Effect of an increased dose of colchicine on microalbuminuria in children with Familial Mediterranean Fever

Marzouk, Huda; Mostafa, Noha; Khalifa, Iman; Badawi, Nora

doi:10.1016/j.ejr.2020.02.008

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…Given the considerable number of consanguineous marriages in Egypt, it is not surprising that 82.5% of cases had a family history of FMF; a different Egyptian study found that 61% of patients had a family history of FMF (26). Of our FMF patients, 17.5% had V726A mutations, and 15% had M694I mutations.…”

Section: Discussionmentioning

confidence: 73%

Serum Uric Acid Level Among Children with Familial Mediterranean Fever

Marzouk,

Atef,

El-Khity

et al. 2024

Pediatric Sciences Journal

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Background: Familial Mediterranean fever (FMF) is the most frequent form of inherited periodic fever syndromes. It is caused by a mutation in the MEFV gene and is transmitted by autosomal recessive mode. It is marked by recurring fever episodes with a range of symptoms due to inflammation in the pleura, synovium, and peritoneum. In FMF patients, subclinical inflammation frequently persists throughout the attack-free periods. Uric acid is a product of purine nucleotides catabolism. It is elevated in tissue damage. Aim of the work:To assess uric acid levels and glomerular filtration rate (GFR) in children with FMF during the attack-free period. Subjects and Methods: This cross-sectional study assessed uric acid levels and GFR in 40 children with FMF during the attack-free period. They were enrolled from the

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Section: Discussionmentioning

confidence: 73%

Serum Uric Acid Level Among Children with Familial Mediterranean Fever

Marzouk,

Atef,

El-Khity

et al. 2024

Pediatric Sciences Journal

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“…Although mutations of MEFV gene, particularly homozygous M694V mutation, are associated with higher risk of amyloidosis, 23 in a case series, the different mutations were not correlated with urinary MA and urinary MA/creatinine ratio. 42 2) Serum amyloid A levels are significantly correlated to the risk of mortality from amyloidosis. 43,44 It is considered a reliable indicator of subclinical inflammation and treatment adherence.…”

Section: Non-amyloid Kidney Disease (Nakd)mentioning

confidence: 99%

“…52 Treatment of renal complications of FMF Amyloidosis secondary to FMF, if diagnosed early, could follow regressive or, at least, stationary course when properly treated with colchicine. 42,53 Adjusted doses of colchicine should be considered in patients with impaired creatinine clearance. Close arterial blood pressure monitoring is mandatory in all patients with proteinuria.…”

Section: Non-amyloid Kidney Disease (Nakd)mentioning

confidence: 99%

The spectrum of urological disease in familial Mediterranean fever: amyloidosis and beyond

Hassan

Shousha

El-Sayed

2022

Egypt J Pediatr Allergy Immunol

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“…Anti-interleukin-1 drugs emerged as promising treatment options in patients who fail to respond or tolerate colchicines. 12,13 This work aimed to study the role of S100A12 and resolvin D1 in the diagnosis and detection of subclinical inflammation in children with FMF during the quiescent stage of the disease.…”

Section: Introductionmentioning

confidence: 99%

Clinical Implications of S100A12 and Resolvin D1 Serum Levels, and Related Genes in Children with Familial Mediterranean Fever

Abdallah

Ibrahim

Thomas

et al. 2021

Journal of Child Science

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The aim of this article was to study the role of S100A12 and resolvin D1-related genes and serum levels in the diagnosis and detection of subclinical inflammation in children with familial Mediterranean fever (FMF) during the quiescent stage of the disease. Seventy-eight children with FMF during the silent state and 60 healthy control were studied. Serum S100A12 and resolvin D1 were quantitatively measured using enzyme-linked immunosorbent assay. In addition, the levels of C-reactive protein, erythrocyte sedimentation rate, and hemoglobin were determined. The clinical severity was evaluated. The link between the Mediterranean fever (MEFV) gene and the genes related to the two studied biomarkers was also assessed. Correlation between S100A12 and resolvin D1 and the clinical severity was assessed. The mean serum levels of S100A12 and resolvin D1 were 847.4 and 793.3, respectively, which were highly significantly increased (p = 0.001) compared with the controls (324.3 and 235.1, respectively). The receiver operating characteristic curve test showed that S100A12 had a sensitivity of 97.4% and specificity of 80% with cutoff value of 529.5, while resolvin D1 showed a sensitivity of 100% and specificity of 50% with cutoff value of 231.2. A correlation was detected between the clinical severity and S100A12 and resolvin D1. This study delineated that S100A12 and resolvin D1 are sensitive biomarkers to detect the degree of inflammation in children with FMF during the silent period. Consequently, we recommend adjusting the colchicine dose to ameliorate the disease's symptoms and to improve the quality of life in these patients.

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Effect of an increased dose of colchicine on microalbuminuria in children with Familial Mediterranean Fever

Cited by 7 publications

References 25 publications

Serum Uric Acid Level Among Children with Familial Mediterranean Fever

Serum Uric Acid Level Among Children with Familial Mediterranean Fever

The spectrum of urological disease in familial Mediterranean fever: amyloidosis and beyond

Clinical Implications of S100A12 and Resolvin D1 Serum Levels, and Related Genes in Children with Familial Mediterranean Fever

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