Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

Numabe, Atsushi; Ara, Nusrat; Hakamada-Taguchi, Rie; Suzuki, Noriko; Hirawa, Nobuhito; Kawabata, Yusuke; Negoro, Toshiyuki; Nagata, Toshiaki; Goto, Atsuo; Toyo’oka, Toshimasa; Fujita, Toshiro; Uehara, Yoshio

doi:10.1291/hypres.26.185

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Recently, Yamagishi et al [22] reported that platelet activation plays a major role in the development and progression of rat diabetic nephropathy. Numabe et al [23] reported that treatment with dilazep through vascular and nonvascular effects maintains brain function in animals susceptible to vascular injury and organ dysfunction. Dilazep dihydrochloride is commonly used in patients with IgA nephropathy, ischaemic heart disease, polycystic kidney disease or diabetic nephropathy [8,21,24,25], and it is known to cause an increase in cerebral blood flow [6].…”

Section: Discussionmentioning

confidence: 99%

Silent cerebral infarction in patients with type 2 diabetic nephropathy. Effects of antiplatelet drug dilazep dihydrochloride

Nakamura

Kawagoe

Matsuda

et al. 2004

Diabetes Metabolism Res

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Section: Discussionmentioning

confidence: 99%

Silent cerebral infarction in patients with type 2 diabetic nephropathy. Effects of antiplatelet drug dilazep dihydrochloride

Nakamura

Kawagoe

Matsuda

et al. 2004

Diabetes Metabolism Res

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“…Therefore, some platelet-derived miRNAs may play a potential role in platelet-associated pathologic processes, including vascular lesions. In a similar context, recent studies have reported enhanced platelet activation and aggregation in MCI in correlation with AD progression, and an ameliorating effect of anti-platelet drugs on cognitive decline [44,45]. Based on these results, we hypothesized that some miRNAs in platelets are important in the process of pathologic changes in Aβ(+)MCI patients that are known to progress to AD faster than Aβ(−)MCI patients.…”

Section: Discussionmentioning

confidence: 76%

Downregulated Platelet miR-1233-5p in Patients with Alzheimer’s Pathologic Change with Mild Cognitive Impairment is Associated with Aβ-Induced Platelet Activation via P-Selectin

Lee

Kim

Lee

et al. 2020

JCM

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MicroRNAs (miRNAs) have been proposed as a promising biomarker for various diseases including Alzheimer’s disease (AD). More attention has recently been focused on the diagnosis and treatment at earlier stage of mild cognitive impairment (MCI) for preventing its progression to AD. To identify potential pathologic markers for Aβ(+)MCI (Alzheimer’s pathologic change with MCI), we investigated miRNA expression profiles in the platelets from patients with Aβ(+)MCI, in comparison with those from Aβ(−)MCI (Non-Alzheimer’s pathologic change with MCI) and CNI (cognitively normal individuals). We found that let-7i-5p, miR-125a, miR-1233-5p, and miR-6787-5p were significantly downregulated, while miR-6880-5p expression was upregulated. Of these, only miR-1233-5p was significantly downregulated by Aβ treatment in both human platelets and their precursor megakaryocytes (MEG-01 cells). We explored the role of miRNAs by using miRNA mimics or inhibitors, and found that the diminished level of miR-1233-5p was associated with Aβ-induced increase in the expression of P-selectin and cell adhesion to fibronectin. Our results further indicated that Aβ-induced increase in platelet/MEG adhesion to fibronectin is likely mediated via P-selectin. In conclusion, this study suggests the downregulation of platelet-derived miR-1233-5p as a pathologic marker for Aβ(+)MCI.

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“…16 The measurement was expressed as the percentage of mesangial matrix to the whole area of a glomerulus tested. We scanned 100 glomeruli per each mouse.…”

Section: Functional and Morphological Analyses Of The Kidney Of C57blmentioning

confidence: 99%

Inhibition of Hydroxymethylglutaryl-Coenzyme A Reductase Reduces Th1 Development and Promotes Th2 Development

Hakamada-Taguchi

Uehara

Kuribayashi

et al. 2003

Circulation Research

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155

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Abstract-Several prospective clinical studies have indicated that hydroxymethylglutaryl-coenzyme A reductase inhibitors, statins, prevent cardiovascular events in part through their antiinflammatory properties. Because inflammation is positively and negatively regulated by T helper (Th) 1 cells and Th2 cells, respectively, we examined the effects of statins on the Th polarization in vitro and in vivo. Here we demonstrated that the statins tested, ie, cerivastatin, simvastatin, lovastatin, and atorvastatin, promoted Th2 polarization through both inhibition of Th1 development and augmentation of Th2 development of CD4 ϩ T cells primed in vitro with anti-CD3 antibody and splenic antigen-presenting cells. Cerivastatin exerted most potent effect on modulation of Th1/Th2 development, and the effect was completely abrogated by an addition of mevalonate. Consistent with in vitro experiments, cerivastatin treatment decreased IFN-␥ production of lymph node cells from mice immunized with ovalbumin emulsified in complete Freund's adjuvant, indicating that Th1 development is also suppressed in an in vivo proinflammatory environment. In this murine model, cerivastatin significantly reduced mesangial matrix expansion of glomeruli in the kidney and attenuated proteinuria. The decrease of glomerular sclerosis by cerivastatin treatment was positively related to the suppression of interferon (IFN)-␥-producing Th1 response in draining lymph node cells. Hence, these findings strongly suggest that statins' inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase regulates Th1/Th2 polarization in vivo and such a mechanism possibly plays a pathophysiological role in immune-related glomerular injury.

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Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

Cited by 3 publications

References 20 publications

Silent cerebral infarction in patients with type 2 diabetic nephropathy. Effects of antiplatelet drug dilazep dihydrochloride

Silent cerebral infarction in patients with type 2 diabetic nephropathy. Effects of antiplatelet drug dilazep dihydrochloride

Downregulated Platelet miR-1233-5p in Patients with Alzheimer’s Pathologic Change with Mild Cognitive Impairment is Associated with Aβ-Induced Platelet Activation via P-Selectin

Inhibition of Hydroxymethylglutaryl-Coenzyme A Reductase Reduces Th1 Development and Promotes Th2 Development

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