Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity

Wang, Mengjie; Tao, Ling; Hong, Xu

doi:10.1186/s13020-016-0074-0

Cited by 23 publications

(23 citation statements)

References 153 publications

(153 reference statements)

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“…Indeed, an increase in the phosphorylation of p38 kinase was observed in EV71‐infected RD cells (Figure ), whereas the levels of phosphorylated p38 (P‐p38) kinase declined significantly in cells after treatment with Cur‐CQDs‐180. Our results suggest that Cur‐CQDs‐180 can inhibit ROS formation and the resultant p38 kinase activation induced by EV71, which agrees with the reports that highly antioxidative polyphenols, flavonoids, and terpenoids mediated to alleviate enterovirus infections . A further report indicated that natural compounds with high ROS scavenging activity could inhibit EV71‐induced cyclooxygenase‐2 (COX‐2) expression and regulate prostaglandin E‐2 (PGE 2 ) release by activating multiple inflammatory signaling pathways .…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, the most important point is that none of them has been demonstrated to be sufficiently effective at the clinical level. In addition to synthetic compound design, natural phytochemical extracts such as flavones, terpenes, polyphenols, steroids, and curcuminoids have shown high potential as anti‐EV71 agents . These natural compounds exhibit various effects, such as targeting viral capsid proteins and proteases and suppressing oxidative stress to inhibit EV71.…”

Section: Resultsmentioning

confidence: 99%

“…Further, EV71 vaccines are not currently available in most countries . To date, studies on herbal‐derived medicines and isolated compounds (e.g., flavone, terpene, polyphenol, and steroid‐related compounds) that target various stages of the virus cycle have shown some promise of inhibiting EV71 . Curcumin has become an attractively therapeutic candidate to treat viral infectious disease …”

Section: Introductionmentioning

confidence: 99%

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High Amplification of the Antiviral Activity of Curcumin through Transformation into Carbon Quantum Dots

Lin

Chang

Chu

et al. 2019

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119

116

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It is demonstrated that carbon quantum dots derived from curcumin (Cur‐CQDs) through one‐step dry heating are effective antiviral agents against enterovirus 71 (EV71). The surface properties of Cur‐CQDs, as well as their antiviral activity, are highly dependent on the heating temperature during synthesis. The one‐step heating of curcumin at 180 °C preserves many of the moieties of polymeric curcumin on the surfaces of the as‐synthesized Cur‐CQDs, resulting in superior antiviral characteristics. It is proposed that curcumin undergoes a series of structural changes through dehydration, polymerization, and carbonization to form core–shell CQDs whose surfaces remain a pyrolytic curcumin‐like polymer, boosting the antiviral activity. The results reveal that curcumin possesses insignificant inhibitory activity against EV71 infection in RD cells [half‐maximal effective concentration (EC50) >200 µg mL−1] but exhibits high cytotoxicity toward RD cells (half‐maximal cytotoxic concentration (CC50) <13 µg mL−1). The EC50 (0.2 µg mL−1) and CC50 (452.2 µg mL−1) of Cur‐CQDs are >1000‐fold lower and >34‐fold higher, respectively, than those of curcumin, demonstrating their far superior antiviral capabilities and high biocompatibility. In vivo, intraperitoneal administration of Cur‐CQDs significantly decreases mortality and provides protection against virus‐induced hind‐limb paralysis in new‐born mice challenged with a lethal dose of EV71.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High Amplification of the Antiviral Activity of Curcumin through Transformation into Carbon Quantum Dots

Lin

Chang

Chu

et al. 2019

Small

119

116

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“…Similarly, many extracts and compounds obtained from medicinal plant with antiviral activity have been reported (Kitazato et al, 2007;Rebensburg et al, 2016;Wang et al, 2016). Moreover, in general and in comparison, to the synthetic drugs, natural products are less toxic and inexpensive (Babar et al, 2013).…”

Section: Introductionmentioning

confidence: 96%

Anti-Viral Effects of Medicinal Plants in the Management of Dengue: A Systematic Review

Frederico¹,

Cardoso²,

Moreira-Marconi³

et al. 2017

Afr J Tradit Complement Altern Med

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Background:Dengue is considered as an important arboviral disease. Safe, low-cost, and effective drugs that possess inhibitory activity against dengue virus (DENV) are mostly needed to try to combat the dengue infection worldwide. Medicinal plants have been considered as an important alternative to manage several diseases, such as dengue. As authors have demonstrated the antiviral effect of medicinal plants against DENV, the aim of this study was to review systematically the published research concerning the use of medicinal plants in the management of dengue using the PubMed database.Materials and Methods:Search and selection of publications were made using the PubMed database following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA statement).Results:Six publications met the inclusion criteria and were included in the final selection after thorough analysis.Conclusion:It is suggested that medicinal plants’ products could be used as potential anti-DENV agents.

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“…In spite of these efforts and anti-TB drug developments, the rapid emergence of TB and multidrug-resistant TB (MDR-TB) or extensively drug-resistant TB (XDR-TB) has consistently worsened the public health problem worldwide. Until recently, medicinal plants used in traditional oriental medicine were utilized as traditional medical resources for treating chronic diseases and/or symptoms which are induced by viral and parasitic infections, hepatitis, and cancer, in both “in vivo” and “in vitro” [8,9,10,11]. Furthermore, recently it was reported that various extracts and/or natural products derived from medicinal plants or traditional oriental medicines significantly indicated anti-Mtb activities/effects against Mtb [12,13,14,15,16].…”

Section: Introductionmentioning

confidence: 99%

Novel Pharmacological Activity of Artesunate and Artemisinin: Their Potential as Anti-Tubercular Agents

Choi

2017

JCM

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Tuberculosis is a major infectious disease that globally causes the highest human mortality. From this aspect, this study was carried out to evaluate novel pharmacological activities/effects of artesunate and artemisinin causing anti-tubercular activity/effects against Mycobacterium tuberculosis (Mtb). The anti-Mtb activities/effects of artesunate and artemisinin were evaluated using different anti-Mtb indicator assays, such as the resazurin microtiter assay, the Mycobacteria Growth Indicator Tube (MGIT) 960 system assay, and the Ogawa slant medium assay, as well as in vivo tests. Artesunate showed selective anti-Mtb effects by strongly inhibiting the growth of Mtb compared to artemisinin, and consistently induced anti-Mtb activity/effects by effectively inhibiting Mtb in the MGIT 960 system and in Ogawa slant medium for 21 days with a single dose; its minimum inhibitory concentration was 300 µg/mL in in vitro testing. Furthermore, artesunate demonstrated an anti-tubercular effect/action with a daily dose of 3.5 mg/kg in an in vivo test for four weeks, which did not indicate or induce toxicity and side effects. These results demonstrate that artesunate effectively inhibits the growth and/or proliferation of Mtb through novel pharmacological activities/actions, as well as induces anti-Mtb activity. This study shows its potential as a potent candidate agent for developing new anti-tuberculosis drugs of an effective/safe next generation, and suggests novel insights into its effective use by repurposing existing drugs through new pharmacological activity/effects as one of the substantive alternatives for inhibiting tuberculosis.

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Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity

Cited by 23 publications

References 153 publications

High Amplification of the Antiviral Activity of Curcumin through Transformation into Carbon Quantum Dots

High Amplification of the Antiviral Activity of Curcumin through Transformation into Carbon Quantum Dots

Anti-Viral Effects of Medicinal Plants in the Management of Dengue: A Systematic Review

Novel Pharmacological Activity of Artesunate and Artemisinin: Their Potential as Anti-Tubercular Agents

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