Effect of an ibuprofen-releasing foam dressing on wound pain: a real-life RCT

R, Palao I. Domenech; Romanelli, Marco; Tsiftsis, D; Slonková,; Jortikka, A; Johannesen, Niels; Ram, Alpana; Persson, L; Altındaş, Muzaffer; Orsted, Heather L.; Schäfer, Elmar

doi:10.12968/jowc.2008.17.8.30797

Cited by 14 publications

(14 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Optimizing the analgesic treatment of injured patients is thus of major importance. In order to avoid several side effects that analgesic drugs have, the local application could be a good alternative (Palao i Domenech et al, 2008; Marques et al, 2014). However, there are difficulties in quantitively controlling and prolonging the release of analgesic drug molecules such as lidocaine (LID) and diclofenac (DCF), when they are employed without any supporting matrices.…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide Thin Solid Films for Analgesic Drug Delivery and Growth of Human Skin Cells

et al. 2019

View full text Add to dashboard Cite

Chronic wounds not only lower the quality of patient's life significantly, but also present a huge financial burden for the healthcare systems around the world. Treatment of larger wounds often requires the use of more complex materials, which can ensure a successful renewal or replacement of damaged or destroyed tissues. Despite a range of advanced wound dressings that can facilitate wound healing, there are still no clinically used dressings for effective local pain management. Herein, alginate (ALG) and carboxymethyl cellulose (CMC), two of the most commonly used materials in the field of chronic wound care, and combination of ALG-CMC were used to create a model wound dressing system in the form of multi-layered thin solid films using the spin-assisted layer-by-layer (LBL) coating technique. The latter multi-layer system was used to incorporate and study the release kinetics of analgesic drugs such as diclofenac and lidocaine at physiological conditions. The wettability, morphology, physicochemical and surface properties of the coated films were evaluated using different surface sensitive analytical tools. The influence of in situ incorporated drug molecules on the surface properties (e.g., roughness) and on the proliferation of human skin cells (keratinocytes and skin fibroblasts) was further evaluated. The results obtained from this preliminary study should be considered as the basis for the development “real” wound dressing materials and for 3D bio-printing applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Polysaccharide Thin Solid Films for Analgesic Drug Delivery and Growth of Human Skin Cells

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Domenech et al 8 reported significant pain relief scores in favour of the intervention group (P , 0.0001) with almost 80% of patients experiencing relief within the first 24 hours compared with 59% in the local best practice group. Pain intensity decreased for both groups over time but with a larger reduction exhibited in the intervention group (P , 0.0001).…”

Section: Ibuprofen Foam Vs Local Best Practicementioning

confidence: 98%

“…3.5.3. Reported changes in emotional functionality or impact on mental health (eg, anxiety, depression, mood, etc) Domenech et al 8 report well-being improved significantly more in the ibuprofen treatment group 40% (n 5 187) vs the comparator group 15% (n 5 58) (P , 0.001). There were also lower levels of deterioration for the treatment group (4%) vs the comparator group (9%).…”

Section: Reported Changes In Disability or Physical Functionalitymentioning

confidence: 99%

Systematic review of topical interventions for the management of pain in chronic wounds

Ffrench,

Finn,

Velligna

et al. 2023

PR9

View full text Add to dashboard Cite

Chronic wounds adversely affect quality of life. Pain is associated with chronic wounds, and its impact can vary according to wound aetiology, condition, and patient factors. This systematic review examined the effectiveness of topical interventions in the management chronic wound–related pain guided by PRISMA recommendations of randomised controlled trials (RCTs) where pain reduction is the primary outcome. Inclusion criteria were adults (older than 18 years) with chronic venous, arterial, diabetic, or pressure ulcers where pain has been managed through topical administration of pharmacological/nonpharmacological agents. Searches were conducted in Ovid Embase, Ovid MEDLINE, EBSCOhost, CINAHL, CENTRAL, PubMed, Web of Science, and Scopus. Studies were screened for eligibility; risk of bias and data were extracted by 2 independent assessors. Searches retrieved 10,327 titles and abstracts (7760 after deduplication). Nine full texts (1323 participants) examining ibuprofen (n = 4), morphine (n = 2), BWD + PHMB [polihexanide-containing biocellulose wound dressing] (n = 1), and EMLA (n = 2) were included. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Meta-analysis was not possible, but initial exploration suggests improved outcomes (reduced pain) for ibuprofen when compared with controls. Two studies involving morphine showed conflicting findings. Included studies often had small samples, and considering confounding factors (eg, comorbidities), the results should be interpreted with caution. Review of included studies suggests that topical interventions may provide pain relief in individuals with chronic wounds. Further adequately powered RCTs are recommended to assess the efficacy of topical interventions for the management of chronic wound–related pain.

show abstract

“…Other studies have highlighted the varied ways in which healthcare professionals seek to measure and minimise patients’ pain 7–12. For example, an Irish study investigated nurses’ knowledge of wound management in relation to dressing change and pain (n=100) 12.…”

Section: Introductionmentioning

confidence: 99%

“…Other studies have highlighted the varied ways in which healthcare professionals seek to measure and minimise patients’ pain. 7–12 For example, an Irish study investigated nurses’ knowledge of wound management in relation to dressing change and pain (n=100). 12 It found that the most common methods used by nurses to assess wound pain at dressing change were talking generally to the patient and monitoring facial expression respectively.…”

Section: Introductionmentioning

confidence: 99%

Strategies for reducing pain at dressing change in chronic wounds: protocol for a mapping review

Kirkcaldy,

Wilson,

Cooper

et al. 2023

BMJ Open

View full text Add to dashboard Cite

IntroductionAlthough pain experienced at dressing change has been reported as the worst aspect of living with chronic wounds, UK guidance for their management is primarily tailored to wound healing and only attends to pain as a secondary consideration. Consequently, there is little up-to-date guidance that specifically addresses how patients, carers and healthcare professionals should manage wound-related pain at dressing change. This mapping review will identify, describe and appraise the existing research evidence for strategies used to assess pain intensity and prevent or alleviate pain at dressing change in chronic wounds. In addition, it will highlight areas for future research and inform the development of up-to-date guidance for healthcare professionals.Methods and analysisWe will search MEDLINE and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily (via Ovid SP), Embase (via Ovid SP), Cochrane Central Register of Controlled Trials (via Wiley Cochrane Library), Cumulative Index of Nursing and Allied Health Literature (via EBSCO) and the Web of Science Citation Index Expanded and Social Sciences Citation Index (via Clarivate Analytics). Screening will be undertaken independently by two reviewers, with any disagreements resolved through discussion. Included studies will be subject to coding, using a tested data extraction tool, by two reviewers working independently. The methodological quality of the studies included will be reviewed using quality assessment instruments appropriate for each study design (Cochrane Risk of Bias tool (RoB 2); Risk of Bias in Non-randomised Studies of interventions tool; Critical Appraisal Skills Programme tool). Data will be described narratively and also presented visually in an interactive web-based evidence and gap map.Ethics and disseminationAs this mapping review does not collect original data, ethical approval is not applicable. Findings will be disseminated via a written report, an interactive online mapping tool and in peer-reviewed journals and conference presentations.PROSPERO registration numberCRD42021260130.

show abstract

Effect of an ibuprofen-releasing foam dressing on wound pain: a real-life RCT

Abstract: The test dressing provided an appropriate wound healing environment, relieved temporary and persistent wound pain, and decreased pain intensity. It was also associated with an improvement in quality of life.

Cited by 14 publications

References 9 publications

Polysaccharide Thin Solid Films for Analgesic Drug Delivery and Growth of Human Skin Cells

Polysaccharide Thin Solid Films for Analgesic Drug Delivery and Growth of Human Skin Cells

Systematic review of topical interventions for the management of pain in chronic wounds

Strategies for reducing pain at dressing change in chronic wounds: protocol for a mapping review

Contact Info

Product

Resources

About