Serum Uric Acid Level Among Children with Familial Mediterranean Fever

Abstract

Background: Familial Mediterranean fever (FMF) is the most frequent form of inherited periodic fever syndromes. It is caused by a mutation in the MEFV gene and is transmitted by autosomal recessive mode. It is marked by recurring fever episodes with a range of symptoms due to inflammation in the pleura, synovium, and peritoneum. In FMF patients, subclinical inflammation frequently persists throughout the attack-free periods. Uric acid is a product of purine nucleotides catabolism. It is elevated in tissue damage. Aim of the work:To assess uric acid levels and glomerular filtration rate (GFR) in children with FMF during the attack-free period. Subjects and Methods: This cross-sectional study assessed uric acid levels and GFR in 40 children with FMF during the attack-free period. They were enrolled from the