Effect of andrographolide derivative Yanhuning on in vivo Candida albicans biofilms in rats

Shi, Guoping; Yan, Yuanyuan; Shao, Jing; Zhang, Meng-Xiang; Lu, K. L.; Wang, Tianming; Wang, Changzhong

doi:10.4268/cjcmm20141525

Cited by 2 publications

(1 citation statement)

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“…With the high rates of anaphylaxis and anaphylactic shock (97.9%), it is significant to inquire the detailed allergic history from the patients and consider the allergic constitution before taking XYP [65]. Moreover, we need to pay more attention to the allergic histories of andrographis preparations such as lianbizhi injection [66], yanhuning injection [67], and chuanhuning injection [68].…”

Section: Discussionmentioning

confidence: 99%

Normative Application of Xiyanping Injection: A Systematic Review of Adverse Case Reports

Chen

Kwong

Zheng

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Purpose To summarize the characteristics and the relevant factors and to give references for preventing adverse drug reactions (ADRs) associated with xiyanping (XYP), we provide a systematic review of adverse case reports about XYP. Methods Seven medical databases were searched from inception to January 2018. Case reports detailing ADRs associated with XYP were included. Data were extracted independently by two reviewers. After the assessment of causality and severity, we carried out a descriptive analysis for the relevant ADRs. Results Forty-three articles involving a total number of 55 cases were included. Eight cases were off-label drug use. In the remaining 47 cases, 26 (55.3%) had probable causality and 23 (48.9%) were serious cases. XYP used in children (≤14 years old) accounted for 66.0%. Respiratory diseases (83.0%) were major primary diseases. No allergic history mentioned (55.3%) and unspecific drug combination (59.6%) were common in these reports. As for ADR types, anaphylaxis and anaphylactic shock were up to 97.9%. ADRs happened mostly when applying XYP within 30 minutes (70.2%) and the majority (95.7%) were cured when treated in time. Conclusions Clinicians and patients are supposed to obey the package insert of XYP in clinical application. Through the results of XYP, normalization of ADR reports is also worthy of attention. High-quality researches are required to improve the drug instruction and evaluate the safety of XYP in effective diseases and different age groups. Mechanism of ADRs aiming at the hypersensitivity and the drug combination should still be further identified.

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Section: Discussionmentioning

confidence: 99%

Normative Application of Xiyanping Injection: A Systematic Review of Adverse Case Reports

Chen

Kwong

Zheng

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity

2016

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Enterovirus 71 (EV71) is one of the causative agents of hand, foot, and mouth disease (HFMD), which sometimes leads to severe neurological disease and death in the Asia–Pacific region. In Chinese medicine, HFMD is caused mainly by an accumulation of damp-heat and toxicity in the body. No effective drugs are currently available for the treatment and prevention of EV71 infection. This review summarizes the potential Chinese herbal extracts and isolated compounds with antiviral activity against EV71 and their clinical applications, especially those categorized as heat-clearing and detoxifying.

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Effect of andrographolide derivative Yanhuning on in vivo Candida albicans biofilms in rats

Cited by 2 publications

References 0 publications

Normative Application of Xiyanping Injection: A Systematic Review of Adverse Case Reports

Normative Application of Xiyanping Injection: A Systematic Review of Adverse Case Reports

Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity

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