Effect of anaerobic resistance training on gastric emptying of solids, nutritional parameters and food behavior in the rats treated with dexamethasone

Telles, Pedro Victor Nogueira; Severo, Juliana Soares; Oliveira, Lúcia Castro Santos de; Sousa, Jessica Fernanda Reis e; Cavalcante, Ana Karolina Martins; Silva, Alda Cássia Alves da; Santos, Armênio Aguiar dos; Tolentino, Moisés

doi:10.1016/j.physbeh.2021.113674

Cited by 3 publications

(3 citation statements)

References 46 publications

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“…The finding that the three-drug regimen administration reduced BW is consistent with the findings of a previous study wherein rats were treated with dexamethasone. 23) This result suggests that anamorelin did not exhibit a discernible drug effect, while dexamethasone appeared to influence weight loss. Cisplatin administration causes behavioral inhibition in rats at night.…”

Section: Discussionmentioning

confidence: 97%

Drug Repositioning Study on the Antiemetic Efficacy of Anamorelin for Cisplatin-Induced Nausea and Vomiting in Rats

Nishino,

Kawazoe,

Sekiguchi

et al. 2024

BPB Reports

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Platinum-and anthracycline-based chemotherapy regimens cause nausea and vomiting in clinical practice, resulting in the deterioration of patients' QoL, discontinuation of chemotherapy, and reduced therapeutic outcomes. Using pica behavior as an indicator, we aimed to clarify whether anamorelin, an orally active ghrelin receptor agonist, exerts antiemetic effects against cisplatin-induced nausea and vomiting in rats. Materials and Methods: Sprague-Dawley rats were treated with cisplatin (5 mg/kg, i.p.), three-drug or fourdrug antiemetics (granisetron [0.3 mg/kg, p.o.], dexamethasone [1.5 mg/kg, p.o.], fosaprepitant [12.5 mg/kg, i.p.], with or without anamorelin [30 mg/kg, p.o.]). Data on kaolin intake, normal food intake, and spontaneous motor activity (SMA) were recorded 1 d before and 5 d after cisplatin administration. Body weight (BW) was measured daily, and the percentage change in BW from baseline was calculated. Results: At the primary endpoint, kaolin intake was significantly higher in the cisplatin-only group than in the pretreatment and vehicle groups (p < 0.05). Additionally, kaolin food intake was not significantly low in cisplatin-treated mice treated with three-drug antiemetics with or without anamorelin. At the secondary endpoints, normal food intake, SMA, and percentage change in BW were significantly lower in the cisplatin-only group than in the vehicle group. Conclusion: Our findings suggest that the prophylactic administration of standard three-drug antiemetics, besides anamorelin, may not improve cisplatin-induced nausea and vomiting. Further studies using methods suitable for evaluating anamorelin levels are required.

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Section: Discussionmentioning

confidence: 97%

Drug Repositioning Study on the Antiemetic Efficacy of Anamorelin for Cisplatin-Induced Nausea and Vomiting in Rats

Nishino,

Kawazoe,

Sekiguchi

et al. 2024

BPB Reports

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“…GSH and NO are major regulators of GE according to Pérez et al ( 35 ). ROS/RNS may also account for the regulation of GE via a complex mechanism that involves i) the production and release of gasotransmitters, such as NO (produced by NOS), and ii) the participation of antioxidant factors, such as GSH and related enzymes, which control the generation of reactive species and provide mucosal protection against gastric acid secretion ( 13 ). In this regard, our findings showed that the amount of NOx positively correlated with the GE rate, both in control and SHR animals.…”

Section: Discussionmentioning

confidence: 99%

“…Gastric emptying (GE) of solids was analyzed according to the method described by Telles et al ( 13 ). One week before the experimental protocols and the pharmacological intervention, Wistar or SHR rats were placed in individual cages with free access to water and feed in Petri dishes, for acclimation to the feeding site.…”

Section: Methodsmentioning

confidence: 99%

P2X7 receptor antagonist improves gastrointestinal disorders in spontaneously hypertensive rats

Oliveira

Silva

et al. 2023

Braz J Med Biol Res

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The purinergic system participates in the control of blood pressure. Hypertension promotes the occurrence of gastrointestinal disorders such as intestinal inflammation and gastric emptying delay. This study aimed i) to investigate the participation of the P2X7 receptor blocker Brilliant Blue G (BBG) on gastric emptying of solids and changes in oxidative stress in the gastric fundus, duodenum, and colon of spontaneously hypertensive rats (SHR) and ii) to study the putative relationship of this effect with the renin-angiotensin system. Rats were divided into five groups: Control, SHR, SHR+BBG, SHR+BBG+ATP, and SHR+BBG+ANG II. In the gastrointestinal tract, we assessed gastric emptying (GE) and oxidative stress markers (NOx, MPO, GSH, SOD). We observed a decrease in the GE rate (P<0.05) in SHR vs control rats (21.8±2.0% vs 42.8±3.5%). The decrease in GE was returned (P<0.05) to control levels by BBG in SHR rats (21.8±2.0% vs 41.6±3.2%). Co-administration of ATP or ANG II together with BBG bypassed the effect of the P2X7 antagonist on GE in SHR (P<0.05) (21.9±5.0% vs 25.6±3.0% vs 41.6±3.2%). The MPO activity increased (P<0.05) in the gastric fundus of SHR compared to control rats (6.12±2.26 vs 0.077±0.02 UMPO/mg tissue); this effect was prevented (P<0.05) by BBG (0.55±0.15 vs 6.12±2.26 UMPO/mg tissue). Data demonstrated that blockage of P2X7 receptors with BBG can improve the GE delay and oxidative stress biomarkers in SHR animals. This preventive effect of BBG on GE delay was abrogated by ANG II and ATP, thus prompting crosstalk between renin-angiotensin and the purinergic signaling systems underlying this phenomenon.

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Physical exercise alleviates oxidative stress in brown adipose tissue and causes changes in body composition and nutritional behavior in rats with polycystic ovary syndrome

et al. 2023

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Effect of anaerobic resistance training on gastric emptying of solids, nutritional parameters and food behavior in the rats treated with dexamethasone

Cited by 3 publications

References 46 publications

Drug Repositioning Study on the Antiemetic Efficacy of Anamorelin for Cisplatin-Induced Nausea and Vomiting in Rats

Drug Repositioning Study on the Antiemetic Efficacy of Anamorelin for Cisplatin-Induced Nausea and Vomiting in Rats

P2X7 receptor antagonist improves gastrointestinal disorders in spontaneously hypertensive rats

Physical exercise alleviates oxidative stress in brown adipose tissue and causes changes in body composition and nutritional behavior in rats with polycystic ovary syndrome

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