Effect of amorphization method on the physicochemical properties of amorphous sucrose

Controlling desolvation through polymer-assisted grinding

“…In particular, a long-wavelength oscillation in the difference curve may indicate modifications to the intermolecular packing, similar to that observed in amorphous drug-polymer dispersions 37,41 and saccharide mixtures. 42,43 As a further example, in Figure 4(c), we show a similar comparison in which 2(thp)•3(2-pyr) is fit by the pure constituent phase thp Modifications to small molecule crystallite size and size distribution on co-grinding with polymers is a well-established phenomenon and therefore not surprising in this case. 44 Differences between the POLAG samples and pure components of the thp-polymer mixtures observed by Raman and PDF (SI Sections 4.5 and 4.6) suggest that the crystallite size reduction is accompanied by structural modifications to thp.…”

“…In particular, a long-wavelength oscillation in the difference curve may indicate modifications to the intermolecular packing, similar to that observed in amorphous drug-polymer dispersions 37,41 and saccharide mixtures. 42,43 As a further example, in Fig. 4(c), we show a similar comparison in which 2(thp)•3(2-pyr) is fit by the pure constituent phase thp and 2-pyr.…”

Local Structural Effects Due to Micronization and Amorphization on an HIV Treatment Active Pharmaceutical Ingredient

“…Often, the property enhancement relies on deviation from the original API crystal structure through various routes such as domain size reduction, amorphization, or molecular dispersion within an excipient compound . Different micronization and amorphization processes can lead to substantial differences in physicochemical properties such as dissolution performance and product stability. − These properties can be greatly affected by the thermodynamic and kinetic landscapes accessed, for instance through thermal, versus mechanical, or solution-based amorphization, resulting in e.g. different morphologies, domain sizes, modifications of domain structure, interactions between different crystalline and/or amorphous phases, or leftover impurities from the processing medium or degradation .…”

Phenolic Analysis and Characterization of Palm Sugar (Arenga pinnata) Produced by The Spray dryer

“…This result was different from previous researchers. Morrow et al, 14 reported that spray dryer method obtained palm sugar with spherical particles with a generally smooth surface and the particles sticking together. This rectangular shaped was almost same with morphology of commercial jaggery at Fig.…”

“…Relatively high temperature operations (140 -220 o C) lead to crystalline sucrose. Morrow et al,14 investigated that amorphous sucrose was formed by using spray dryer at very low temperature 65 o C. The main peaks of crystalline sucrose were indicated by 2θ = 8.4 o , 11.8 o , 13.2 o , 18.8 o , 19.7 o , 31.1 o , 32.1 o . The impurities peaks were also detected in the XRD patterns of the spry dried sugar i.e., at 2θ = 9.9 o which was observed at temperature 180 o C and 200 o C. It most likely the reducing sugars such as glucose and fructose were presence in the spray dried sugar as the impurities.The form of reducing sugar due to the acidity of palm sugar is high because of the fermentation process during tapping sap and waiting for the spray dryer processing15 .…”