Decellularized human amniotic membrane: more is needed for an efficient dressing for protection of burns against antibiotic-resistant bacteria isolated from burn patients

Gholipourmalekabadi, Mazaher; Bandehpour, Mojgan; Mozafari, Masoud; Hashemi, Ali; Ghanbarian, Hossein; Zali, Hakimeh; Salimi, Morteza; Goli, Hamid Reza; Samadikuchaksaraei, Alí

doi:10.1016/j.burns.2015.04.015

Cited by 62 publications

(54 citation statements)

References 43 publications

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“…An important percentage of Gram-negative pathogenic bacteria are resistant to β-lactam antibiotics, through MBLs production. Verona integron-encoded MBLs (VIM) (12,16) and imipenemase (IMP) (12) are the main MBLs family members.…”

Section: Contextmentioning

confidence: 99%

Laboratory Detection of Carbapenemases in Gram-Negative Bacteria

Goudarzi

Taherpour

Fallah

et al. 2016

Arch Clin Infect Dis

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The nosocomial infections, caused by multi-drug resistant bacteria, are the most important cause of mortality throughout the world. One important mechanism against beta-lactam antibiotics is the production of beta-lactamases. Enterobacteriaceae and nonfermentative bacteria, like Pseudomonas aeruginosa and Acinetobacter baumannnii may produce these enzymes. Currently, there is no vaccine to prevent the infections caused by β-lactamase-producing bacteria. Consequently, it is necessary to identify β-lactamaseproducing bacteria by phenotypic and molecular methods.

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Section: Contextmentioning

confidence: 99%

Laboratory Detection of Carbapenemases in Gram-Negative Bacteria

Goudarzi

Taherpour

Fallah

et al. 2016

Arch Clin Infect Dis

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“…The inhibition of neutrophils by the amniotic cells leads to reduction of the inflammation and slower collagen decomposition, which results in quicker wound healing [6]. The multilayer amniotic membrane consisting of epithelial cells, fibroplasts and a basement membrane [7], works as an extracellular matrix (ECM). The amniotic basement membrane is rich in hyaluronic acid, collagen type I, III, IV, V and VI, laminin, elastin, fibronectin, proteoglycans [7].…”

Section: Introductionmentioning

confidence: 99%

“…The multilayer amniotic membrane consisting of epithelial cells, fibroplasts and a basement membrane [7], works as an extracellular matrix (ECM). The amniotic basement membrane is rich in hyaluronic acid, collagen type I, III, IV, V and VI, laminin, elastin, fibronectin, proteoglycans [7]. Many of the properties described above are maintained also by the amniotic membrane after the cells are removed (decellurized membrane).…”

Section: Introductionmentioning

confidence: 99%

“…It was also proved that it facilitates healing of infected wounds [9], which may be a solution for wounds colonized by multidrug-resistant strains. Decellurized amniotic membrane is also proved to inhibit the growth of E. coli (ATCC 25922), S. aureus (ATCC 25923) and P. aeruginosa (ATCC 27853) [7]. These properties make it adequate for antibacterial applications, also as grafts soaked with antibiotics or antiseptics [10].…”

Section: Introductionmentioning

confidence: 99%

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Preparation of Amniotic Membrane and It’s Application in the Treatment of Skin Loss and Lyell's Syndrome (Toxic Epidermal Necrolysis): Current State and New Opportunities

Klama-Baryła¹,

Łabuś²,

Kitala³

et al. 2017

J Clin Exp Dermatol Res

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Amniotic membrane is a good protection against bacterial infections, reduces losses of proteins, fluids and electrolytes, decreases pain from burns and accelerates healing. Due to its richness in nutrients and low immunogenicity, it is often used as a skin substitute. Human amnion may be prepared in tissue banks, as biostatic or biovital grafts. There are various methods of amniotic graft preparations developed to make them efficient in surgical treatment and prevent the risk of transmission of infectious diseases. This paper presents the current clinical application of human amnion in the treatment of skin losses, such as burns to the face and Lyell's syndrome (toxic epidermal necrolysis). It also describes new applications of fetal membranes for other diseases. Placental grafts are often an alternative therapy in the situations when standard treatment does not yield desirable effects. Such grafts are especially beneficial in comparison to many other bioactive therapies, including low cost, easy manipulation, capability of promoting cell migration and proliferation and stimulation of stem cell activity.

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“…Nowadays, increasing rates of antibiotic resistance among carbapenem-resistant E. coli isolates is a major concern worldwide (2-5). The production of ß-lactamases, including enzymes of Ambler classes A, D, and B, with the corresponding genes often associated with mobile genetic elements such as plasmids, is the most common mechanism of resistance (6,7). Extended spectrum beta-lactamases (ESBLs), produced by bacteria, are a rapidly evolving group of β-lactamase enzymes.…”

Section: Introductionmentioning

confidence: 99%

The First Report of Extended-Spectrum β-Lactamase (ESBL) Genes in an Escherichia coli Isolate from a One-Month-Old Infant with Acute Lymphoblastic Leukemia (ALL) in Iran

Roshani

Goudarzi

Sabzehali

et al. 2017

Arch Clin Infect Dis

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Background: Bloodstream infection is one of the most life-threatening complications recognized as the frequent cause of treatment failure in children with acute lymphoblastic leukemia. Objectives:In this study, we describe the isolation of an extended-spectrum β-lactamase (ESBL)-producing Escherichia coli.Methods: Antimicrobial susceptibility tests were determined on the isolate by the Kirby-Bauer disk diffusion method. In addition, ESBL production of the isolate was examined using the Combination Disk Diffusion Test (CDDT). PCR was used to screen the presence of CTX-M-1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25, ISEcp1, IS26, and IS903 genes in this isolate. Results: We found an ESBL-producing E. coli in a 1-month-old infant with a blood cancer that carried CTX-M-1 group enzymes. Conclusions: Our finding emphasized the need for more precise screening methods to identify the causative infectious agents at early stages of infection to choose the appropriate treatment in these severely immunocompromised patients.

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Decellularized human amniotic membrane: more is needed for an efficient dressing for protection of burns against antibiotic-resistant bacteria isolated from burn patients

Cited by 62 publications

References 43 publications

Laboratory Detection of Carbapenemases in Gram-Negative Bacteria

Laboratory Detection of Carbapenemases in Gram-Negative Bacteria

Preparation of Amniotic Membrane and It’s Application in the Treatment of Skin Loss and Lyell's Syndrome (Toxic Epidermal Necrolysis): Current State and New Opportunities

The First Report of Extended-Spectrum β-Lactamase (ESBL) Genes in an Escherichia coli Isolate from a One-Month-Old Infant with Acute Lymphoblastic Leukemia (ALL) in Iran

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