Effect of an intravitreal cyclosporine implant on experimental uveitis in horses

Gilger, Brian C.; Malok, Emily; Stewart, Tammy; Horohov, David W.; Ashton, Paul; Smith, Thomas D.; Jaffe, Glenn J.; Allen, Julie K.

doi:10.1016/s0165-2427(00)00219-1

Cited by 64 publications

(50 citation statements)

References 12 publications

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“…should be evaluated. It is possible, that these horses benefit from the suprachoroidal implantation of a CSA-releasing device (Gilger et al 2000a, Gilger et al 2000b, Gilger et al 2001, Gilger and Spiess 2006 …”

Section: Discussionmentioning

confidence: 99%

The outcome of pars plana vitrectomy in horses with equine recurrent uveitis with regard to the presence or absence of intravitreal antibodies against various serovars of Leptospira interrogans

Tömördy¹,

Hässig²,

Spiess³

2010

PHK

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Section: Discussionmentioning

confidence: 99%

The outcome of pars plana vitrectomy in horses with equine recurrent uveitis with regard to the presence or absence of intravitreal antibodies against various serovars of Leptospira interrogans

Tömördy¹,

Hässig²,

Spiess³

2010

PHK

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“…Die Operation, Vor-und Nachsorge der ERU-Patienten erfolgte, wie bereits beschrieben (Frühauf et al 1998, von Borstel 2005,Tóth et al 2006, 2010 Auch die suprachoroidale Applikation eines Ciclosporin AImplantats (Gilger et al 2000a, Gilger et al 2000b, Gilger et al 2001, Gilger and Spiess 2006 kann aus Sicht der Autoren bei ERU nicht an die Erfolgsrate der PPV anknüpfen, so dass aufgrund mangelnder therapeutischer Alternativen, einer nach wie vor ungeklärten Ätiopa-thogenese der ERU, regionaler Unterschiede in der Leptospirenprävalenz und der Varianz der MAT-Ergebnisse (Baake et al 2016) …”

unclassified

Long-term results of pars plana vitrectomy in relationship to leptospiral antibody detection in vitreous humor in 118 horses with equine recurrent uveitis (ERU)

Keiter¹,

Töth²,

Dikker³

et al. 2017

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Long-term results of pars plana vitrectomy in relationship to leptospiral antibody detection in vitreous humor in 118 horses with equine recurrent uveitis (ERU)In the ongoing discussion regarding aetiopathogenesis and therapeutic approach of equine recurrent uveitis (ERU) it was the aim of the present study to elucidate the relationship of leptospiral antibody detection in vitreous humor and success of pars plana vitrectomy (PPV) in horses with ERU. In a retrospective study of 118 ERU patients of different age, gender and breed undiluted vitreous humor, aseptically taken at the beginning of PPV, was examined by culture. Furthermore vitreous humor and serum were tested for specific antibodies against different serovars of Leptospira interrogans by microscopic agglutination test (MAT). Horses were treated via single port pars plana vitrectomy. The presence or absence of inflammation of the inner eye 8 to 54 months after PPV was evaluated by repeated ocular examinations, as well as by interrogation of referring veterinarians and horse owners. The absence of recurrent inflammation in terms of symptoms of classic uveitis after surgery was considered a success. A total of 55 of 118 horses (46.6 %) had serum antibodies against different serovars of Leptospira (L.) interrogans (≥ 1 : 100). Culture of vitreous humor was positive in 16/118 (13.6 %) patients with ERU. In 49 of 118 horses (41.5 %) and 52 of 134 eyes (38.8 %) leptospiral antibodies were detected in vitreous humor via MAT. L. interrogans serovar Grippotyphosa (48) and L. interrogans serovar Pomona (12) were identified most frequently. A total of 90/118 (76.3 %) horses and 104/134 eyes (77.6 %) remained relapse-free over a period of 8 to 54 months. Forty-one/49 horses (83.7 %) and 44/52 eyes (84.6 %), tested positive for antibodies against L. interrogans via MAT and 49/69 horses (71.0 %) and 60/82 eyes (73.2 %), in which no leptospiral antibodies were detected in vitreous humor, showed no further episodes of ERU (Fishers exact test: P ≥ 0.05). These findings confirm the therapeutic approach to perform a vitrectomy according to the clinical ERU diagnosis irrespective of the leptospiral antibody result.Keywords: horse, equine recurrent uveitis, vitrectomy, leptospira; ophthalmology Zitation: Dorrego Keiter E., Tóth J., Dikker L., Sielhorst J., Schusser G. F. (2017) Long-term results of pars plana vitrectomy in relationship to leptospiral antibody detection in vitreous humor in 118 horses with equine recurrent uveitis

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“…A natureza progressiva da URE é responsável pelo subsequente desenvolvimento de catarata, adesões intraoculares, phthisis bulbi e cegueira, e em associação com as dificuldades encontradas no tratamento são as maiores causas de eutanásia em cavalos, realizadas por segurança ou razões éticas e humanitárias (Deeg et al, 2001;Gilger et al, 1999) . Acredita-se que a URE tenha uma importante parcela imunomediada na sua patogênese (Deeg et al, 2001), e tem sido estudada com intensidade pela semelhança com as uveítes recorrentes em seres humanos, como por exemplo a uveíte intermediária ou a doença de Behçet´s (Gilger et al, 2000). O tratamento da uveíte é realizado de forma tópica, periocular, intraocular e sistêmica.…”

Section: Desenvolvimentounclassified

“…210, Art. 1399, 2012 em severos efeitos adversos (Fialho e Cunha Júnior, 2007 Devido a todas as dificuldades encontradas, algumas pesquisas têm sido realizadas no sentido de desenvolver sistemas de administração intraoculares que permitam liberar concentrações terapêuticas dos fármacos por um período prolongado e adequado (Rubsamen et al, 1994;Hashizoe et al, 1994;Chang e Wong, 1999;Gilger et al, 2000;Avitabile et al, 2001;Okabe et al, 2003;Sakurai et al, 2003;Saliba et al, 2008;Choonara et al, 2011;Haghjou et al, 2011). Tais sistemas podem proporcionar inúmeras vantagens, como aumentar a biodisponibilidade do fármaco, no sentido de obter uma liberação constante e prolongada; aumentar as concentrações locais, sem a ocorrência de efeitos adversos sistêmicos; atingir mais especificamente um tipo de tecido ou célula; reduzir a freqüência de injeções intraoculares.…”

Section: Introductionunclassified

Untitled

2012

Pubvet

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ResumoDoenças do segmento posterior do bulbo do olho são responsáveis pela maioria dos casos de cegueira irreversível no mundo inteiro e, até o momento, BIONDI, F. et al. Implantes poliméricos intraoculares de fármacos na medicina veterinária, revisão de literatura e relato de um caso. PUBVET, Londrina, V. 6, N. 23, Ed. 210, Art. 1399, 2012 apresentam sucesso terapêutico limitado devido à dificuldade de penetração dos fármacos neste local. Na medicina veterinária, as doenças oculares crônicas apresentam frequente insucesso terapêutico por conta da frequência e via de administração, além do alto custo das medicações. Visando a obtenção de níveis terapêuticos adequados de fármacos por períodos prolongados e a diminuição de efeitos colaterais indesejados, alguns sistemas de liberação poliméricos de implantação intraocular estão sendo investigados. Eles são preparados na forma de implantes a partir de polímeros que podem ser biodegradáveis ou não biodegradáveis, e pretendem revolucionar a oftalmologia humana e veterinária, aumentando o conforto do paciente e a eficácia medicamentosa no tratamento de doenças até o momento tidas como irreversíveis por conta das dificuldades terapêuticas á elas relacionadas.Palavras-chave: doenças oculares; medicação intraocular; sistemas de liberação. Polymeric implants for intraocular administration of drugs inveterinary medicine -review of the literature and report of a case AbstractDiseases of the posterior segment of the eye are responsible for most cases of irreversible blindness, and until at the present moment, have limited therapeutic success due to the difficulty of penetration of drugs in this site. In veterinary medicine, chronic eye diseases are often frustrating to treat due to the frequency and route of administration, besides the high cost of the drugs involved. In order to obtain therapeutic levels of these drugs for prolonged periods and to promote reduction of unwanted side effects, some polymeric delivery systems designed for intraocular implantation are currently being investigated. They are prepared in the form of implants from polymers that can be classified in biodegradable or nonbiodegradable, and are aimed to revolutionize medical and veterinary ophthalmology, increasing patient comfort BIONDI, F. et al. Implantes poliméricos intraoculares de fármacos na medicina veterinária, revisão de literatura e relato de um caso. PUBVET, Londrina, V. 6, N. 23, Ed. 210, Art. 1399, 2012 and effectiveness of drugs in the treatment of diseases, which are so far regarded as irreversible because of the difficulties therapies related to them.Keywords: eye diseases; intraocular medication; systems release. INTRODUÇÃOAs doenças oculares acometem as mais diversas espécies, incluindo a espécie humana, podendo causar intenso desconforto, comprometimento da acuidade visual e, por fim, cegueira. Sabe-se que as doenças do segmento posterior do olho são responsáveis pela maioria dos casos de cegueira irreversível no mundo (Fialho e Cunha Júnior, 2007). Em seres humanos, crescem os caso...

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Effect of an intravitreal cyclosporine implant on experimental uveitis in horses

Cited by 64 publications

References 12 publications

The outcome of pars plana vitrectomy in horses with equine recurrent uveitis with regard to the presence or absence of intravitreal antibodies against various serovars of Leptospira interrogans

The outcome of pars plana vitrectomy in horses with equine recurrent uveitis with regard to the presence or absence of intravitreal antibodies against various serovars of Leptospira interrogans

Long-term results of pars plana vitrectomy in relationship to leptospiral antibody detection in vitreous humor in 118 horses with equine recurrent uveitis (ERU)

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