Effect of Amlodipine Upon the Protective Activity of Antiepileptic Drugs Against Maximal Electroshock-Induced Seizures in Mice

Effect of Amlodipine on the Antiepileptic Action of Lamotrigine, Gabapentin, Topiramate & Carbamazepine on Pentylenetetrazole and Maximal Electroshock Induced Seizures in Rats

“…It was found that amlodipine alone (upto 0.25mg/kg) did not affect the electroconvulsive threshold in rats and this finding is partially in agreement with those documented earlier by Kaminski et al 1999. [9] Stefani et al showed amlodipine at dose of 0.5mg/kg potentiated the anticonvulsant action of carbamazepine in MES induced seizure.…”

“…It was found that amlodipine alone (upto 0.25mg/kg) did not affect the electroconvulsive threshold in rats and this finding is partially in agreement with those documented earlier by Kaminski et al 1999. [9] Stefani et al showed amlodipine at dose of 0.5mg/kg potentiated the anticonvulsant action of carbamazepine in MES induced seizure. [10] In the present study, amlodipine at all the three doses significantly enhanced the anticonvulsant action of lamotrigine, gabapentin, topiramate and carbamazepine in both seizure models in rats.…”

Evaluation of anticonvulsant activity of amlodipine in albino rats

“…8 Kaminski et al, have shown that 5 mg/kg amlodipine significantly potentiated the anticonvulsant activity of carbamazepine, phenobarbitone and sodium valproate whereas in the present study, 4 mg/kg amlodipine showed significant anticonvulsant activity in the MES test when used alone and 1 mg/kg amlodipine had showed significant potentiation when used along with phenytoin. 6 Hence, amlodipine have anticonvulsant activity in 2 and 4 mg/kg but phenytoin was more effective than amlodipine. When amlodipine was used in combination with phenytoin in subconvulsive doses, amlodipine had potentiated the anticonvulsant action of phenytoin in MES.…”

“…Amlodipine does not alter the plasma concentrations of anti-epileptic drugs that are used concurrently. 6 The present study is done to evaluate the anticonvulsant activity of amlodipine in albino rats in the experimental animal model that included MES model. In MES model, amlodipine in doses of 2 and 4 mg/kg and phenytoin 25 mg/kg produced significant decrease in duration of flexion, tonic hind limb extension and significant increase in duration of PIS in comparison to distilled water.…”

“…It does not alter the plasma concentration of concurrently used other antiepileptics. 6,7 With these advantages of Amlodipine over other DHPs, the present study was conducted to evaluate the anticonvulsant activity of amlodipine on electroconvulsion model in albino rats.…”