discussionmentioning

confidence: 99%

“…Basic behavioral activity and movement were assessed using the open-field test according to the method of Braszko and Wisniewski (15). In the second trial of the frequency of crossing in the open-field, there was no statistical difference; however, in the third trial, the high-dose dilazep treatment significantly improved the basal movement, as compared with the control group (Fig.…”

Section: Behavior and Learning Abilitymentioning

confidence: 99%

“…After the rats were acclimated to the room, they were trained in a conventional step-through passive avoidance apparatus divided into a light and a dark chamber. The apparatus had a stainless-steel grid floor and the chambers were separated by a slit door (4,15,16). Each animal was placed initially in a safe and lighted room with the slit-door closed.…”

Section: Estimation Of Learning Ability By Passive Avoidance Taskmentioning

confidence: 99%

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Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

et al. 2003

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Among the consequences of the increasing prolongation of lifespan is a worldwide increase in the number of cases of dementia or impaired cognition. In the present study, to test the hypothesis that mechanisms independent of high blood pressure are involved in maintaining cognitive function, we assessed the effects of long-term dilazep treatment on cognitive dysfunction in normotensive Dahl salt-sensitive (Dahl S) rats fed a low-salt diet, using the standard passive avoidance test. Normotensive Dahl S rats fed a 0.3% NaCl diet were treated for 6 months with low-dose dilazep (2.5 g/ml in drinking water) or high-dose dilazep (12.5 g/ml).

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Cardiovascular therapeutics: A new potential for anxiety treatment?

Repova

Aziriova

Krajcirovicova

et al. 2022

Medicinal Research Reviews

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Besides the well-recognized risk factors, novel conditions increasing cardiovascular morbidity and mortality are emerging.Undesirable emotions and behavior such as anxiety and depression, appear to participate in worsening cardiovascular pathologies. On the other hand, deteriorating conditions of the heart and vasculature result in disturbed mental and emotional health. The pathophysiological background of this bidirectional

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Effect of angiotensin II and saralasin on motor activity and the passive avoidance behavior of rats

Cited by 50 publications

References 8 publications

Long-Term Inhibition of Renin-Angiotensin System Sustains Memory Function in Aged Dahl Rats

Long-Term Inhibition of Renin-Angiotensin System Sustains Memory Function in Aged Dahl Rats

Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

Cardiovascular therapeutics: A new potential for anxiety treatment?

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