Effect of an orally administered antacid agent containing aluminum hydroxide and magnesium hydroxide on abomasal luminal pH in clinically normal milk-fed calves

Aljawadi, Ahmed; Constable, Peter D.; Misk, N. A.

doi:10.2460/javma.2002.220.74

Cited by 23 publications

(17 citation statements)

References 24 publications

(18 reference statements)

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“…This value was similar to those obtained in studies 16,17,58 involving dairy calves fed the same or similar milk replacer. However, given that enteric pathogens are killed at a pH < 3.0 to 3.5 and multiply at a pH > 5.0 to 5.5, it would not be beneficial for a calf to maintain gastric pH > 5.5 for a substantial portion of the 24-hour period.…”

Section: Discussionsupporting

confidence: 88%

Effect of orally administered electrolyte solution formulation on abomasal luminal pH and emptying rate in dairy calves

Smith¹,

Aljawadi²,

Constable³

2012

javma

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Section: Discussionsupporting

confidence: 88%

Effect of orally administered electrolyte solution formulation on abomasal luminal pH and emptying rate in dairy calves

Smith¹,

Aljawadi²,

Constable³

2012

javma

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“…64 The mean preprandial pH is constant between 1.4 and 1.7 after day 5 of life. 65,66 The relatively high pH during the first day of life ensures ingested colostral immunoglobulins are minimally degraded before arriving in the small intestine, which is the site of immunoglobulin absorption. Unfortunately, the high abomasal pH also allows ingested E coli and Salmonella spp.…”

Section: Increasing Nonspecific Resistancementioning

confidence: 99%

Treatment of Calf Diarrhea: Antimicrobial and Ancillary Treatments

Constable

2009

Veterinary Clinics of North America: Food Animal Practice

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Adjunct treatment of diarrhea should be routinely undertaken in all calves with systemic signs of illness, manifest as fever, inappetance, or lethargy. Ancillary treatments with documented efficacy in undifferentiated calf diarrhea include parenteral administration of antimicrobials with a predominantly gram negative spectrum of activity, parenteral administration of non-steroidal anti-inflammatory agents such as meloxicam and flunixin meglumine, and continued feeding of cow's milk. Halofuginone and azithromycin have efficacy in calves with diarrhea due to Cryptosporidium parvum, and their administration should be considered in calves documented or suspected to have cryptosporidiosis.

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“…Treatment of gastric ulceration in other species includes increasing gastric pH by use of PO alkalinizing agents or suppression of gastric acid production. The use of PO alkalinizing agents such as magnesium hydroxide and PO gastric acid suppressants including histamine type‐2 receptor antagonists (H 2 RA) and proton pump inhibitors (PPI) has been studied in pre‐ruminant calves . These agents have variable efficacy in increasing abomasal pH in pre‐ruminants.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and efficacy of intravenous famotidine in adult cattle

Balcomb

Heller

Chigerwe

et al. 2018

Veterinary Internal Medicne

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BackgroundAbomasal ulceration is recognized in neonatal and adult cattle, but research regarding treatment is limited. Histamine‐2 receptor antagonists (H2RA), such as famotidine, are used clinically with little evidence‐based research about efficacy in adult cattle.Hypothesis and ObjectivesIntravenous famotidine administered at 0.4 mg/kg will increase the pH of abomasal outflow digesta compared to saline control in adult cattle. The objectives were to assess the effect of famotidine, administered as a single dose and as multiple doses, on abomasal outflow fluid pH in adult cattle. A third objective was to describe the pharmacokinetic parameters of IV famotidine in cattle.AnimalsFour clinically healthy adult Angus‐cross steers previously fitted with duodenal cannulae placed orad to the biliary and pancreatic ducts.MethodsRandomized, 2‐way cross‐over clinical trial. Steers received IV famotidine (0.4 mg/kg) as a single and 3‐dose regimen (every 8 hours) versus saline control. Blood for analysis of serum famotidine concentration was collected intermittently for 12 hours, and abomasal outflow fluid pH was measured at intervals for a 24‐hour period. After a 34‐hour washout period, the opposite treatments were administered and the sampling repeated.ResultsAbomasal outflow fluid pH was higher in steers treated with famotidine for up to 4 hours after a single dose but the effect decreased with subsequent doses. The median (range) elimination half‐life was 3.33 (3.21‐3.54) hours.Conclusions and Clinical ImportanceFamotidine may be useful for treatment or prevention of abomasal ulceration in adult cattle, but the duration of effect may decrease with time.

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Effect of an orally administered antacid agent containing aluminum hydroxide and magnesium hydroxide on abomasal luminal pH in clinically normal milk-fed calves

Cited by 23 publications

References 24 publications

Effect of orally administered electrolyte solution formulation on abomasal luminal pH and emptying rate in dairy calves

Effect of orally administered electrolyte solution formulation on abomasal luminal pH and emptying rate in dairy calves

Treatment of Calf Diarrhea: Antimicrobial and Ancillary Treatments

Pharmacokinetics and efficacy of intravenous famotidine in adult cattle

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