Effect of an all-trans-retinoic acid conjugate with spermine on viability of human prostate cancer and endothelial cells in vitro and angiogenesis in vivo

Vourtsis, Dionissios; Lamprou, Margarita; Sadikoglou, Eldem; Giannou, A. D.; Theodorakopoulou, Olga; Sarrou, Eliana; Magoulas, George E.; Bariamis, Stavros E.; Athanassopoulos, Constantinos M.; Drainas, Dennis; Papaioannou, Dionissios; Papadimitriou, Evangelia

doi:10.1016/j.ejphar.2012.11.007

Cited by 16 publications

(11 citation statements)

References 42 publications

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“…Retinoids have also been used in the systemic and topical treatment of various disorders, ranging from acne vulgaris to several types of cancer. It has been established that inhibiting or decreasing angiogenesis is one of main mechanism of actions of these drugs .…”

Section: Discussionmentioning

confidence: 99%

High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography

Baran

Choi

et al. 2015

Lasers Surg. Med.

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Background and Objective Acne is a common skin disease that often leads to scarring. Collagen and other tissue damage from the inflammation of acne give rise to permanent skin texture and microvascular changes. In this study, we demonstrate the capabilities of optical coherence tomography based microangiography in detecting high-resolution, three-dimensional structural and microvascular features of in vivo human facial skin during acne lesion initiation and scar development. Materials and Methods A real time swept source optical coherence tomography system is used in this study to acquire volumetric images of human skin. The system operates on a central wavelength of 1310 nm with an A-line rate of 100 kHz, and with an extended imaging range (~12 mm in air). The system uses a handheld imaging probe to image acne lesion on a facial skin of a volunteer. We utilize optical microangiography (OMAG) technique to evaluate the changes in microvasculature and tissue structure. Results Thanks to the high sensitivity of OMAG, we are able to image microvasculature up to capillary level and visualize the remodeled vessels around the acne lesion. Moreover, vascular density change derived from OMAG measurement is provided as an alternative biomarker for the assessment of human skin diseases. In contrast to other techniques like histology or microscopy, our technique made it possible to image 3D tissue structure and microvasculature up to 1.5 mm depth in vivo without the need of exogenous contrast agents. Conclusion The presented results are promising to facilitate clinical trials aiming to treat acne lesion scarring, as well as other prevalent skin diseases, by detecting cutaneous blood flow and structural changes within human skin in vivo.

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Section: Discussionmentioning

confidence: 99%

High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography

Baran

Choi

et al. 2015

Lasers Surg. Med.

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“…Angiogenesis in the placental vasculature during pregnancy is necessary for increasing uteroplacental blood flow and, therefore, the supply of nutrients from maternal to fetal circulation [ 34 ]. Several previous studies reported that spermine plays an important role in angiogenesis, early mammalian embryogenesis, placental trophoblast growth, and embryonic development in the uterus [ 35 ] and [ 36 ]. In the current study, we found that spermine synthase was down regulated in the IUGR placenta, which could reduce the production of spermine and then placental vascular development.…”

Section: Discussionmentioning

confidence: 99%

Proteome Differences in Placenta and Endometrium between Normal and Intrauterine Growth Restricted Pig Fetuses

et al. 2015

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Uteroplacental tissue plays a key role in substance exchanges between maternal and fetal circulation, and, therefore, in the growth and development of fetuses. In this study, proteomics and western blotting were applied to investigate the changes of proteome in the placenta and endometrium of normal and intrauterine growth restriction (IUGR) porcine fetuses during mid to late pregnancy (D60, 90, and 110 of gestation). Our results showed that proteins participating in cell structure, energy metabolism, stress response, cell turnover, as well as transport and metabolism of nutrients were differentially expressed in placenta and endometrium between normal and IUGR fetuses. Analysis of functions of these proteins suggests reductions in ATP production and nutrients transport, increases in oxidative stress and apoptosis, and impairment of cell metabolism in IUGR fetuses. Collectively, our findings aid in understanding of the mechanisms responsible for uteroplacental dysfunction in IUGR fetus, and are expected to provide new strategies to reduce fetal growth restriction in pigs and other mammals.

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“…However, whether T cell responses could be recovered by the abrogation of MDSCs has not been demonstrated. ATRA has been implicated in reverting mMDSC differentiation and in the induction of gMDSC apoptosis (25,(38)(39)(40)(41) and has been recognized as an MDSC-targeted drug (42,43). In this study, we employed ATRA to target HBsAg-induced mMDSCs.…”

Section: Discussionmentioning

confidence: 99%

Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection

Fang¹,

Jin

et al. 2015

The Journal of Immunology

103

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Chronic hepatitis B virus (HBV) infection is characterized by T cell tolerance to virus. Although inhibition of T cell responses by myeloid-derived suppressor cells (MDSCs) has been observed in patients with chronic hepatitis B (CHB), the mechanism for expansion of MDSCs remains ambiguous. In this study, a significant increased frequency of monocytic MDSCs (mMDSCs) was shown positively correlated to level of HBsAg in the patients with CHB. We further found hepatitis B surface Ag (HBsAg) efficiently promoted differentiation of mMDSCs in vitro, and monocytes in PBMCs performed as the progenitors. This required the activation of ERK/IL-6/STAT3 signaling feedback. Importantly, the mMDSCs polarized by HBsAg in vitro acquired the ability to suppress T cell activation. Additionally, treatment of all-trans retinoic acid, an MDSC-targeted drug, restored the proliferation and IFN-γ production by HBV-specific CD4+ and CD8+ T cells in PBMCs from patients with CHB and prevented increase of viral load in mouse model. In summary, HBsAg maintains HBV persistence and suppresses T cell responses by promoting differentiation of monocytes into mMDSCs. A therapy aimed at the abrogation of MDSCs may help to disrupt immune suppression in patients with CHB.

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Effect of an all-trans-retinoic acid conjugate with spermine on viability of human prostate cancer and endothelial cells in vitro and angiogenesis in vivo

Cited by 16 publications

References 42 publications

High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography

High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography

Proteome Differences in Placenta and Endometrium between Normal and Intrauterine Growth Restricted Pig Fetuses

Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection

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