Effect of amniotic membrane on graft take in extremity burns

Mohammadi, Abdorreza; Johari, Hamed Ghoddusi; Eskandari, Shima

doi:10.1016/j.burns.2013.01.017

Cited by 52 publications

(38 citation statements)

References 24 publications

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“…Multiple studies have shown that HAM is accompanied by rapid re-epithelialisation and promotion of wound healing by inhibition of leukocyte protease activity and angiogenesis stimulation [39]. The promotion of epithelialisation is also due to high concentration of growth factors in stromal and epithelial amnion regions [12].…”

Section: Discussionmentioning

confidence: 98%

Maximizing the safety of glycerol preserved human amniotic membrane as a biological dressing

Zidan

Eleowa

Nasef

et al. 2015

Burns

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Section: Discussionmentioning

confidence: 98%

Maximizing the safety of glycerol preserved human amniotic membrane as a biological dressing

Zidan

Eleowa

Nasef

et al. 2015

Burns

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“…From October 2013 to January 2015, in a prospective follow-up study of our previous clinical trial,[10] 54 patients (108 limbs) with second- and third-degree burns, covering 4%–15% of total body surface area (TBSA) were included. All patients needed split-thickness skin grafts for burn-wound coverage.…”

Section: Methodsmentioning

confidence: 99%

“…However, even in situ ations where the size of a single membrane is not enough, it is possible to use two or three pieces of amniotic membrane to cover the skin graft. [10]…”

Section: Methodsmentioning

confidence: 99%

“…In our previous study, we have shown the positive effect of amniotic membrane in fixation of skin grafts resulting in a shorter duration of graft take. [10] This positive effect can potentially decrease the healing time and reduce the severity of hypertrophic scar formation when a skin graft is employed. In this study, we aimed to evaluate the possible role of amniotic membrane as an adjunct in split thickness skin graft on reducing itching and severity of hypertrophic scar formation in selected patients with symmetric burns in the extremities.…”

Section: Introductionmentioning

confidence: 99%

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Using amniotic membrane as a novel method to reduce post-burn hypertrophic scar formation: A prospective follow-up study

Mohammadi¹,

Eskandari²,

Johari³

et al. 2017

J Cutan Aesthet Surg

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Background:Several studies have shown that the application of amniotic membrane as a biological dressing in the management of burns is accompanied by rapid re-epithelialisation. In this follow-up study, we aimed to evaluate the possible role of amniotic membrane as an adjunct to split thickness skin grafting on reducing itching and severity of hypertrophic scar formation.Materials and Methods:From October 2013 to January 2015, in a prospective follow-up study, 54 patients (108 limbs) with second and third degree burns, covering 4%–15% of total body surface area (TBSA), were included in the study. All patients needed split-thickness skin grafts for burn-wound coverage. Selected patients had symmetric burns on two (upper or lower) extremities. Then, in every patient, the extremities were randomly divided into two groups: In one limb, the skin graft was traditionally fixed with skin staples (control group) and in the other limb, the skin graft was covered with an amniotic membrane (amnion group). Therefore, in every patient, the graft was covered with an amniotic membrane in one extremity and fixed with skin staples in the other extremity. Finally, after 6 months, the degree of itching and hypertrophic scar formation was compared between the two groups.Results:The study group was composed of 108 limbs in 54 patients (27 males and 27 females) with a mean age of 23.54 ± 4.9 years and burn 9.03 ± 2.69% TBSA. The patients were divided into two groups: 54 limbs in amnion group and 54 limbs in control group. In 59.25% of the cases, patient had less itching in the extremity covered with amniotic membrane. Furthermore, in 64.81% of the cases, patients had less hypertrophic scar formation in the extremity covered with amniotic membrane. These differences were statistically significant (P < 0.001).Conclusions:Amniotic membrane used as an adjunct in split thickness skin grafting is a novel modality which significantly reduces scar formation and itching that can be greatly distressing to burn patients. However, still more prospective well designed studies are needed to prove it.

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“…Many wound dressings have been introduced for their efficiency in the treatment of burns. Among them, HAM has many promising features that make it an ideal scaffold for wound healing [36][37][38][39][40]. For example, Mohammadi et al [40] grafted fresh HAM in patients with chronic infected burn wounds.…”

Section: Susceptibility To Ham Samplesmentioning

confidence: 98%

Decellularized human amniotic membrane: more is needed for an efficient dressing for protection of burns against antibiotic-resistant bacteria isolated from burn patients

Gholipourmalekabadi

Bandehpour

Mozafari

et al. 2015

Burns

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Effect of amniotic membrane on graft take in extremity burns

Cited by 52 publications

References 24 publications

Maximizing the safety of glycerol preserved human amniotic membrane as a biological dressing

Maximizing the safety of glycerol preserved human amniotic membrane as a biological dressing

Using amniotic membrane as a novel method to reduce post-burn hypertrophic scar formation: A prospective follow-up study

Decellularized human amniotic membrane: more is needed for an efficient dressing for protection of burns against antibiotic-resistant bacteria isolated from burn patients

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